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The map label for this gene is fabH

Identifier: 15835128

GI number: 15835128

Start: 616098

End: 617081

Strand: Reverse

Name: fabH

Synonym: TC0510

Alternate gene names: 15835128

Gene position: 617081-616098 (Counterclockwise)

Preceding gene: 15835133

Following gene: 15835127

Centisome position: 57.51

GC content: 43.6

Gene sequence:

>984_bases
GTGAGAGCGTCGATCTGGGGAACCGGTTCGTATTTGCCTAAAAAAGTTTTGACAAACGCAGATTTGGAGAAAATGGTTGA
GACTTCTGATGAATGGATCTCGACTAGGACAGGGATTAAAGAACGTAGGATAGCTTCGGCTGAAGAGTTTTCATCCTTTA
TGGGAGCAAAAGCTGCGGAAAAGGCTATAGAGGCGGCTAAAATCTCCAAAAGCCAGATAGATTGCATTGTGTTTGCTACT
GCAGCTCCAGATTATATTTTCCCATCTAGTGCCGCTTTAGCCCAGGCCTATTTAGGGATTAAAGAGGTGCCTGCTTTTGA
TTGTTTAGTTGCATGTACGGGCTTTCTGTATGGGTTGTCTATAGCTAAGGCGTATGTTGAAGCTGGGATGTATCAGTGTG
TCCTTGTGATTGCAGCAGACAAATTATCTTCCTTTGTCAATTACGAAGATCGTAATACTTGTGTATTGTTTGGAGATGGG
GGTTCGGCTTGTGTTGTCGGTCCTTCAAGACCAGGATCTTTAAAAATATCCAAAGTGAACTTGGGAGCGGATGGAAAACA
AGGAGACCTTTTACGGCTACCAGCAGGAGGAAGTCGTTGTCCAGCCTCTCAGGATACCATACAAAATCAGCAACATTTCA
TTACCATGGAAGGTAAGGAGGTGTTTAAGCATGCAGTGCGTCGAATGGAGTTTGCTGCTAAAACATGCATTACGGAAGCT
GGTTTGCAAGAGGAAGATATAGACTGGTTGGTTCCTCATCAGGCGAATGAACGTATTATTGATGCAATTGCAAAACGGTT
TGCGGTTGAGGATTCACGAGTGTTTAAAACTCTCGCTAAATATGGGAATACTGCAGCTTCTTCTGTAGGAATTGCATTAG
ACGAGCTATTGCGTACGCACGATATTCATTCGAAAGAGCGACTATTGTTAGTTGCCTTTGGAGGGGGATTGTCTTGGGGA
GCTGTGATTTTACAGCAAATGTAA

Upstream 100 bases:

>100_bases
GATTATGGGGATAGATGCAAAATAAAGGTTAGGGTATAAAACTCCTCTAACAGTATACTCGGTTTTTTCTTTTTGTTTGC
AGGTGCATGTGAAAAAAGAT

Downstream 100 bases:

>100_bases
TAGAGGAGACCATGTTATGGAGCGTATAGGGTTGCTATTCCCTGGTCAGGGTAGTCAATTCGTTGGAATGGGCAAGGATC
TTTATCAACAGTATCCAGAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MRASIWGTGSYLPKKVLTNADLEKMVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAEKAIEAAKISKSQIDCIVFAT
AAPDYIFPSSAALAQAYLGIKEVPAFDCLVACTGFLYGLSIAKAYVEAGMYQCVLVIAADKLSSFVNYEDRNTCVLFGDG
GSACVVGPSRPGSLKISKVNLGADGKQGDLLRLPAGGSRCPASQDTIQNQQHFITMEGKEVFKHAVRRMEFAAKTCITEA
GLQEEDIDWLVPHQANERIIDAIAKRFAVEDSRVFKTLAKYGNTAASSVGIALDELLRTHDIHSKERLLLVAFGGGLSWG
AVILQQM

Sequences:

>Translated_327_residues
MRASIWGTGSYLPKKVLTNADLEKMVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAEKAIEAAKISKSQIDCIVFAT
AAPDYIFPSSAALAQAYLGIKEVPAFDCLVACTGFLYGLSIAKAYVEAGMYQCVLVIAADKLSSFVNYEDRNTCVLFGDG
GSACVVGPSRPGSLKISKVNLGADGKQGDLLRLPAGGSRCPASQDTIQNQQHFITMEGKEVFKHAVRRMEFAAKTCITEA
GLQEEDIDWLVPHQANERIIDAIAKRFAVEDSRVFKTLAKYGNTAASSVGIALDELLRTHDIHSKERLLLVAFGGGLSWG
AVILQQM
>Mature_327_residues
MRASIWGTGSYLPKKVLTNADLEKMVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAEKAIEAAKISKSQIDCIVFAT
AAPDYIFPSSAALAQAYLGIKEVPAFDCLVACTGFLYGLSIAKAYVEAGMYQCVLVIAADKLSSFVNYEDRNTCVLFGDG
GSACVVGPSRPGSLKISKVNLGADGKQGDLLRLPAGGSRCPASQDTIQNQQHFITMEGKEVFKHAVRRMEFAAKTCITEA
GLQEEDIDWLVPHQANERIIDAIAKRFAVEDSRVFKTLAKYGNTAASSVGIALDELLRTHDIHSKERLLLVAFGGGLSWG
AVILQQM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=326, Percent_Identity=47.239263803681, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CHLMU (Q9PKF5)

Other databases:

- EMBL:   AE002160
- PIR:   G81695
- RefSeq:   NP_296887.1
- ProteinModelPortal:   Q9PKF5
- SMR:   Q9PKF5
- GeneID:   1245870
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0510
- TIGR:   TC_0510
- HOGENOM:   HBG649927
- OMA:   CIALDEL
- PhylomeDB:   Q9PKF5
- ProtClustDB:   PRK09352
- BioCyc:   CMUR243161:TC_0510-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35373; Mature: 35373

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 253-253 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASIWGTGSYLPKKVLTNADLEKMVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAE
CCCCCCCCCCCCHHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHCCHHHHHHHHCHHHHH
KAIEAAKISKSQIDCIVFATAAPDYIFPSSAALAQAYLGIKEVPAFDCLVACTGFLYGLS
HHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHH
IAKAYVEAGMYQCVLVIAADKLSSFVNYEDRNTCVLFGDGGSACVVGPSRPGSLKISKVN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEE
LGADGKQGDLLRLPAGGSRCPASQDTIQNQQHFITMEGKEVFKHAVRRMEFAAKTCITEA
CCCCCCCCCEEECCCCCCCCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHC
GLQEEDIDWLVPHQANERIIDAIAKRFAVEDSRVFKTLAKYGNTAASSVGIALDELLRTH
CCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DIHSKERLLLVAFGGGLSWGAVILQQM
CCCCCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MRASIWGTGSYLPKKVLTNADLEKMVETSDEWISTRTGIKERRIASAEEFSSFMGAKAAE
CCCCCCCCCCCCHHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHCCHHHHHHHHCHHHHH
KAIEAAKISKSQIDCIVFATAAPDYIFPSSAALAQAYLGIKEVPAFDCLVACTGFLYGLS
HHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHH
IAKAYVEAGMYQCVLVIAADKLSSFVNYEDRNTCVLFGDGGSACVVGPSRPGSLKISKVN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEE
LGADGKQGDLLRLPAGGSRCPASQDTIQNQQHFITMEGKEVFKHAVRRMEFAAKTCITEA
CCCCCCCCCEEECCCCCCCCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHC
GLQEEDIDWLVPHQANERIIDAIAKRFAVEDSRVFKTLAKYGNTAASSVGIALDELLRTH
CCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DIHSKERLLLVAFGGGLSWGAVILQQM
CCCCCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935