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The map label for this gene is obgE

Identifier: 15836075

GI number: 15836075

Start: 628842

End: 629849

Strand: Reverse

Name: obgE

Synonym: CPj0544

Alternate gene names: 15836075

Gene position: 629849-628842 (Counterclockwise)

Preceding gene: 15836076

Following gene: 15836063

Centisome position: 51.35

GC content: 45.34

Gene sequence:

>1008_bases
ATGTTTGTAGATCAAATTACCTTAGAATTGCGTGCTGGAAAGGGCGGAAACGGCGTTGTTGCTTGGAGAAAGGAAAAATA
CCTTCCTAAAGGAGGGCCTTACGGAGGCAATGGTGGCAATGGCGGCTCCGTAATCATAGAAGCCACCACAAGTGTATATT
CTTTCGAAGCTTATAGAAATATCCGCTTTCTCAAGGCTCCCGACGGTCAGTCAGGAGCTACAAATAACCGCACAGGACGC
AGTGGTAAAGATCTAATAGTTTCTGTCCCTACAGGCACCCTGCTTCGTGATGCTGAGACTGGTGAAATCCTTCATGACTT
TACCGTAGATGGAGAGCGTCTCCTAGTGAGCCAAGGAGGAAAGGGAGGAAAAGGAAATACCTTCTTTAAGACCTCAGTAA
ACCGAGCCCCTACAAAAGCCACCCCAGGAAAACCCGGAGAAATCCGTCAGGTAGAGTTAGAACTTAAGCTCATTGCTGAT
ATCGGTTTGGTAGGGTTCCCAAATGCAGGAAAGTCCACACTATTTAATACACTCGCACATACCGAAGTGAAAGTCGGAGC
CTATCCCTTCACAACTCTGGCCCCCTCTTTGGGCCTAGTCCTTTGTAAAGATCGTTTGTATCAAAAACCCTGGATTATCG
CTGACATTCCAGGAATCATTGAAGGAGCTCATCAAAACAAAGGCCTAGGACTCGATTTTCTTCGCCATATTGAGCGCACT
CTTTTACTGCTATTTGTTATCGATGTCTCCAAAAGAGAGAGAAACTCTCCCGAAGAAGACTTAGAAACGCTCATCCACGA
GCTCCACTCTCATCAGCCAGATTTTGAAAAGAAAGATATGCTGGTAGCTTTAAATAAAATTGATGATCTTCTTCCTGACG
AACAGGAAGAATGCCTCCAAAGCTTCCAAAAGCGCTTCCCTAGCTATACATTTGTATTGATTTCAGGACTTACAGGAGAA
GGCGTCGACGGATTGTACCGCTTCTTCACACAAAGACTCGCTGTATAA

Upstream 100 bases:

>100_bases
TTCCTATTTTTCGATTTTTCAGAAACATTAAAAAAGCTCGGTTTTTTGCTCAGGCATCAAATCGAGCTTTTTTTGTTTGA
AGAAGGATAAAAACGTAATC

Downstream 100 bases:

>100_bases
CCTAACCCCATCAGCAATGATATCGTAGGACCTACTGGGAAATCTAAACAGTAGGCGATGCAAATTCCAGAAAAAGAACA
TAAGATATTCAAGAGGACCG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSVIIEATTSVYSFEAYRNIRFLKAPDGQSGATNNRTGR
SGKDLIVSVPTGTLLRDAETGEILHDFTVDGERLLVSQGGKGGKGNTFFKTSVNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLAHTEVKVGAYPFTTLAPSLGLVLCKDRLYQKPWIIADIPGIIEGAHQNKGLGLDFLRHIERT
LLLLFVIDVSKRERNSPEEDLETLIHELHSHQPDFEKKDMLVALNKIDDLLPDEQEECLQSFQKRFPSYTFVLISGLTGE
GVDGLYRFFTQRLAV

Sequences:

>Translated_335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSVIIEATTSVYSFEAYRNIRFLKAPDGQSGATNNRTGR
SGKDLIVSVPTGTLLRDAETGEILHDFTVDGERLLVSQGGKGGKGNTFFKTSVNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLAHTEVKVGAYPFTTLAPSLGLVLCKDRLYQKPWIIADIPGIIEGAHQNKGLGLDFLRHIERT
LLLLFVIDVSKRERNSPEEDLETLIHELHSHQPDFEKKDMLVALNKIDDLLPDEQEECLQSFQKRFPSYTFVLISGLTGE
GVDGLYRFFTQRLAV
>Mature_335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSVIIEATTSVYSFEAYRNIRFLKAPDGQSGATNNRTGR
SGKDLIVSVPTGTLLRDAETGEILHDFTVDGERLLVSQGGKGGKGNTFFKTSVNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLAHTEVKVGAYPFTTLAPSLGLVLCKDRLYQKPWIIADIPGIIEGAHQNKGLGLDFLRHIERT
LLLLFVIDVSKRERNSPEEDLETLIHELHSHQPDFEKKDMLVALNKIDDLLPDEQEECLQSFQKRFPSYTFVLISGLTGE
GVDGLYRFFTQRLAV

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=324, Percent_Identity=41.358024691358, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI111955139, Length=357, Percent_Identity=36.9747899159664, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI111955063, Length=185, Percent_Identity=39.4594594594595, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI4758796, Length=125, Percent_Identity=40.8, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557537, Length=119, Percent_Identity=33.6134453781513, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789574, Length=325, Percent_Identity=44.6153846153846, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=32.8125, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=310, Percent_Identity=35.8064516129032, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17552324, Length=327, Percent_Identity=29.9694189602446, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI25145600, Length=171, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25145602, Length=171, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=163, Percent_Identity=42.9447852760736, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319281, Length=121, Percent_Identity=38.0165289256198, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321612, Length=126, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129375, Length=305, Percent_Identity=39.0163934426229, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24585318, Length=293, Percent_Identity=36.8600682593857, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356473, Length=120, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CHLPN (Q9Z808)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A72065
- PIR:   D86558
- RefSeq:   NP_224740.1
- RefSeq:   NP_300599.1
- RefSeq:   NP_444759.2
- RefSeq:   NP_876837.1
- HSSP:   P44681
- ProteinModelPortal:   Q9Z808
- SMR:   Q9Z808
- GeneID:   1467244
- GeneID:   895479
- GeneID:   919230
- GeneID:   963826
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0208
- KEGG:   cpn:CPn0544
- KEGG:   cpt:CpB0564
- TIGR:   CP_0208
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- BioCyc:   CPNE115713:CPN0544-MONOMER
- BioCyc:   CPNE138677:CPJ0544-MONOMER
- BioCyc:   CPNE182082:CPB0564-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36727; Mature: 36727

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00905 GTP1_OBG; PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSVIIEATTSVYSFEAYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHCC
IRFLKAPDGQSGATNNRTGRSGKDLIVSVPTGTLLRDAETGEILHDFTVDGERLLVSQGG
EEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEEECCCCEEEEECCC
KGGKGNTFFKTSVNRAPTKATPGKPGEIRQVELELKLIADIGLVGFPNAGKSTLFNTLAH
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLAPSLGLVLCKDRLYQKPWIIADIPGIIEGAHQNKGLGLDFLRHIERT
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHH
LLLLFVIDVSKRERNSPEEDLETLIHELHSHQPDFEKKDMLVALNKIDDLLPDEQEECLQ
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
SFQKRFPSYTFVLISGLTGEGVDGLYRFFTQRLAV
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSVIIEATTSVYSFEAYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHCC
IRFLKAPDGQSGATNNRTGRSGKDLIVSVPTGTLLRDAETGEILHDFTVDGERLLVSQGG
EEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCEEEEEECCCCEEEEECCC
KGGKGNTFFKTSVNRAPTKATPGKPGEIRQVELELKLIADIGLVGFPNAGKSTLFNTLAH
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLAPSLGLVLCKDRLYQKPWIIADIPGIIEGAHQNKGLGLDFLRHIERT
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHH
LLLLFVIDVSKRERNSPEEDLETLIHELHSHQPDFEKKDMLVALNKIDDLLPDEQEECLQ
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
SFQKRFPSYTFVLISGLTGEGVDGLYRFFTQRLAV
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362