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Identifier: 15835150

GI number: 15835150

Start: 642562

End: 643260

Strand: Direct

Name: Not Available

Synonym: TC0532

Alternate gene names: 15835150

Gene position: 642562-643260 (Clockwise)

Preceding gene: 15835149

Following gene: 15835151

Centisome position: 59.89

GC content: 37.77

Gene sequence:

>699_bases
GTGCCAGATTTAATTTTTTATGATACGGAAACAACTGGGACACAAATTGACAAGGATCGCATAGTGGAAATAGCTGCTTA
CAATGGAACCACAGGCGAATCTTTTCAAACTTTGGTAAATCCAGAAATTCCTATTCCTGCTGAAGCAACCAAAATTCATG
GGATTACAACTTCAGAAGTTGCCAACGCCCCTAAATTTCCAGAAGCATATCAGCAATTCAGTGATTTTTGTGGCACAGAT
AACATTCTTGTAGCTCATAATAATAATGCTTTTGACTACCCTTTGTTACTTCGTGAATGTCGAAGACATGGATTGCCCGA
ACCGCAGCTTCGTACGATTGATTCTTTAAAATGGGCGAAAAAATATCGAACAGATTTGCCTCAACATAGCCTTCAGTATC
TTCGTCAAGTCTATGGATTTGAAGAGAATAATGCACACCGGGCTTTAGATGACGTAATTACTCTTCATAGAGTATTTTCC
GTATTAGTCGGAGATTTATCTCCAGATCAGATTTATAATCTGCTAAATGAAACATGCCATCCTAGAGTCTTTAAAATGCC
TTTCGGTAAATATAAGGGGAAACCTCTTTCTGAAGTCCCTTCTAGTTACATTGCTTGGTTACAAAAAGGAGATTACCTGT
TACAACCAGAGAATAAAGAAATTAAAGCAGCTATCGAGGCTTATCAACAACTCAAATGA

Upstream 100 bases:

>100_bases
GTTGATCTCGACAGGGAATATGGATCTCGATGAATTAAAAAAACAAGCGAACCAGGAAAATAATCAAACTAATTAAATAA
GAAAATTTTTTGAGGGACCT

Downstream 100 bases:

>100_bases
CTTTCTCCGTAGCTTTTTCCCCTTGTCCAAATGATATTTTTTTGTTTAGGTCTTTCTTGGAAAAACATGAAGGGGCCCCT
TCTTTGCGCCAAATTATGAT

Product: DNA polymerase III subunit epsilon

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MPDLIFYDTETTGTQIDKDRIVEIAAYNGTTGESFQTLVNPEIPIPAEATKIHGITTSEVANAPKFPEAYQQFSDFCGTD
NILVAHNNNAFDYPLLLRECRRHGLPEPQLRTIDSLKWAKKYRTDLPQHSLQYLRQVYGFEENNAHRALDDVITLHRVFS
VLVGDLSPDQIYNLLNETCHPRVFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK

Sequences:

>Translated_232_residues
MPDLIFYDTETTGTQIDKDRIVEIAAYNGTTGESFQTLVNPEIPIPAEATKIHGITTSEVANAPKFPEAYQQFSDFCGTD
NILVAHNNNAFDYPLLLRECRRHGLPEPQLRTIDSLKWAKKYRTDLPQHSLQYLRQVYGFEENNAHRALDDVITLHRVFS
VLVGDLSPDQIYNLLNETCHPRVFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK
>Mature_231_residues
PDLIFYDTETTGTQIDKDRIVEIAAYNGTTGESFQTLVNPEIPIPAEATKIHGITTSEVANAPKFPEAYQQFSDFCGTDN
ILVAHNNNAFDYPLLLRECRRHGLPEPQLRTIDSLKWAKKYRTDLPQHSLQYLRQVYGFEENNAHRALDDVITLHRVFSV
LVGDLSPDQIYNLLNETCHPRVFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK

Specific function: Capable Of Degrading Both Single-Strand And Double- Strand DNA With 3' To 5' Polarity. Has Higher Affinity For ssDNA Ends Than For dsDNA. May Facilitate Recombinational Repair By Pre- Synaptic And/Or Post-Synaptic DNA Degradation. [C]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG [H]

EC number: 2.7.7.7

Molecular weight: Translated: 26517; Mature: 26386

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLIFYDTETTGTQIDKDRIVEIAAYNGTTGESFQTLVNPEIPIPAEATKIHGITTSEV
CCCEEEEECCCCCCCCCHHHEEEEEEECCCCCHHHHHHCCCCCCCCCCCCEECCCCHHHH
ANAPKFPEAYQQFSDFCGTDNILVAHNNNAFDYPLLLRECRRHGLPEPQLRTIDSLKWAK
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KYRTDLPQHSLQYLRQVYGFEENNAHRALDDVITLHRVFSVLVGDLSPDQIYNLLNETCH
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PRVFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDLIFYDTETTGTQIDKDRIVEIAAYNGTTGESFQTLVNPEIPIPAEATKIHGITTSEV
CCEEEEECCCCCCCCCHHHEEEEEEECCCCCHHHHHHCCCCCCCCCCCCEECCCCHHHH
ANAPKFPEAYQQFSDFCGTDNILVAHNNNAFDYPLLLRECRRHGLPEPQLRTIDSLKWAK
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KYRTDLPQHSLQYLRQVYGFEENNAHRALDDVITLHRVFSVLVGDLSPDQIYNLLNETCH
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PRVFKMPFGKYKGKPLSEVPSSYIAWLQKGDYLLQPENKEIKAAIEAYQQLK
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]