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The map label for this gene is hemN_1

Identifier: 15835913

GI number: 15835913

Start: 426467

End: 427588

Strand: Direct

Name: hemN_1

Synonym: CPj0380

Alternate gene names: 15835913

Gene position: 426467-427588 (Clockwise)

Preceding gene: 15835912

Following gene: 15835921

Centisome position: 34.77

GC content: 44.47

Gene sequence:

>1122_bases
ATGAATGGTAAGGCTCCCCTAGCTCTTTATATTCATATTCCCTTCTGCACAAAAAAATGTCGCTATTGCAGTTTTTATAC
AATCCCCTACAAAAGTGAATCTGTATCGCTCTATTGTAATGCTGTAATTCAAGAGGGGCTAAGAAAGCTAGCCCCCATCC
AAGAGACGCATTTCATAGAGACTGTGTTTTTTGGAGGGGGAACACCTTCATTAGTTTCTCCTCTTGATCTTAAGCGCATC
CTCAAAGAGCTAGCCCCACATGCCCGGGAAATTACTTTAGAGGCCAACCCCGAAAATCTCACCGTAAGCTATCTACGTCA
ACTACAAGAGACTCCAATAAATAGAATTAGCGTTGGCGTACAAACCTTCGACGACTCTATCCTACAGCTCCTCGGAAGAA
CGCATTCTTCATCTGCGGCAATCACAGCACTGCAAGAATGCCAGAATCACGGATTCTCTAATCTTTCTATAGACCTAATC
TACGGACTGCCCACACAGTCTTTGGAGATATTCCTAAGCGACCTACATCAAGCTCTGACTCTCCCTATCACTCACATTTC
TCTATACAACCTCACTATAGATCCCCACACCTCCTTCTATAAACACCGCAAAATTCTAGTCCCCACAATTGCCCAAGAAG
AAATTCTAGCTGAGATGAGCCTCCTTGCTGAAAATCTCCTACTCTCCCAAGGGTTCCAACGCTATGAACTTGCTTCATAT
GCCAAGCCAGATTACCCCGCAAAGCACAACCTCTATTACTGGACAGATCGCCCTTTCTTAGGCTTAGGAGTTTCAGCTTC
GCAATACCTTCACGGAGAGCGGTCAAAAAATTATAGTCATATTTCTCACTATCTACGTGCTGTACGTAAGAATCTCCCTA
CCCAAGAGACCTCAGAAATTCTCCCAAAAAAAGAACGAATCAAAGAAGCCTTAGCCCTGCGACTCCGACTCCTTGAAGGA
GCAGACCTCGCGGAGTTCCCCTCCACACTTATCTCCATGCTTACGCAAGATGTAAAATTACAAAACCTATTCAGTGTGCA
TGGACAATGTCTTGCCCTAAATAGACAGGGCCGTCTCTTCCACGATACAATAGCGGAAGAGATTATGGGATATTCCTTCT
AA

Upstream 100 bases:

>100_bases
GATGGGGCAGTAGAAGTCGACTATTCCCACGAAGACGATGAAGACCCTTTCAGCGATCGCAATCGCTGGAGACGCGGTGG
TATCATTGATCCCGATGCTA

Downstream 100 bases:

>100_bases
TCCCTGCGGAAGGCTAAAACCTAGACTCTGCCCTTCGGACTCCTGATGCTCCGGGAAACATCAGAGAACTCTTAAAGGTA
AAGCTTCTTTCTCGGTCTTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MNGKAPLALYIHIPFCTKKCRYCSFYTIPYKSESVSLYCNAVIQEGLRKLAPIQETHFIETVFFGGGTPSLVSPLDLKRI
LKELAPHAREITLEANPENLTVSYLRQLQETPINRISVGVQTFDDSILQLLGRTHSSSAAITALQECQNHGFSNLSIDLI
YGLPTQSLEIFLSDLHQALTLPITHISLYNLTIDPHTSFYKHRKILVPTIAQEEILAEMSLLAENLLLSQGFQRYELASY
AKPDYPAKHNLYYWTDRPFLGLGVSASQYLHGERSKNYSHISHYLRAVRKNLPTQETSEILPKKERIKEALALRLRLLEG
ADLAEFPSTLISMLTQDVKLQNLFSVHGQCLALNRQGRLFHDTIAEEIMGYSF

Sequences:

>Translated_373_residues
MNGKAPLALYIHIPFCTKKCRYCSFYTIPYKSESVSLYCNAVIQEGLRKLAPIQETHFIETVFFGGGTPSLVSPLDLKRI
LKELAPHAREITLEANPENLTVSYLRQLQETPINRISVGVQTFDDSILQLLGRTHSSSAAITALQECQNHGFSNLSIDLI
YGLPTQSLEIFLSDLHQALTLPITHISLYNLTIDPHTSFYKHRKILVPTIAQEEILAEMSLLAENLLLSQGFQRYELASY
AKPDYPAKHNLYYWTDRPFLGLGVSASQYLHGERSKNYSHISHYLRAVRKNLPTQETSEILPKKERIKEALALRLRLLEG
ADLAEFPSTLISMLTQDVKLQNLFSVHGQCLALNRQGRLFHDTIAEEIMGYSF
>Mature_373_residues
MNGKAPLALYIHIPFCTKKCRYCSFYTIPYKSESVSLYCNAVIQEGLRKLAPIQETHFIETVFFGGGTPSLVSPLDLKRI
LKELAPHAREITLEANPENLTVSYLRQLQETPINRISVGVQTFDDSILQLLGRTHSSSAAITALQECQNHGFSNLSIDLI
YGLPTQSLEIFLSDLHQALTLPITHISLYNLTIDPHTSFYKHRKILVPTIAQEEILAEMSLLAENLLLSQGFQRYELASY
AKPDYPAKHNLYYWTDRPFLGLGVSASQYLHGERSKNYSHISHYLRAVRKNLPTQETSEILPKKERIKEALALRLRLLEG
ADLAEFPSTLISMLTQDVKLQNLFSVHGQCLALNRQGRLFHDTIAEEIMGYSF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=266, Percent_Identity=35.7142857142857, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1789325, Length=335, Percent_Identity=35.8208955223881, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87082341, Length=303, Percent_Identity=28.3828382838284, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42265; Mature: 42265

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKAPLALYIHIPFCTKKCRYCSFYTIPYKSESVSLYCNAVIQEGLRKLAPIQETHFIE
CCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEE
TVFFGGGTPSLVSPLDLKRILKELAPHAREITLEANPENLTVSYLRQLQETPINRISVGV
EEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHH
QTFDDSILQLLGRTHSSSAAITALQECQNHGFSNLSIDLIYGLPTQSLEIFLSDLHQALT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
LPITHISLYNLTIDPHTSFYKHRKILVPTIAQEEILAEMSLLAENLLLSQGFQRYELASY
CCEEEEEEEEEEECCCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
AKPDYPAKHNLYYWTDRPFLGLGVSASQYLHGERSKNYSHISHYLRAVRKNLPTQETSEI
CCCCCCCCCCEEEEECCCEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LPKKERIKEALALRLRLLEGADLAEFPSTLISMLTQDVKLQNLFSVHGQCLALNRQGRLF
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHH
HDTIAEEIMGYSF
HHHHHHHHHCCCC
>Mature Secondary Structure
MNGKAPLALYIHIPFCTKKCRYCSFYTIPYKSESVSLYCNAVIQEGLRKLAPIQETHFIE
CCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEE
TVFFGGGTPSLVSPLDLKRILKELAPHAREITLEANPENLTVSYLRQLQETPINRISVGV
EEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHH
QTFDDSILQLLGRTHSSSAAITALQECQNHGFSNLSIDLIYGLPTQSLEIFLSDLHQALT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
LPITHISLYNLTIDPHTSFYKHRKILVPTIAQEEILAEMSLLAENLLLSQGFQRYELASY
CCEEEEEEEEEEECCCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
AKPDYPAKHNLYYWTDRPFLGLGVSASQYLHGERSKNYSHISHYLRAVRKNLPTQETSEI
CCCCCCCCCCEEEEECCCEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LPKKERIKEALALRLRLLEGADLAEFPSTLISMLTQDVKLQNLFSVHGQCLALNRQGRLF
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHH
HDTIAEEIMGYSF
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]