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The map label for this gene is frr

Identifier: 15834673

GI number: 15834673

Start: 55291

End: 55830

Strand: Reverse

Name: frr

Synonym: TC0048

Alternate gene names: 15834673

Gene position: 55830-55291 (Counterclockwise)

Preceding gene: 15834674

Following gene: 15834672

Centisome position: 5.2

GC content: 40.19

Gene sequence:

>540_bases
ATGACACTTACTTCTGCGGAAAAAGAGATGTCTGGCGTTTTAACGTTTTTCCAAAAAGAAATTCGTGGTTTCAGAACTGG
GAAAGCACATCCGGCATTGGTAGAGACTGTTACTGTTGAAGTATACGGAACAACCATGCGGTTGTCAGATATTGCATCAA
TCAGTGTTTCTGATACGCGACAGCTTCTAATCTCCCCTTATGATGCAGGGAACGTTTCTGCTATTTCTAAAGGGATTTTG
GCAGCCAATTTAAACCTTCAGCCTATAGTTGAAGGAGCTACGGTTCGAATTAATGTACCTGAGCCTACAGAAGAATACAG
ACGCGAAGTAATCAAGCAATTGAAACGTAAGAGCGAGGAAGCTAAGGTTTCCATTCGTAATATTCGACGTACTTGTAATG
ATAGGTTGAAAAAAGACGATAGTCTAACAGAAGATGCTGTGAAAGGCTTGGAGAAAAAAATTCAAGAGCTCACAGATAAG
TTTTGCAAGCAGATAGAAGAGCTCGCAAAACAAAAAGAAGCTGAATTGTCTTCGATATAG

Upstream 100 bases:

>100_bases
GAATCCCAATTAGAATGTTTAGCTTCACCAAACATTCCTTGGAAGAAGCCATTTTTAATACCGTTGGTACAGTGATATCT
TCTACAGAGGGAGGACAACT

Downstream 100 bases:

>100_bases
ACAGCTTCTTTGCAATCGGACTTTTCTTTGAAAATAAATGAGTTAGAAGAAAAAGAAGATTGCAGAAAAAAGGGGTTTAA
TAGTAATATTAAGCCCGTCC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVYGTTMRLSDIASISVSDTRQLLISPYDAGNVSAISKGIL
AANLNLQPIVEGATVRINVPEPTEEYRREVIKQLKRKSEEAKVSIRNIRRTCNDRLKKDDSLTEDAVKGLEKKIQELTDK
FCKQIEELAKQKEAELSSI

Sequences:

>Translated_179_residues
MTLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVYGTTMRLSDIASISVSDTRQLLISPYDAGNVSAISKGIL
AANLNLQPIVEGATVRINVPEPTEEYRREVIKQLKRKSEEAKVSIRNIRRTCNDRLKKDDSLTEDAVKGLEKKIQELTDK
FCKQIEELAKQKEAELSSI
>Mature_178_residues
TLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVYGTTMRLSDIASISVSDTRQLLISPYDAGNVSAISKGILA
ANLNLQPIVEGATVRINVPEPTEEYRREVIKQLKRKSEEAKVSIRNIRRTCNDRLKKDDSLTEDAVKGLEKKIQELTDKF
CKQIEELAKQKEAELSSI

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI291042689, Length=158, Percent_Identity=29.746835443038, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI20270317, Length=178, Percent_Identity=25.2808988764045, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786368, Length=174, Percent_Identity=37.9310344827586, Blast_Score=124, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321827, Length=179, Percent_Identity=29.0502793296089, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_CHLMU (P71148)

Other databases:

- EMBL:   U60196
- EMBL:   AE002160
- PIR:   G81746
- RefSeq:   NP_296432.1
- ProteinModelPortal:   P71148
- SMR:   P71148
- GeneID:   1245576
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0048
- TIGR:   TC_0048
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   P71148
- ProtClustDB:   PRK00083
- BioCyc:   CMUR243161:TC_0048-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20026; Mature: 19895

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVYGTTMRLSDIASISVSDTR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEECCEEEHHHHHHCCHHHHH
QLLISPYDAGNVSAISKGILAANLNLQPIVEGATVRINVPEPTEEYRREVIKQLKRKSEE
HHHCCCCCCCCHHHHHHCHHEECCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCHH
AKVSIRNIRRTCNDRLKKDDSLTEDAVKGLEKKIQELTDKFCKQIEELAKQKEAELSSI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLTSAEKEMSGVLTFFQKEIRGFRTGKAHPALVETVTVEVYGTTMRLSDIASISVSDTR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEECCEEEHHHHHHCCHHHHH
QLLISPYDAGNVSAISKGILAANLNLQPIVEGATVRINVPEPTEEYRREVIKQLKRKSEE
HHHCCCCCCCCHHHHHHCHHEECCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCHH
AKVSIRNIRRTCNDRLKKDDSLTEDAVKGLEKKIQELTDKFCKQIEELAKQKEAELSSI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9244380; 10684935