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The map label for this gene is accC

Identifier: 15835019

GI number: 15835019

Start: 460637

End: 462010

Strand: Direct

Name: accC

Synonym: TC0400

Alternate gene names: 15835019

Gene position: 460637-462010 (Clockwise)

Preceding gene: 15835018

Following gene: 15835020

Centisome position: 42.93

GC content: 41.19

Gene sequence:

>1374_bases
ATGAAGAAAGTTTTAATTGCAAATAGAGGCGAAATAGCTGTTCGGATCATTCGGGCATGTCATGATTTGGGATTGTCTAC
TGTTGCCATATATTCTGTAGCAGACCAAGAAGCTCTACATGTGCTTCTAGCTGATGAGGCTGTTTGTATTGGTGAAGCAC
AGGCTGCCAAGTCTTATCTCAAGATCGCAAATATTTTAGCTGCTTGTGAGATTACCGGAGCAGATGCCGTGCATCCTGGT
TATGGCTTTTTAAGCGAAAATGCAAATTTTGCGTCTATTTGTGAAAGTTGTGGGTTAACATTTATTGGCCCTAGTGCGGA
ATCTATAGCAACTATGGGAGATAAAGTTGCTGCTAAGCAGTTGGCAAAAAAAATTAAGTGTCCGGTCATCCCTGGGTCTG
ATGGTGTCGTTAAGGATGAAGTCGAAGGGATAAGAATTGCTGAAAAAATAGGGTTCCCAATTGTTATCAAAGCCGTCGCA
GGAGGCGGAGGGCGAGGGATACGCATCGTTAGAGAAAAAGATGAATTTTATAGGGCTTTTACTGCTGCTCGAGCTGAGGC
TGAATCTGGCTTTAACAATCCCGATGTGTACATTGAAAAATTTATTGAAAACCCAAGGCATTTAGAGGTCCAGGTCATTG
GGGATAAATACGGAAACTATGTGTATCTTGGCGAACGAGATTGTACTGTACAAAGGCGTCGACAAAAATTAATAGAAGAG
ACTCCGAGCCCCATTTTAACCCCTGAAATGAGAGCTAAGGTTGGGAAGGTTGCTGTTGATTTAGCAAGAAGCGCGGGGTA
TTTTTCTGTTGGAACTGTGGAATTTTTATTAGACGCAGAGAAACGATTTTACTTCATGGAAATGAATACCCGTATTCAGG
TGGAACACACTATTACGGAAGAAATAACGGGAATAGACTTGCTAAAAGCACAAATTAGCGTTGCAAAAGGAGAAAAACTT
CCTTGGAAGCAGAAGAATATTGAATTTACAGGACATGTTATTCAATGCCGAATCAATGCCGAAGATCCATGTAATAATTT
TGCTCCATCTCCGGGGCGGTTAGATTACTACCTTCCTCCAGCAGGCCCCTCAGTTCGAGTAGACGGAGCTTGTTATAGTG
GTTACGCGATACCTCCTTACTATGATTCAATGATTGCTAAAGTGATCACAAAAGGGAAAACTCGAGAAGAAGCAATAGCC
ATTATGAAAAGAGCTTTAAAGGAGTTTCATATTGGCGGCGTTCATTCCACGATTCCTTTTCACCAATTTATGTTGGATAA
TCCTAAATTCATCCACTCTGATTACGATATCAATTATGTAGATCGGCTTTTAGCAGAAGGCAGTACTTTTTTGAAGTTAG
CAGAAGGTGACTAA

Upstream 100 bases:

>100_bases
GAAGGCAGGAATGGCTGGTCGTGTAGAGGAGGTATTAATTACCAACGGCGATCCAGTTCAATTTGGTTCTAAGTTATTCC
GTATAGTTAAGGCTTAGTTA

Downstream 100 bases:

>100_bases
TAGATTTTTTAGTTGCCTAGATATTTATAGCCAGTAAAAAAATGCTGTTGTTTTAGAGACAAAAGAGAAGAGATTTTTTT
TGAATTTTTCTTTTCTAAAT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAIYSVADQEALHVLLADEAVCIGEAQAAKSYLKIANILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSAESIATMGDKVAAKQLAKKIKCPVIPGSDGVVKDEVEGIRIAEKIGFPIVIKAVA
GGGGRGIRIVREKDEFYRAFTAARAEAESGFNNPDVYIEKFIENPRHLEVQVIGDKYGNYVYLGERDCTVQRRRQKLIEE
TPSPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDAEKRFYFMEMNTRIQVEHTITEEITGIDLLKAQISVAKGEKL
PWKQKNIEFTGHVIQCRINAEDPCNNFAPSPGRLDYYLPPAGPSVRVDGACYSGYAIPPYYDSMIAKVITKGKTREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFIHSDYDINYVDRLLAEGSTFLKLAEGD

Sequences:

>Translated_457_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAIYSVADQEALHVLLADEAVCIGEAQAAKSYLKIANILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSAESIATMGDKVAAKQLAKKIKCPVIPGSDGVVKDEVEGIRIAEKIGFPIVIKAVA
GGGGRGIRIVREKDEFYRAFTAARAEAESGFNNPDVYIEKFIENPRHLEVQVIGDKYGNYVYLGERDCTVQRRRQKLIEE
TPSPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDAEKRFYFMEMNTRIQVEHTITEEITGIDLLKAQISVAKGEKL
PWKQKNIEFTGHVIQCRINAEDPCNNFAPSPGRLDYYLPPAGPSVRVDGACYSGYAIPPYYDSMIAKVITKGKTREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFIHSDYDINYVDRLLAEGSTFLKLAEGD
>Mature_457_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAIYSVADQEALHVLLADEAVCIGEAQAAKSYLKIANILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSAESIATMGDKVAAKQLAKKIKCPVIPGSDGVVKDEVEGIRIAEKIGFPIVIKAVA
GGGGRGIRIVREKDEFYRAFTAARAEAESGFNNPDVYIEKFIENPRHLEVQVIGDKYGNYVYLGERDCTVQRRRQKLIEE
TPSPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDAEKRFYFMEMNTRIQVEHTITEEITGIDLLKAQISVAKGEKL
PWKQKNIEFTGHVIQCRINAEDPCNNFAPSPGRLDYYLPPAGPSVRVDGACYSGYAIPPYYDSMIAKVITKGKTREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFIHSDYDINYVDRLLAEGSTFLKLAEGD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=49.4407158836689, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=49.4407158836689, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=49.4407158836689, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=449, Percent_Identity=44.988864142539, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.4125560538117, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=31.8181818181818, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=31.8181818181818, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=31.8181818181818, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=31.8181818181818, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=31.8181818181818, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=31.163708086785, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=51.4606741573034, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=46.7561521252796, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=454, Percent_Identity=45.374449339207, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=45.067264573991, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=31.4285714285714, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=26.4705882352941, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=26.4705882352941, Blast_Score=191, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.3087248322148, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.7561521252796, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=41.3636363636364, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=454, Percent_Identity=32.5991189427313, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=31.0810810810811, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=44.6952595936795, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=44.1975308641975, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=31.7365269461078, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=31.7365269461078, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=31.7365269461078, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=31.7365269461078, Blast_Score=243, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50229; Mature: 50229

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLSTVAIYSVADQEALHVLLADEAVCIGEAQAAKSYL
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHEEEEEECCEEEECCHHHHHHHH
KIANILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSAESIATMGDKVAAKQ
HHHHHHHHHEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
LAKKIKCPVIPGSDGVVKDEVEGIRIAEKIGFPIVIKAVAGGGGRGIRIVREKDEFYRAF
HHHHCCCCCCCCCCCCCHHHHCCEEHHHHCCCCEEEEEEECCCCCCEEEEECHHHHHHHH
TAARAEAESGFNNPDVYIEKFIENPRHLEVQVIGDKYGNYVYLGERDCTVQRRRQKLIEE
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDAEKRFYFMEMNTRIQVEHTITE
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECCCEEEEEEECCEEEEEEEHHH
EITGIDLLKAQISVAKGEKLPWKQKNIEFTGHVIQCRINAEDPCNNFAPSPGRLDYYLPP
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCEEEEECC
AGPSVRVDGACYSGYAIPPYYDSMIAKVITKGKTREEAIAIMKRALKEFHIGGVHSTIPF
CCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFIHSDYDINYVDRLLAEGSTFLKLAEGD
HHHHCCCCCEEECCCCHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLSTVAIYSVADQEALHVLLADEAVCIGEAQAAKSYL
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHEEEEEECCEEEECCHHHHHHHH
KIANILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSAESIATMGDKVAAKQ
HHHHHHHHHEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
LAKKIKCPVIPGSDGVVKDEVEGIRIAEKIGFPIVIKAVAGGGGRGIRIVREKDEFYRAF
HHHHCCCCCCCCCCCCCHHHHCCEEHHHHCCCCEEEEEEECCCCCCEEEEECHHHHHHHH
TAARAEAESGFNNPDVYIEKFIENPRHLEVQVIGDKYGNYVYLGERDCTVQRRRQKLIEE
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDAEKRFYFMEMNTRIQVEHTITE
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECCCEEEEEEECCEEEEEEEHHH
EITGIDLLKAQISVAKGEKLPWKQKNIEFTGHVIQCRINAEDPCNNFAPSPGRLDYYLPP
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCEEEEECC
AGPSVRVDGACYSGYAIPPYYDSMIAKVITKGKTREEAIAIMKRALKEFHIGGVHSTIPF
CCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFIHSDYDINYVDRLLAEGSTFLKLAEGD
HHHHCCCCCEEECCCCHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]