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The map label for this gene is hrcA

Identifier: 15836032

GI number: 15836032

Start: 581777

End: 582973

Strand: Direct

Name: hrcA

Synonym: CPj0501

Alternate gene names: 15836032

Gene position: 581777-582973 (Clockwise)

Preceding gene: 15836031

Following gene: 15836033

Centisome position: 47.43

GC content: 40.1

Gene sequence:

>1197_bases
ATGCTCTCAGTTACGATTGTTCTAGTAGGACTCGAGATGGCTAGATCCAAAGTCTCAAAGCGAGATTCAAAAATCCTTGA
TATCCTGTTTGCTACAACAGAGTTGTACCTAAAAACAGGGCAGCCTGTAGGGTCTAAAACTTTAAAGGAAAGTTTTTGCT
CTGATTTGAGTACGGCAACTATAAGAAATTACTTTGCAGAACTTGAAGCTGAAGGATTCTTAAAAAAAAATCATACTTCC
GGAGGGAGAATCCCTACAGACCTAGCATTACGTCACTATGTAGATCACCAAGAAGAATGCCCAGAAGCTGAGATTTCTGC
CCCCATTTTTGATAAGATCAGTCAGCTTCCTAGCGAAAGTCGCAATATTATCAAGGATCTACAAAAAGCTACGGAACTTC
TTGGAGAAATCCTAGACCTGCCTACGTTTTTTTCTTCCCCACGCTTTGAAAATGATTCCGTAACCAATATTCAAATTACA
CAGGTCGATAAGCAAAGAGCTGTCACCATCCTCTCTACGGAGTTTGGTCAGATCTTCACAGACACCCTATGGCTGCCTGA
AGCTTGCGATACTCTTTCTATCAAACGTATAGAAAAATTCCTGCAGAACTACATCCGAAAGCTCCCCACAAATGAGGAAC
TTTCGAAAAAAGAAGAACACCTGAGCATGTCCCTCTATAATGAGGTGGTTGTCCGCTATCTAACACGCTACTGCAACTTT
AGTGAAGAAGATCTCTATCAAACAGGAATGTCGAAACTACTGAAATACGAAGCGTTTAAAGATCCTGAAGTTCTAGCTCT
AGGACTCTCTCTTTTTGAAAATCGCAGACAAATGTGTGAGCTTCTAAATATAGGAATGCATAAAGGAAGAGCTACAGCGT
TCATAGGGAAGGAGCTTTCTGATATTTTAGGGACCTCGAATCCAGGATGTTCTGTAATTACTATTCCCTATTATATGAAT
CGCTCTCCACTCGGAGCTTTAGGTATCCTAGGCCCGATCAATCTTCCTTATAAGGAAGCTCTTCCTTTGCTCAAACTATT
TGCGAATAAAATAAATGAAACCCTGACACAAAGTTTCTACAAATTTAAACTATCCTTCAGAAGACCACTCACCTCTAACT
GTAAGCTTTCGAATGAGCCTATTTTAAGAACGGAGTACTCTTCTATAAAACTATTACCCTCTAAGGAGACGTTATGA

Upstream 100 bases:

>100_bases
TTAGCCTAGCTCTTTGATCGCTGCCCTCCTCGTAAAAAAGTTAGCATTCATTCAATTCGAGTGCTAAATTCTCTTGACCT
TCTCGGGTTCTTTTCCTATA

Downstream 100 bases:

>100_bases
CAGATACCCCACCTGAAAATGAGGAACAACACGAAAGCAATGTTCAAAACGAAAATGAAGTTGAACATTTGCAACAGGAA
ATCGTCACCCTAAAAACCGA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLSVTIVLVGLEMARSKVSKRDSKILDILFATTELYLKTGQPVGSKTLKESFCSDLSTATIRNYFAELEAEGFLKKNHTS
GGRIPTDLALRHYVDHQEECPEAEISAPIFDKISQLPSESRNIIKDLQKATELLGEILDLPTFFSSPRFENDSVTNIQIT
QVDKQRAVTILSTEFGQIFTDTLWLPEACDTLSIKRIEKFLQNYIRKLPTNEELSKKEEHLSMSLYNEVVVRYLTRYCNF
SEEDLYQTGMSKLLKYEAFKDPEVLALGLSLFENRRQMCELLNIGMHKGRATAFIGKELSDILGTSNPGCSVITIPYYMN
RSPLGALGILGPINLPYKEALPLLKLFANKINETLTQSFYKFKLSFRRPLTSNCKLSNEPILRTEYSSIKLLPSKETL

Sequences:

>Translated_398_residues
MLSVTIVLVGLEMARSKVSKRDSKILDILFATTELYLKTGQPVGSKTLKESFCSDLSTATIRNYFAELEAEGFLKKNHTS
GGRIPTDLALRHYVDHQEECPEAEISAPIFDKISQLPSESRNIIKDLQKATELLGEILDLPTFFSSPRFENDSVTNIQIT
QVDKQRAVTILSTEFGQIFTDTLWLPEACDTLSIKRIEKFLQNYIRKLPTNEELSKKEEHLSMSLYNEVVVRYLTRYCNF
SEEDLYQTGMSKLLKYEAFKDPEVLALGLSLFENRRQMCELLNIGMHKGRATAFIGKELSDILGTSNPGCSVITIPYYMN
RSPLGALGILGPINLPYKEALPLLKLFANKINETLTQSFYKFKLSFRRPLTSNCKLSNEPILRTEYSSIKLLPSKETL
>Mature_398_residues
MLSVTIVLVGLEMARSKVSKRDSKILDILFATTELYLKTGQPVGSKTLKESFCSDLSTATIRNYFAELEAEGFLKKNHTS
GGRIPTDLALRHYVDHQEECPEAEISAPIFDKISQLPSESRNIIKDLQKATELLGEILDLPTFFSSPRFENDSVTNIQIT
QVDKQRAVTILSTEFGQIFTDTLWLPEACDTLSIKRIEKFLQNYIRKLPTNEELSKKEEHLSMSLYNEVVVRYLTRYCNF
SEEDLYQTGMSKLLKYEAFKDPEVLALGLSLFENRRQMCELLNIGMHKGRATAFIGKELSDILGTSNPGCSVITIPYYMN
RSPLGALGILGPINLPYKEALPLLKLFANKINETLTQSFYKFKLSFRRPLTSNCKLSNEPILRTEYSSIKLLPSKETL

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_CHLPN (Q9Z850)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A86553
- PIR:   B81598
- PIR:   G72070
- RefSeq:   NP_224697.1
- RefSeq:   NP_300556.1
- RefSeq:   NP_444804.1
- RefSeq:   NP_876793.1
- GeneID:   1467200
- GeneID:   894870
- GeneID:   919255
- GeneID:   962915
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0253
- KEGG:   cpn:CPn0501
- KEGG:   cpt:CpB0521
- TIGR:   CP_0253
- HOGENOM:   HBG414062
- OMA:   VHYKLRT
- ProtClustDB:   PRK00082
- BioCyc:   CPNE115711:CP_0253-MONOMER
- BioCyc:   CPNE115713:CPN0501-MONOMER
- BioCyc:   CPNE138677:CPJ0501-MONOMER
- BioCyc:   CPNE182082:CPB0521-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 45157; Mature: 45157

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVTIVLVGLEMARSKVSKRDSKILDILFATTELYLKTGQPVGSKTLKESFCSDLSTAT
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IRNYFAELEAEGFLKKNHTSGGRIPTDLALRHYVDHQEECPEAEISAPIFDKISQLPSES
HHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCHH
RNIIKDLQKATELLGEILDLPTFFSSPRFENDSVTNIQITQVDKQRAVTILSTEFGQIFT
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEEECHHHHEEHEEHHHHHHHH
DTLWLPEACDTLSIKRIEKFLQNYIRKLPTNEELSKKEEHLSMSLYNEVVVRYLTRYCNF
HHCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SEEDLYQTGMSKLLKYEAFKDPEVLALGLSLFENRRQMCELLNIGMHKGRATAFIGKELS
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DILGTSNPGCSVITIPYYMNRSPLGALGILGPINLPYKEALPLLKLFANKINETLTQSFY
HHHCCCCCCCEEEEECCEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFKLSFRRPLTSNCKLSNEPILRTEYSSIKLLPSKETL
HHHHHHCCCCCCCCCCCCCCCEEECCCCEEECCCCCCC
>Mature Secondary Structure
MLSVTIVLVGLEMARSKVSKRDSKILDILFATTELYLKTGQPVGSKTLKESFCSDLSTAT
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IRNYFAELEAEGFLKKNHTSGGRIPTDLALRHYVDHQEECPEAEISAPIFDKISQLPSES
HHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHCCCHH
RNIIKDLQKATELLGEILDLPTFFSSPRFENDSVTNIQITQVDKQRAVTILSTEFGQIFT
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEEECHHHHEEHEEHHHHHHHH
DTLWLPEACDTLSIKRIEKFLQNYIRKLPTNEELSKKEEHLSMSLYNEVVVRYLTRYCNF
HHCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SEEDLYQTGMSKLLKYEAFKDPEVLALGLSLFENRRQMCELLNIGMHKGRATAFIGKELS
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DILGTSNPGCSVITIPYYMNRSPLGALGILGPINLPYKEALPLLKLFANKINETLTQSFY
HHHCCCCCCCEEEEECCEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFKLSFRRPLTSNCKLSNEPILRTEYSSIKLLPSKETL
HHHHHHCCCCCCCCCCCCCCCEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362