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The map label for this gene is xseA

Identifier: 15835222

GI number: 15835222

Start: 724412

End: 725962

Strand: Direct

Name: xseA

Synonym: TC0605

Alternate gene names: 15835222

Gene position: 724412-725962 (Clockwise)

Preceding gene: 15835221

Following gene: 15835223

Centisome position: 67.52

GC content: 39.91

Gene sequence:

>1551_bases
ATGTCGATAACATCTCCTCCTGTAGAAGTCTCTGTCCTTACAGATTCTATTAAGAATCTTTTAGAAAAAAATTTTCTTCG
GGTAGTGGTTAAAGGAGAACTCAGCAACGTCTCTTTGCAAACGAGTGGACACCTTTACTTTGCTATCAAAGATAGTAAGG
CTGTTCTCAATGGAGCCTTTTTTCATTTCCGCAGCAAATACTTTGATCGTAGGCCCAAAGACGGAGATTACGTGATTCTT
CACGGGAAACTCACCGTCTATGCTCCTAGAGGTCAATATCAAATCGTAGCCTATGCCCTTACCTTCTCTGGGGAAGGCAA
TTTGCTACAACAATTCGAAGAACGTAAACAACGTCTCGCTGCGGAAGGATATTTCGATCCCAAACGTAAGCGTCAGATTC
CTTCTGAAGCTAGAACAATAGGGGTCATCACAAGCCCTACAGGAGCTGTCATTCAGGATATTTTACGAGTTCTTTCTCGA
CGCTGTCACCAATTTCAAGTGATCCTATACCCAGTCACTGTACAAGGTCCTACTGCTGCTCAAGAAATTTCTCGAGCCAT
TCAAGTTTTCAATCAAGAAAACATTAAAATCGACACGCTCATTGTTGCCAGGGGTGGTGGTAGCATCGAAGATCTTTGGG
CCTTTAATGAAGAAATCCTAGTCAAAGCTATTGCAGCAAGTTCTATCCCTATTATTTCTGCTGTTGGTCATGAAACCGAT
TTTACTCTTTGTGACTTTGCTGCAGATGTTCGCGCACCAACCCCCTCGGCTGCAGCAGAAATTGTATGTAAAAGCAGTGA
ACAATATCACCAAGAGCTTCAAAATTTACTTCGACATCTCTCATCCCACTCGAGACAATTTATTGCTGCAAAAAAGAATC
TTCTCTCTCATTGGAAAAAGCATCTTGCTACAGCAGATTTTTACCATACAGCACAACAAACTTTGGATTACACCCGACTA
TCCTTAGAAAGAACTCTAGATGCTAAACTCGAACATTATAAACAGCATCTCGCACAATATAAGCGTTGGCTAAAGAGCGA
TATCCTAATCCGTGTAGAAAAACACCTGTCTAATCTCAATCAAGCTCTTGAATCAGCTATTAAAAATAAACTTTATTCTA
ATAAAGTCTCTTTACATCAGCTATATACTTCTCGTTTCAAAAATGAATTACCTAATTTACAACATCGCACTCAACACGCA
AAACATCTTTTAAACCAACTTTCTCGTAGATTGCACTTTGTAATGGCAAACTCACAAGAAACGAAATTACAAAGGTTTGC
TCGCTTACAAGAAGAATTTTCTTTCATGATACAGCACCTTTTAACCAAAGCTAAGGAACGCTGCCAGTCCGTACAAGAAC
AGATGGCCTCTCTGAATCCAAAAAATGTTTTGAAAAGAGGTTTTGCCCAGCTCTTTGACTTTAATAAACACTCTGTTATC
ATTTCAGCTGAATCTCTTAAGCAAAGCGATCTTGTGCGGGTCTGCCTCCAAGACGGTGAAGCAGTTTTATCAGTAAAAGA
AGTTTGGCTGAACAATGACAAAAAAGGCTAA

Upstream 100 bases:

>100_bases
TCCGGACGTTAACGGACTTTTAGTTGGAGGAGCTTCTCTATCTGTAGAGAGTTTTCTTGCTATTATACAACAAATCGCTG
TCTCATAAATCATAGTACCT

Downstream 100 bases:

>100_bases
AAACGTGGAAAAAGTTCCCTTTGAAGACGCAATGAAACGCTTGGAAGAGATTATAGATCTCATGAATCAGCCAACAACGG
CTTTAGAAGCTTCTCTCGCT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRRPKDGDYVIL
HGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSR
RCHQFQVILYPVTVQGPTAAQEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETD
FTLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKKHLATADFYHTAQQTLDYTRL
SLERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLNQALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHA
KHLLNQLSRRLHFVMANSQETKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVI
ISAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG

Sequences:

>Translated_516_residues
MSITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRRPKDGDYVIL
HGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSR
RCHQFQVILYPVTVQGPTAAQEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETD
FTLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKKHLATADFYHTAQQTLDYTRL
SLERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLNQALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHA
KHLLNQLSRRLHFVMANSQETKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVI
ISAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG
>Mature_515_residues
SITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRRPKDGDYVILH
GKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSRR
CHQFQVILYPVTVQGPTAAQEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETDF
TLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKKHLATADFYHTAQQTLDYTRLS
LERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLNQALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHAK
HLLNQLSRRLHFVMANSQETKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVII
SAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=328, Percent_Identity=42.9878048780488, Blast_Score=262, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CHLMU (Q9PK65)

Other databases:

- EMBL:   AE002160
- PIR:   B81684
- RefSeq:   NP_296981.1
- GeneID:   1245967
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0605
- TIGR:   TC_0605
- HOGENOM:   HBG634411
- OMA:   DRRPKDG
- PhylomeDB:   Q9PK65
- ProtClustDB:   PRK00286
- BioCyc:   CMUR243161:TC_0605-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L

EC number: =3.1.11.6

Molecular weight: Translated: 58883; Mature: 58752

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAF
CCCCCCCCEEHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCEEEEEEECCCHHHHHHH
FHFRSKYFDRRPKDGDYVILHGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLA
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
AEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSRRCHQFQVILYPVTVQGPTAA
HCCCCCCHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHH
QEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETD
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCC
FTLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKK
CCHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLATADFYHTAQQTLDYTRLSLERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHAKHLLNQLSRRLHFVMANSQE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
ISAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG
EEHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SITSPPVEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAF
CCCCCCCEEHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCEEEEEEECCCHHHHHHH
FHFRSKYFDRRPKDGDYVILHGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLA
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
AEGYFDPKRKRQIPSEARTIGVITSPTGAVIQDILRVLSRRCHQFQVILYPVTVQGPTAA
HCCCCCCHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHH
QEISRAIQVFNQENIKIDTLIVARGGGSIEDLWAFNEEILVKAIAASSIPIISAVGHETD
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCC
FTLCDFAADVRAPTPSAAAEIVCKSSEQYHQELQNLLRHLSSHSRQFIAAKKNLLSHWKK
CCHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLATADFYHTAQQTLDYTRLSLERTLDAKLEHYKQHLAQYKRWLKSDILIRVEKHLSNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALESAIKNKLYSNKVSLHQLYTSRFKNELPNLQHRTQHAKHLLNQLSRRLHFVMANSQE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
TKLQRFARLQEEFSFMIQHLLTKAKERCQSVQEQMASLNPKNVLKRGFAQLFDFNKHSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
ISAESLKQSDLVRVCLQDGEAVLSVKEVWLNNDKKG
EEHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935