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The map label for this gene is pyrH

Identifier: 15834674

GI number: 15834674

Start: 55827

End: 56564

Strand: Reverse

Name: pyrH

Synonym: TC0049

Alternate gene names: 15834674

Gene position: 56564-55827 (Counterclockwise)

Preceding gene: 15834675

Following gene: 15834673

Centisome position: 5.27

GC content: 44.31

Gene sequence:

>738_bases
ATGATGAAAAAACGAGTGAAACGAGTTTTATTCAAGATCTCTGGAGAGGCTCTTTCTGACGCTAGTTCTAGCGACAAAAT
CAGTGAAGAACGCCTCTCTCGATTGATTGCAGAACTTAAGGTTGTTCGCAATGCGGATGTTGAAGTTGCGGTGGTAATCG
GTGGAGGGAATATCCTTCGAGGGCTATCACAGAGCCAAAACCTGCAGATCAATCGGGTTTCAGCTGATCAAATGGGAATG
TTAGCGACGTTGATTAATGGGATGGCATTAGCGGATGCTTTAAAGACCGAGGATGTGCCTAATCTATTAACATCGACTTT
ATCTTGCCCACAGTTGGCAGAGTTGTATAACCCGCAAAAGGCATCTGACGCTCTCAGTCAAGGCAAGGTTGTTATATGTA
CTATGGGAGCAGGAGCTCCGTACTTGACAACTGACACTGGTGCAGCTTTGCGTGCTTGTGAATTGAAAGTTGATGTTTTG
CTTAAAGCTACCATGCATGTGGATGGTGTTTACGATCGAGATCCTCGAGAGTTTGCTGATGCGGTAAGGTATGACCACAT
CTCTTATAGAGATTTTCTCTCCCAAGGGTTGGGCGCGATTGATCCTTCTGCAGTGTCTTTATGTATGGAAGCAGGAATCC
CAATTAGAATGTTTAGCTTCACCAAACATTCCTTGGAAGAAGCCATTTTTAATACCGTTGGTACAGTGATATCTTCTACA
GAGGGAGGACAACTATGA

Upstream 100 bases:

>100_bases
TCAGGAATTGGTTGATAGAGCTGCAAAAGCTAGTGGAGAGCCGCTAAAAGTTGAGCACTTTGTCTTTTGGAAGATAGGCG
CATAAAAACCAAGTGGCGAG

Downstream 100 bases:

>100_bases
CACTTACTTCTGCGGAAAAAGAGATGTCTGGCGTTTTAACGTTTTTCCAAAAAGAAATTCGTGGTTTCAGAACTGGGAAA
GCACATCCGGCATTGGTAGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MMKKRVKRVLFKISGEALSDASSSDKISEERLSRLIAELKVVRNADVEVAVVIGGGNILRGLSQSQNLQINRVSADQMGM
LATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQKASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVL
LKATMHVDGVYDRDPREFADAVRYDHISYRDFLSQGLGAIDPSAVSLCMEAGIPIRMFSFTKHSLEEAIFNTVGTVISST
EGGQL

Sequences:

>Translated_245_residues
MMKKRVKRVLFKISGEALSDASSSDKISEERLSRLIAELKVVRNADVEVAVVIGGGNILRGLSQSQNLQINRVSADQMGM
LATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQKASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVL
LKATMHVDGVYDRDPREFADAVRYDHISYRDFLSQGLGAIDPSAVSLCMEAGIPIRMFSFTKHSLEEAIFNTVGTVISST
EGGQL
>Mature_245_residues
MMKKRVKRVLFKISGEALSDASSSDKISEERLSRLIAELKVVRNADVEVAVVIGGGNILRGLSQSQNLQINRVSADQMGM
LATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQKASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVL
LKATMHVDGVYDRDPREFADAVRYDHISYRDFLSQGLGAIDPSAVSLCMEAGIPIRMFSFTKHSLEEAIFNTVGTVISST
EGGQL

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=220, Percent_Identity=38.6363636363636, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHLMU (P71147)

Other databases:

- EMBL:   U60196
- EMBL:   AE002160
- PIR:   H81746
- RefSeq:   NP_296433.1
- ProteinModelPortal:   P71147
- SMR:   P71147
- GeneID:   1245577
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0049
- TIGR:   TC_0049
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CMUR243161:TC_0049-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26326; Mature: 26326

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 76-76 BINDING 164-164 BINDING 171-171 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKRVKRVLFKISGEALSDASSSDKISEERLSRLIAELKVVRNADVEVAVVIGGGNILR
CCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
GLSQSQNLQINRVSADQMGMLATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCH
ASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVLLKATMHVDGVYDRDPREFAD
HHHHHHCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AVRYDHISYRDFLSQGLGAIDPSAVSLCMEAGIPIRMFSFTKHSLEEAIFNTVGTVISST
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
EGGQL
CCCCC
>Mature Secondary Structure
MMKKRVKRVLFKISGEALSDASSSDKISEERLSRLIAELKVVRNADVEVAVVIGGGNILR
CCHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHH
GLSQSQNLQINRVSADQMGMLATLINGMALADALKTEDVPNLLTSTLSCPQLAELYNPQK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCH
ASDALSQGKVVICTMGAGAPYLTTDTGAALRACELKVDVLLKATMHVDGVYDRDPREFAD
HHHHHHCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AVRYDHISYRDFLSQGLGAIDPSAVSLCMEAGIPIRMFSFTKHSLEEAIFNTVGTVISST
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
EGGQL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9244380; 10684935