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The map label for this gene is dnaA

Identifier: 15835139

GI number: 15835139

Start: 630061

End: 631431

Strand: Reverse

Name: dnaA

Synonym: TC0521

Alternate gene names: 15835139

Gene position: 631431-630061 (Counterclockwise)

Preceding gene: 15835140

Following gene: 15835137

Centisome position: 58.85

GC content: 40.48

Gene sequence:

>1371_bases
ATGCGAGCTTGGGAAGAGTTCCTTTTGCTACAAGAAAAAGAAATTGGTACGGATACGGTCAATAAGTGGCTGAGGTCCTT
AAAGGTCCTATGCTTTGATGCGTGCAATCTGTATTTGGAAGCAAAGGATTCTTTCCAAGTAACTTGGTTCGAAGAACATA
TTCGCCATAAAGTTAAAGCTAATTTAATTAATAATAACGGGAAGCCAATTCGGGTGCGTGTGACTTCTTTGGATAAGTCT
ACGCCGTTTAAAGAGTCGCAAATTCAACAAGAGAAAACAGCATACTTCACAATGCAGTATGGGGACATTGATCCACAAAT
GTCTTTTGCAAATTTTCTTGTGACTCCAGAGAATGATTTGCCTGTTAGGATTCTTCAAGAATTCGCGAAAGTTTCTGAGC
AAGGTAAAGGGTTCCCATTTAATCCCATCTATTTGTTTGGCCCAGAGAGTTCTGGAAAAACTCATCTCATGCAAGCCGCT
GTTGGAATCTTGCGTGAAGCCGGAGTAAAAACCTTATACGTTTCTTCACAGCTATTCACAGAACATCTAGTATCTGCTAT
TCGTTCAGGTGAGATGCAACGTTTTCGTGCGTTTTATCGTAATGTAGAAGCGTTATTCATTGAAGATATAGAAGTTCTCT
CAGGGAAAGGGGCCACTCAAGAAGAATTTTTCCATACATTTAATTCTTTGCATACTGAAGGGAAATTAATTGTCATTTCT
TCTATCTTCGCTCCTGGAGATCTAAAAGCTATGGAAGAGCGGTTGATTAGCCGTTTCGAGTGGGGGATTGCGGTTCCTGT
TAGCCCTTTAACGAGAGAGGGACTGAAAAGCTTTTTAGAAAGAAGAATAGAACAACTTAACATTCGCATAGAAGAAACAG
CCCTGGATTTCCTCATACAGGCTTTATCTTCTCATATAAAATCTTTGCTACATGCACTCACAACTTTAGCGAAAAGGGTC
GCTTATAAAAAATTATCGCACCAACTACTATACCAAGGGGATGTAGAGGCTTTGCTGCAAGATGTCTTGCAGGCTGCAGA
GCATATCCGTTTAACCCCATCTGGTATTGTTCGTGCTACTGCTCAGTATTATGGAGTTTCTCCCGAAAATATTTTAGGCC
GTTCTCAGTCTAGGGAATATGTTCTTCCTAGACAGGTTGCTATGTTTCTGTGCAGGCAGAAACTTTCTTTATCGTATGTA
AAGATCGGAGAGGTTTTTTCGCGAGATCATTCTACCGTGATCTCCTCAATTCGAGCAATTTCGCAAAAGCTGGATGAAGA
TGATAGAGAAAGTGATGTCTCTTGTGGAGTACAAGAACTAACAAAGCGACTTTCATCTGCTTATCAGAGCTTGGACCTTA
TAGTAGACTAA

Upstream 100 bases:

>100_bases
ATTGTTAATAAGAAGAGATAGAGAACGCCAATAAAGGCAAATAGTTCTGTTTTTTAATTAGAATAGTTTTTATCAAAAAC
TATTTAGCTGAGATAGTTTT

Downstream 100 bases:

>100_bases
AAAGTAAGGAGGCGGTCAATGACCAGCCTCCTTAGTAGTTTTAAAATCCTGTTAAAAACTTTTTGTCTAGATTAAGCAAG
AGCAAGAAGTTGGTTCTTCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRAWEEFLLLQEKEIGTDTVNKWLRSLKVLCFDACNLYLEAKDSFQVTWFEEHIRHKVKANLINNNGKPIRVRVTSLDKS
TPFKESQIQQEKTAYFTMQYGDIDPQMSFANFLVTPENDLPVRILQEFAKVSEQGKGFPFNPIYLFGPESSGKTHLMQAA
VGILREAGVKTLYVSSQLFTEHLVSAIRSGEMQRFRAFYRNVEALFIEDIEVLSGKGATQEEFFHTFNSLHTEGKLIVIS
SIFAPGDLKAMEERLISRFEWGIAVPVSPLTREGLKSFLERRIEQLNIRIEETALDFLIQALSSHIKSLLHALTTLAKRV
AYKKLSHQLLYQGDVEALLQDVLQAAEHIRLTPSGIVRATAQYYGVSPENILGRSQSREYVLPRQVAMFLCRQKLSLSYV
KIGEVFSRDHSTVISSIRAISQKLDEDDRESDVSCGVQELTKRLSSAYQSLDLIVD

Sequences:

>Translated_456_residues
MRAWEEFLLLQEKEIGTDTVNKWLRSLKVLCFDACNLYLEAKDSFQVTWFEEHIRHKVKANLINNNGKPIRVRVTSLDKS
TPFKESQIQQEKTAYFTMQYGDIDPQMSFANFLVTPENDLPVRILQEFAKVSEQGKGFPFNPIYLFGPESSGKTHLMQAA
VGILREAGVKTLYVSSQLFTEHLVSAIRSGEMQRFRAFYRNVEALFIEDIEVLSGKGATQEEFFHTFNSLHTEGKLIVIS
SIFAPGDLKAMEERLISRFEWGIAVPVSPLTREGLKSFLERRIEQLNIRIEETALDFLIQALSSHIKSLLHALTTLAKRV
AYKKLSHQLLYQGDVEALLQDVLQAAEHIRLTPSGIVRATAQYYGVSPENILGRSQSREYVLPRQVAMFLCRQKLSLSYV
KIGEVFSRDHSTVISSIRAISQKLDEDDRESDVSCGVQELTKRLSSAYQSLDLIVD
>Mature_456_residues
MRAWEEFLLLQEKEIGTDTVNKWLRSLKVLCFDACNLYLEAKDSFQVTWFEEHIRHKVKANLINNNGKPIRVRVTSLDKS
TPFKESQIQQEKTAYFTMQYGDIDPQMSFANFLVTPENDLPVRILQEFAKVSEQGKGFPFNPIYLFGPESSGKTHLMQAA
VGILREAGVKTLYVSSQLFTEHLVSAIRSGEMQRFRAFYRNVEALFIEDIEVLSGKGATQEEFFHTFNSLHTEGKLIVIS
SIFAPGDLKAMEERLISRFEWGIAVPVSPLTREGLKSFLERRIEQLNIRIEETALDFLIQALSSHIKSLLHALTTLAKRV
AYKKLSHQLLYQGDVEALLQDVLQAAEHIRLTPSGIVRATAQYYGVSPENILGRSQSREYVLPRQVAMFLCRQKLSLSYV
KIGEVFSRDHSTVISSIRAISQKLDEDDRESDVSCGVQELTKRLSSAYQSLDLIVD

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=475, Percent_Identity=28, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA1_CHLMU (Q9PKE4)

Other databases:

- EMBL:   AE002160
- PIR:   F81692
- RefSeq:   NP_296898.1
- ProteinModelPortal:   Q9PKE4
- SMR:   Q9PKE4
- GeneID:   1245881
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0521
- TIGR:   TC_0521
- HOGENOM:   HBG414010
- OMA:   ENDLPFR
- ProtClustDB:   PRK12422
- BioCyc:   CMUR243161:TC_0521-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51937; Mature: 51937

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAWEEFLLLQEKEIGTDTVNKWLRSLKVLCFDACNLYLEAKDSFQVTWFEEHIRHKVKA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEHHHHHHHHHHHH
NLINNNGKPIRVRVTSLDKSTPFKESQIQQEKTAYFTMQYGDIDPQMSFANFLVTPENDL
HHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHEEEEEEECCCCCCCHHHHEEECCCCCC
PVRILQEFAKVSEQGKGFPFNPIYLFGPESSGKTHLMQAAVGILREAGVKTLYVSSQLFT
CHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
EHLVSAIRSGEMQRFRAFYRNVEALFIEDIEVLSGKGATQEEFFHTFNSLHTEGKLIVIS
HHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEE
SIFAPGDLKAMEERLISRFEWGIAVPVSPLTREGLKSFLERRIEQLNIRIEETALDFLIQ
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALSSHIKSLLHALTTLAKRVAYKKLSHQLLYQGDVEALLQDVLQAAEHIRLTPSGIVRAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCHHHHHHH
AQYYGVSPENILGRSQSREYVLPRQVAMFLCRQKLSLSYVKIGEVFSRDHSTVISSIRAI
HHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHH
SQKLDEDDRESDVSCGVQELTKRLSSAYQSLDLIVD
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAWEEFLLLQEKEIGTDTVNKWLRSLKVLCFDACNLYLEAKDSFQVTWFEEHIRHKVKA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEHHHHHHHHHHHH
NLINNNGKPIRVRVTSLDKSTPFKESQIQQEKTAYFTMQYGDIDPQMSFANFLVTPENDL
HHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHEEEEEEECCCCCCCHHHHEEECCCCCC
PVRILQEFAKVSEQGKGFPFNPIYLFGPESSGKTHLMQAAVGILREAGVKTLYVSSQLFT
CHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
EHLVSAIRSGEMQRFRAFYRNVEALFIEDIEVLSGKGATQEEFFHTFNSLHTEGKLIVIS
HHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEE
SIFAPGDLKAMEERLISRFEWGIAVPVSPLTREGLKSFLERRIEQLNIRIEETALDFLIQ
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ALSSHIKSLLHALTTLAKRVAYKKLSHQLLYQGDVEALLQDVLQAAEHIRLTPSGIVRAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCHHHHHHH
AQYYGVSPENILGRSQSREYVLPRQVAMFLCRQKLSLSYVKIGEVFSRDHSTVISSIRAI
HHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHH
SQKLDEDDRESDVSCGVQELTKRLSSAYQSLDLIVD
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935