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The map label for this gene is cobD [H]

Identifier: 158338986

GI number: 158338986

Start: 5965747

End: 5966850

Strand: Reverse

Name: cobD [H]

Synonym: AM1_5905

Alternate gene names: 158338986

Gene position: 5966850-5965747 (Counterclockwise)

Preceding gene: 158338987

Following gene: 158338985

Centisome position: 91.75

GC content: 49.18

Gene sequence:

>1104_bases
TTGAGTCGCCCTTTACATGGAGGCAACCTGCGGTGGGCTGCAGACATAGCAGGTTGTTCTCCCAACTGTATCCTTGATTT
TTCGGCAAGTATCAACCCACTTGGGCCGCCTGAATCAGCGATTTCAGCCATTCAAACTCATCTCGATACCCTCACGGCTT
ATCCAGATCCTAGTTATCAGTCAATATGCCAGGTGTTGAGTGAGGTTCATCAACTCCCCGTTGACTGGTTTTTGCCGGGA
AATGGTTCAGCTGAATTACTCACTTGGGCCTGCCGTGATTTGGCCCAATTGGCATGGACTGGGGTTCTAAAGCCTGCCTT
TGCTGACTATCAACGGGCACTGAAGGCGTTTCAAGCTCAAATTCGGCCATTACCTTTGAATCTTAGACAGATTCAACATC
AATCTTCCAGTGAGTTGATCGAGCAGGCATTACAGATCGCTCGTCAGTCTGCCGATTCAGCTCAAGCTGGGCTATTACTG
AATAACCCCCACAATCCCACTGGGGGGCTAATCAGCATCCATCAAATCGAACCGTTTCTAGAGCAGTTCCCTTTGGTGGT
AGTGGATGAAGCATTTATGGACTTTCTGCCTGTAGATGCTGACTACAGCTTGATCTCTAAAGTGCAAGATTTTCCAAATC
TCGTGATCTTGCGTTCCCTGACCAAATTTTATAGTTTGCCTGGGTTGCGGTTGGGGTATGCCATTGGTCACCCCGATCAA
CTACGGCCCTGGCAGCAATGCCGTGATCCCTGGTCTGTAAACTCTCTGGCCGTTATGGCGGGGATAGCGGTGCTGGGAGA
TCGCGCTTTTCAGAACAAAACTCTATCTTGGTTGCCCCCTGTCCGTACCGAACTGATGCAAGGTTTGGTGGCGTTGGGGG
CTTATCCCCTGGAGGGGGCAGCGAATTTTCTTTTAGTACAAACGAAGGTTTCAGTCCCTTTGCTGCAGGAGCTGCTTTTA
AAGCATCATCGGATTCTCATTCGAGATTGTCTTAGCTTTCCCGAATTAGGAGATCAGTATTTTCGGATTGCGGTACGAAC
CCAAGCAGACAATCAACGGTTACTGACTGCTTTGGCCGATTGCCTACCTCGGTTATCTGTTTAG

Upstream 100 bases:

>100_bases
TCCCGCAACTAAAGTTCCAGCTTTCTCTGCAGGTAAGCTATTTAAGGAAAAAGTTGCTCCTAAAAAGTAATTCCTTAATT
TTCTGGATGAGGCGTCACTA

Downstream 100 bases:

>100_bases
ATGAGAGAGGCATAAACGCCTGGGGAGTAGACAATGGCTGATTATGATTTGGTGGTGGTGGGTAATAATGCGGTGGCTCC
CTGGGCTGCGATCGCAGCCA

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSRPLHGGNLRWAADIAGCSPNCILDFSASINPLGPPESAISAIQTHLDTLTAYPDPSYQSICQVLSEVHQLPVDWFLPG
NGSAELLTWACRDLAQLAWTGVLKPAFADYQRALKAFQAQIRPLPLNLRQIQHQSSSELIEQALQIARQSADSAQAGLLL
NNPHNPTGGLISIHQIEPFLEQFPLVVVDEAFMDFLPVDADYSLISKVQDFPNLVILRSLTKFYSLPGLRLGYAIGHPDQ
LRPWQQCRDPWSVNSLAVMAGIAVLGDRAFQNKTLSWLPPVRTELMQGLVALGAYPLEGAANFLLVQTKVSVPLLQELLL
KHHRILIRDCLSFPELGDQYFRIAVRTQADNQRLLTALADCLPRLSV

Sequences:

>Translated_367_residues
MSRPLHGGNLRWAADIAGCSPNCILDFSASINPLGPPESAISAIQTHLDTLTAYPDPSYQSICQVLSEVHQLPVDWFLPG
NGSAELLTWACRDLAQLAWTGVLKPAFADYQRALKAFQAQIRPLPLNLRQIQHQSSSELIEQALQIARQSADSAQAGLLL
NNPHNPTGGLISIHQIEPFLEQFPLVVVDEAFMDFLPVDADYSLISKVQDFPNLVILRSLTKFYSLPGLRLGYAIGHPDQ
LRPWQQCRDPWSVNSLAVMAGIAVLGDRAFQNKTLSWLPPVRTELMQGLVALGAYPLEGAANFLLVQTKVSVPLLQELLL
KHHRILIRDCLSFPELGDQYFRIAVRTQADNQRLLTALADCLPRLSV
>Mature_366_residues
SRPLHGGNLRWAADIAGCSPNCILDFSASINPLGPPESAISAIQTHLDTLTAYPDPSYQSICQVLSEVHQLPVDWFLPGN
GSAELLTWACRDLAQLAWTGVLKPAFADYQRALKAFQAQIRPLPLNLRQIQHQSSSELIEQALQIARQSADSAQAGLLLN
NPHNPTGGLISIHQIEPFLEQFPLVVVDEAFMDFLPVDADYSLISKVQDFPNLVILRSLTKFYSLPGLRLGYAIGHPDQL
RPWQQCRDPWSVNSLAVMAGIAVLGDRAFQNKTLSWLPPVRTELMQGLVALGAYPLEGAANFLLVQTKVSVPLLQELLLK
HHRILIRDCLSFPELGDQYFRIAVRTQADNQRLLTALADCLPRLSV

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=368, Percent_Identity=25.2717391304348, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40604; Mature: 40473

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPLHGGNLRWAADIAGCSPNCILDFSASINPLGPPESAISAIQTHLDTLTAYPDPSYQ
CCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
SICQVLSEVHQLPVDWFLPGNGSAELLTWACRDLAQLAWTGVLKPAFADYQRALKAFQAQ
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRPLPLNLRQIQHQSSSELIEQALQIARQSADSAQAGLLLNNPHNPTGGLISIHQIEPFL
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCEEECCCCCCCCCEEEHHHHHHHH
EQFPLVVVDEAFMDFLPVDADYSLISKVQDFPNLVILRSLTKFYSLPGLRLGYAIGHPDQ
HHCCCCEEHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCC
LRPWQQCRDPWSVNSLAVMAGIAVLGDRAFQNKTLSWLPPVRTELMQGLVALGAYPLEGA
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
ANFLLVQTKVSVPLLQELLLKHHRILIRDCLSFPELGDQYFRIAVRTQADNQRLLTALAD
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHEEEEEEECCCHHHHHHHHHH
CLPRLSV
HHHCCCC
>Mature Secondary Structure 
SRPLHGGNLRWAADIAGCSPNCILDFSASINPLGPPESAISAIQTHLDTLTAYPDPSYQ
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
SICQVLSEVHQLPVDWFLPGNGSAELLTWACRDLAQLAWTGVLKPAFADYQRALKAFQAQ
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRPLPLNLRQIQHQSSSELIEQALQIARQSADSAQAGLLLNNPHNPTGGLISIHQIEPFL
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCEEECCCCCCCCCEEEHHHHHHHH
EQFPLVVVDEAFMDFLPVDADYSLISKVQDFPNLVILRSLTKFYSLPGLRLGYAIGHPDQ
HHCCCCEEHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCC
LRPWQQCRDPWSVNSLAVMAGIAVLGDRAFQNKTLSWLPPVRTELMQGLVALGAYPLEGA
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
ANFLLVQTKVSVPLLQELLLKHHRILIRDCLSFPELGDQYFRIAVRTQADNQRLLTALAD
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHEEEEEEECCCHHHHHHHHHH
CLPRLSV
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]