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The map label for this gene is accB

Identifier: 15835018

GI number: 15835018

Start: 460142

End: 460633

Strand: Direct

Name: accB

Synonym: TC0399

Alternate gene names: 15835018

Gene position: 460142-460633 (Clockwise)

Preceding gene: 15835017

Following gene: 15835019

Centisome position: 42.89

GC content: 40.65

Gene sequence:

>492_bases
ATGGATTTAAAGCAGATAGAAAAACTCATGATTGCTATGGGCCGCAATAAAATGAAGCGCATAGCGATTAAACGTGACGG
TTTTGAGCTGGAGTTAGAGAGAGACACCGGGCCAAATATTCAAGAACCTGTTTTTTATGATAATCGATTGTTTGCTGGGT
TTACTCAAGAAAGACCTATCCCTTCAGATCAAAATCTTGGTAATCCGATTGTCAAAGAAGTAGGGGAGAAGAAGGAAGAT
AAACCTGTTGAGGGAGATTTTATTGTTTCTCCATTGGTAGGCACTTTTTATGGGGCTCCTTCTCCTGAATCTCCGGCATT
TGTTAAGCCTGGAGATATTGTTTCTGAAGATACGGTTGTTTGTATCGTAGAAGCTATGAAGGTGATGAATGAAGTGAAGG
CAGGAATGGCTGGTCGTGTAGAGGAGGTATTAATTACCAACGGCGATCCAGTTCAATTTGGTTCTAAGTTATTCCGTATA
GTTAAGGCTTAG

Upstream 100 bases:

>100_bases
AGTAGAGGTTTTGGTTCCTCCTTTCGTGGAAATAGGAGATGTTATTAAGGTCGATACGCGTACGTGTGAATATATCCAAC
GCGTCTAAATTGAGGATAAC

Downstream 100 bases:

>100_bases
TTAATGAAGAAAGTTTTAATTGCAAATAGAGGCGAAATAGCTGTTCGGATCATTCGGGCATGTCATGATTTGGGATTGTC
TACTGTTGCCATATATTCTG

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPIPSDQNLGNPIVKEVGEKKED
KPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVVCIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRI
VKA

Sequences:

>Translated_163_residues
MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPIPSDQNLGNPIVKEVGEKKED
KPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVVCIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRI
VKA
>Mature_163_residues
MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPIPSDQNLGNPIVKEVGEKKED
KPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVVCIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRI
VKA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Escherichia coli, GI1789653, Length=160, Percent_Identity=30.625, Blast_Score=80, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCP_CHLMU (Q9PKR5)

Other databases:

- EMBL:   AE002160
- PIR:   C81708
- RefSeq:   NP_296777.1
- ProteinModelPortal:   Q9PKR5
- SMR:   Q9PKR5
- GeneID:   1245751
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0399
- TIGR:   TC_0399
- HOGENOM:   HBG745267
- OMA:   MSGRVVE
- ProtClustDB:   PRK06302
- BioCyc:   CMUR243161:TC_0399-MONOMER
- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053
- PRINTS:   PR01071
- TIGRFAMs:   TIGR00531

Pfam domain/function: PF00364 Biotin_lipoyl; SSF51230 Hybrid_motif

EC number: NA

Molecular weight: Translated: 18084; Mature: 18084

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPI
CCHHHHHHHHHHHCCCHHHHEEEECCCEEEEEECCCCCCCCCCEEECCEEEECCCCCCCC
PSDQNLGNPIVKEVGEKKEDKPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVV
CCCCCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHH
CIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRIVKA
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDLKQIEKLMIAMGRNKMKRIAIKRDGFELELERDTGPNIQEPVFYDNRLFAGFTQERPI
CCHHHHHHHHHHHCCCHHHHEEEECCCEEEEEECCCCCCCCCCEEECCEEEECCCCCCCC
PSDQNLGNPIVKEVGEKKEDKPVEGDFIVSPLVGTFYGAPSPESPAFVKPGDIVSEDTVV
CCCCCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHH
CIVEAMKVMNEVKAGMAGRVEEVLITNGDPVQFGSKLFRIVKA
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935