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The map label for this gene is nth

Identifier: 15834694

GI number: 15834694

Start: 79650

End: 80282

Strand: Reverse

Name: nth

Synonym: TC0069

Alternate gene names: 15834694

Gene position: 80282-79650 (Counterclockwise)

Preceding gene: 15834695

Following gene: 15834687

Centisome position: 7.48

GC content: 42.34

Gene sequence:

>633_bases
ATGAACAAGCTACGCGTACCATCCAAGCGAGCATTTATCTTAAACACCTTGAACCAACTGTTCCCCAATCCTGAACCTTC
TTTAAAAGGATGGCATTCTCCTTTCCAGCTTCTTATCGCCATTCTTTTATCTGGGAACTCCACGGACAAAGTTGTCAATA
CTGTTATACCGGCTCTCTTTGCTAAAGCTCCTGATGCGCAATCCATGAGTAAACTTCCTCTTTCTGAAATATATTCGCTC
ATTGCTCCTTGTGGATTGGGAGAACGCAAATCCGTTTACATCCATGAACTGTCTTGTATTCTTGTAGAGCGTTATGCTCA
GGAGCCTCCTCGCTCCCTTTCGGAGCTGACCAAGCTTCCCGGAGTAGGAAGAAAAACCGCCTCAGTTTTTTTAAGCATCT
ACTATGGAGAGAATACTTTCCCTGTAGATACGCATATTCTTCGCCTAGCTCATCGTTGGAAACTTTCTACAAAACGTAGC
CCTTCTGCAGCAGAGAAAGATTTAGTCGCATTCTTTGGGAAGACGAATTCACCGAAATTACATCTACAACTTATCTACTA
TGCAAGAGAGTATTGTCCGGCCCTACATCACAAAATAGATGCTTGTCCTATTTGTTCTTTCTTAAATTCTTAA

Upstream 100 bases:

>100_bases
AGACAAGCTTTACATTCTATAGGGAATCTATCTGGATCTGAAGTCACTGAAAATGTTTTAGGAGAAATTTTCAGTAAATT
TTGTATAGGGAAATAGCCGG

Downstream 100 bases:

>100_bases
ACAGACTAACGAGCCTCTCTATGGAAAGTCCCATCCCCTGATTCTGAAGGAATCATTTGCCAAAAAGGAGGTCGAGGGGG
ACAGCGAAGAATCTCTTCTT

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNKLRVPSKRAFILNTLNQLFPNPEPSLKGWHSPFQLLIAILLSGNSTDKVVNTVIPALFAKAPDAQSMSKLPLSEIYSL
IAPCGLGERKSVYIHELSCILVERYAQEPPRSLSELTKLPGVGRKTASVFLSIYYGENTFPVDTHILRLAHRWKLSTKRS
PSAAEKDLVAFFGKTNSPKLHLQLIYYAREYCPALHHKIDACPICSFLNS

Sequences:

>Translated_210_residues
MNKLRVPSKRAFILNTLNQLFPNPEPSLKGWHSPFQLLIAILLSGNSTDKVVNTVIPALFAKAPDAQSMSKLPLSEIYSL
IAPCGLGERKSVYIHELSCILVERYAQEPPRSLSELTKLPGVGRKTASVFLSIYYGENTFPVDTHILRLAHRWKLSTKRS
PSAAEKDLVAFFGKTNSPKLHLQLIYYAREYCPALHHKIDACPICSFLNS
>Mature_210_residues
MNKLRVPSKRAFILNTLNQLFPNPEPSLKGWHSPFQLLIAILLSGNSTDKVVNTVIPALFAKAPDAQSMSKLPLSEIYSL
IAPCGLGERKSVYIHELSCILVERYAQEPPRSLSELTKLPGVGRKTASVFLSIYYGENTFPVDTHILRLAHRWKLSTKRS
PSAAEKDLVAFFGKTNSPKLHLQLIYYAREYCPALHHKIDACPICSFLNS

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=171, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1787920, Length=204, Percent_Identity=34.3137254901961, Blast_Score=101, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17554540, Length=174, Percent_Identity=27.0114942528736, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550361, Length=119, Percent_Identity=27.7310924369748, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 23505; Mature: 23505

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLRVPSKRAFILNTLNQLFPNPEPSLKGWHSPFQLLIAILLSGNSTDKVVNTVIPALF
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
AKAPDAQSMSKLPLSEIYSLIAPCGLGERKSVYIHELSCILVERYAQEPPRSLSELTKLP
HCCCCHHHHHCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHCC
GVGRKTASVFLSIYYGENTFPVDTHILRLAHRWKLSTKRSPSAAEKDLVAFFGKTNSPKL
CCCCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEE
HLQLIYYAREYCPALHHKIDACPICSFLNS
EEHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MNKLRVPSKRAFILNTLNQLFPNPEPSLKGWHSPFQLLIAILLSGNSTDKVVNTVIPALF
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
AKAPDAQSMSKLPLSEIYSLIAPCGLGERKSVYIHELSCILVERYAQEPPRSLSELTKLP
HCCCCHHHHHCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHCC
GVGRKTASVFLSIYYGENTFPVDTHILRLAHRWKLSTKRSPSAAEKDLVAFFGKTNSPKL
CCCCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEE
HLQLIYYAREYCPALHHKIDACPICSFLNS
EEHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704260; 8760912; 9384377 [H]