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The map label for this gene is ubiE

Identifier: 15835327

GI number: 15835327

Start: 850419

End: 851138

Strand: Direct

Name: ubiE

Synonym: TC0712

Alternate gene names: 15835327

Gene position: 850419-851138 (Clockwise)

Preceding gene: 15835326

Following gene: 15835332

Centisome position: 79.26

GC content: 40.83

Gene sequence:

>720_bases
TTGCAGGTTTACAACAGTTTAAGAACTATTATGACAAACTTCCAAGACAAGCCGAACATCCGAATCATGTTTGATTCCCT
AGCACCCACCTACGATAAAATTAATAAAATTCTGTCGTTAGGTTTGCACCTCACATGGAATCATTCTTTTGTTTCTCTTT
TAGGTAGATCTGACCATTTATTGGATTTATGTGCTGGGACTGGACACGTGGCCTTGTCCTATATCCAAAAATATCCCCAA
GCTTCGGCGACGCTCGTTGATTTTTCAACCAAAATGCTAGAAAATGTTCAGGAATGCCATCCTTTAGCTCCTTTCTCCTA
CGTCATAAGCGATGTAACAAGCATGCCTCTTCCGAATGACACTTTTCATTTAGCTTCTATGGCATATGGACTCCGGAATC
TATCCTCCCCTCTTGAAGCGCTCAAGGAGGTACATAGGGTTTTAAAACCTAAAGGACGTTTAGGCATTCTTGAGCTGACT
CGTCCAGCAACTTATAACCCAGTCCACCTGTTACATAAACTCTATCTTAATCTAGTTGTCCCTAGTGTTGGAAGGTTTTA
TTCCGGGAACAGTTACGCTTACTCTTACTTAAAAGAAAGCATCCGAAACCTTCCCTGCGACACCTCTCTGGAAAGAGTTT
TTCACAAATCAGGGCTACACATTATCCGAAAACGAAAATTGCTCTTCGGAACTGCAACTATTTGGATTTTAGAAAAATAG

Upstream 100 bases:

>100_bases
GAGGAAATCTGGAGAAAAGCAGCCGCATTACTGAAGCTTCCAGAGTCACTAATGCAGCAATATTACTCTTTATGTCGTTA
CGAACTTTCTGAAGAAGATT

Downstream 100 bases:

>100_bases
AACTCACAAGATTTAACAAAAATGCTTATGAACGAGCCTTCTTACGACCACGCTTGGCAGCCTTTTTCGGCTTAACATCA
TCGTCATCATCATCGTCGTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQVYNSLRTIMTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHLLDLCAGTGHVALSYIQKYPQ
ASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPNDTFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELT
RPATYNPVHLLHKLYLNLVVPSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK

Sequences:

>Translated_239_residues
MQVYNSLRTIMTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHLLDLCAGTGHVALSYIQKYPQ
ASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPNDTFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELT
RPATYNPVHLLHKLYLNLVVPSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK
>Mature_239_residues
MQVYNSLRTIMTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHLLDLCAGTGHVALSYIQKYPQ
ASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPNDTFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELT
RPATYNPVHLLHKLYLNLVVPSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=254, Percent_Identity=28.3464566929134, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI48994983, Length=219, Percent_Identity=28.7671232876712, Blast_Score=110, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17557039, Length=221, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323526, Length=234, Percent_Identity=23.9316239316239, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641702, Length=241, Percent_Identity=29.045643153527, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27146; Mature: 27146

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVYNSLRTIMTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHL
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECHHHHHHHCCCCHH
LDLCAGTGHVALSYIQKYPQASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPND
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELTRPATYNPVHLLHKLYLNLVV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
PSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHEEEEEEEEEEC
>Mature Secondary Structure
MQVYNSLRTIMTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHL
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECHHHHHHHCCCCHH
LDLCAGTGHVALSYIQKYPQASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPND
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELTRPATYNPVHLLHKLYLNLVV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
PSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]