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The map label for this gene is xerC

Identifier: 15835561

GI number: 15835561

Start: 36329

End: 37267

Strand: Reverse

Name: xerC

Synonym: CPj0024

Alternate gene names: 15835561

Gene position: 37267-36329 (Counterclockwise)

Preceding gene: 15835562

Following gene: 15835560

Centisome position: 3.04

GC content: 42.07

Gene sequence:

>939_bases
ATGATTGCCTCTATCTATTCGTTCTTAGACTATTTGAAAATGGTAAAAAGTGCCTCTCCGCATACATTAAGAAATTATTG
TCTAGATCTTAATGGATTGAAAATTTTTTTAGAGGAACGTGGTAACCTCGCTCCTTCTTCTCCTTTACAGTTAGCCACAG
AGAAGCGCAAAGTCTCTGAACTTCCTTTTTCCTTATTCACCAAAGAGCATGTACGCATGTACATCGCGAAACTGATAGAA
AATGGCAAAGCTAAGAGAACAATTAAGCGTTGCCTCTCTTCCATTAAAAGCTTTGCCCATTACTGTGTTATTCAAAAGAT
TCTTTTGGAAAATCCTGCGGAAACTATCCACGGACCTCGTCTTCCTAAGGAGCTGCCTTCCCCGATGACCTATGCGCAAG
TTGAAGTGCTGATGGCGACTCCTGACATTTCTAAATATCACGGACTTCGTGATCGCTGTCTCATGGAGCTGTTCTATAGT
TCGGGTTTGAGGATTAGTGAGATTGTCGCTGTTAATAAACAGGACTTTGATTTGAGTACTCATCTGATTCGCATCCGTGG
GAAAGGGAAAAAAGAAAGGATTATTCCCGTGACATCGAATGCCATACAATGGATCCAAATCTACCTGAACCATCCGGATA
GAAAGCGTTTGGAAAAGGATCCTCAAGCCATCTTTCTCAATCGCTTTGGGAGGCGCATTTCAACACGATCTATTGACAGA
AGTTTTCAAGAATATCTTCGACGTTCTGGACTTTCAGGGCACATCACCCCCCATACAATCCGTCACACTATAGCCACCCA
TTGGCTAGAGAGTGGTATGGATTTAAAAACAATCCAAGCACTTCTTGGTCATAGTTCTTTAGAGACAACAACGGTCTATA
CGCAAGTCTCTGTAAAGTTAAAAAAACAGACCCACCAAGAAGCCCATCCCCATGCCTAA

Upstream 100 bases:

>100_bases
TCTTCTAAATAAATAGCTCGGAAAGAATAGTAAGAAGCTAGCCTTCCTAAAGCTAAGAGGAAGTCTTTTTACGATCTTTA
TTGTAAGGTAAAGAGAAGTT

Downstream 100 bases:

>100_bases
GAGAACAGGGCAAAGCTCTTGTACTCTAAGCAGCACTTTGTTATGCTGTCTGCTATGAGCATAGTATTAGATAAAATTGG
CAAATCTTTAGGCACTCGAA

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MIASIYSFLDYLKMVKSASPHTLRNYCLDLNGLKIFLEERGNLAPSSPLQLATEKRKVSELPFSLFTKEHVRMYIAKLIE
NGKAKRTIKRCLSSIKSFAHYCVIQKILLENPAETIHGPRLPKELPSPMTYAQVEVLMATPDISKYHGLRDRCLMELFYS
SGLRISEIVAVNKQDFDLSTHLIRIRGKGKKERIIPVTSNAIQWIQIYLNHPDRKRLEKDPQAIFLNRFGRRISTRSIDR
SFQEYLRRSGLSGHITPHTIRHTIATHWLESGMDLKTIQALLGHSSLETTTVYTQVSVKLKKQTHQEAHPHA

Sequences:

>Translated_312_residues
MIASIYSFLDYLKMVKSASPHTLRNYCLDLNGLKIFLEERGNLAPSSPLQLATEKRKVSELPFSLFTKEHVRMYIAKLIE
NGKAKRTIKRCLSSIKSFAHYCVIQKILLENPAETIHGPRLPKELPSPMTYAQVEVLMATPDISKYHGLRDRCLMELFYS
SGLRISEIVAVNKQDFDLSTHLIRIRGKGKKERIIPVTSNAIQWIQIYLNHPDRKRLEKDPQAIFLNRFGRRISTRSIDR
SFQEYLRRSGLSGHITPHTIRHTIATHWLESGMDLKTIQALLGHSSLETTTVYTQVSVKLKKQTHQEAHPHA
>Mature_312_residues
MIASIYSFLDYLKMVKSASPHTLRNYCLDLNGLKIFLEERGNLAPSSPLQLATEKRKVSELPFSLFTKEHVRMYIAKLIE
NGKAKRTIKRCLSSIKSFAHYCVIQKILLENPAETIHGPRLPKELPSPMTYAQVEVLMATPDISKYHGLRDRCLMELFYS
SGLRISEIVAVNKQDFDLSTHLIRIRGKGKKERIIPVTSNAIQWIQIYLNHPDRKRLEKDPQAIFLNRFGRRISTRSIDR
SFQEYLRRSGLSGHITPHTIRHTIATHWLESGMDLKTIQALLGHSSLETTTVYTQVSVKLKKQTHQEAHPHA

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=309, Percent_Identity=33.3333333333333, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1789261, Length=313, Percent_Identity=31.9488817891374, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1790768, Length=148, Percent_Identity=30.4054054054054, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790767, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_CHLPN (Q9Z9F7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86494
- PIR:   F72129
- RefSeq:   NP_224232.1
- RefSeq:   NP_300085.1
- RefSeq:   NP_445294.1
- RefSeq:   NP_876304.1
- ProteinModelPortal:   Q9Z9F7
- SMR:   Q9Z9F7
- GeneID:   1466711
- GeneID:   895001
- GeneID:   918815
- GeneID:   963152
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0752
- KEGG:   cpn:CPn0024
- KEGG:   cpt:CpB0028
- TIGR:   CP_0752
- HOGENOM:   HBG727654
- OMA:   PHTLRNY
- PhylomeDB:   Q9Z9F7
- ProtClustDB:   PRK00236
- BioCyc:   CPNE115711:CP_0752-MONOMER
- BioCyc:   CPNE115713:CPN0024-MONOMER
- BioCyc:   CPNE138677:CPJ0024-MONOMER
- BioCyc:   CPNE182082:CPB0028-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 35852; Mature: 35852

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: ACT_SITE 164-164 ACT_SITE 188-188 ACT_SITE 258-258 ACT_SITE 261-261 ACT_SITE 284-284 ACT_SITE 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASIYSFLDYLKMVKSASPHTLRNYCLDLNGLKIFLEERGNLAPSSPLQLATEKRKVSE
CHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
LPFSLFTKEHVRMYIAKLIENGKAKRTIKRCLSSIKSFAHYCVIQKILLENPAETIHGPR
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
LPKELPSPMTYAQVEVLMATPDISKYHGLRDRCLMELFYSSGLRISEIVAVNKQDFDLST
CCHHCCCCCCHHHEEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCHHHEEECCCCCCHHE
HLIRIRGKGKKERIIPVTSNAIQWIQIYLNHPDRKRLEKDPQAIFLNRFGRRISTRSIDR
EEEEEECCCCCCEEEEECHHHHHHHHHEECCCCHHHHHCCHHHHHHHHHCCHHHHHHHHH
SFQEYLRRSGLSGHITPHTIRHTIATHWLESGMDLKTIQALLGHSSLETTTVYTQVSVKL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEHHHHHH
KKQTHQEAHPHA
HHHHHHCCCCCC
>Mature Secondary Structure
MIASIYSFLDYLKMVKSASPHTLRNYCLDLNGLKIFLEERGNLAPSSPLQLATEKRKVSE
CHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
LPFSLFTKEHVRMYIAKLIENGKAKRTIKRCLSSIKSFAHYCVIQKILLENPAETIHGPR
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
LPKELPSPMTYAQVEVLMATPDISKYHGLRDRCLMELFYSSGLRISEIVAVNKQDFDLST
CCHHCCCCCCHHHEEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCHHHEEECCCCCCHHE
HLIRIRGKGKKERIIPVTSNAIQWIQIYLNHPDRKRLEKDPQAIFLNRFGRRISTRSIDR
EEEEEECCCCCCEEEEECHHHHHHHHHEECCCCHHHHHCCHHHHHHHHHCCHHHHHHHHH
SFQEYLRRSGLSGHITPHTIRHTIATHWLESGMDLKTIQALLGHSSLETTTVYTQVSVKL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEHHHHHH
KKQTHQEAHPHA
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362