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The map label for this gene is merA [H]

Identifier: 158338985

GI number: 158338985

Start: 5964427

End: 5965713

Strand: Reverse

Name: merA [H]

Synonym: AM1_5904

Alternate gene names: 158338985

Gene position: 5965713-5964427 (Counterclockwise)

Preceding gene: 158338986

Following gene: 158338983

Centisome position: 91.73

GC content: 52.6

Gene sequence:

>1287_bases
ATGGCTGATTATGATTTGGTGGTGGTGGGTAATAATGCGGTGGCTCCCTGGGCTGCGATCGCAGCCAAAGAACAGTCGGC
CCGAGTGGCATTTATTGCTGTTGCGCCAGCCCCCATCCCGTATCATTTGCTGTTGCGACAGTGGGTACAGACCCAGCCGT
CTATGGCTTTGGCCGAATGGGTTAAGGCCATGGCCTCGCGGGTACAGGCACCTTATTCGCCAGCCAAATTAGCCAGTTTG
GGCATTGAACAGATCGATGGTATCGCTCAATTTAAAACCAAACCGCAATTTCAGGTGCATTGTCAGAATCGGGTATTGCT
GGCCCACCGGTATCTTCTCTGTTTAGATGCCGATTTATCTGCACCAGATGTTCCCGGTTCAGCGGACTGGCTTAGTCCAG
CAGATGTCCTTACCCGACTAGAAAATCTTCATCAACCGTTAGCCGATCCAGTGCTGGTGGTGGGGGATGGTCCGGTGGCC
GTTTCCCTGAGCCAATCCTTAGGGCGATTGGGGCATTCTGTTCACTTACTTTGTCCCCTGAACCAAATTTTGCCTGGGGA
AGATGCTGAAGCGGCTTGGCGAGTGCAAGCCCACCTAGAGGCCGATCATGTCAATATTCACACCCACAGCCAGATCAAAG
ACGTTACTCCATCATCCAGCTCCTATCAGGTAACAACAAATCAAGGCAAATTGATGGCCGGATCCTTAGTTTGGGCCGTA
GAAACAACGTCAGCCATCATCAATCCCAATCAAATTGCTGTGGATCTTCGCCATACCGCTCAAGGTTTGTGGGTGAACCC
GCGATTGCAAACCTCATGCTCCCAAGTGTATGCCTGCGGGTCTGTGCTAGGAGGATATACCCTGGCAGATATTGCTCGGC
ATGAGGCCGGGGTAGCGGTAAATAATGCCTTGGGGGCTAGGCAGGCGATTAAATATGGCATCCTACCCTGGACTATCCCG
ACCATGCCAGAGCTAGCCAGAGTGGGGTTAACAGAGACTCTGGTCCAAGAAGCATCCATCCCCTTTCGGTGTTTTTATCA
CACCTATCAACAGTCAGACAAAGGCCAACTCCAGGAGCAGACGGGTTGGTGTAAGGTCCTTGTCCACAAGAACGGACAAA
TACTGGGGGCTCATATGGTGGGTATTGGGGCAGCCGAAGTGGTTCATCTGATCGCTTTAGCGATGCAAAAGCGGTGCCCC
GTGTCAGAGCTAGCTGGACTGGGTACGTTTAGTTCCAGCTACGGCAGCCTTGTCGGGCAAATCGCTCGGCAGTGGTGCCA
AAAGTAA

Upstream 100 bases:

>100_bases
AACCCAAGCAGACAATCAACGGTTACTGACTGCTTTGGCCGATTGCCTACCTCGGTTATCTGTTTAGATGAGAGAGGCAT
AAACGCCTGGGGAGTAGACA

Downstream 100 bases:

>100_bases
CTTCAGCCAAGGCCGTTTTCAAGGGAATGCTGTATCTTCTACACCGCTTGAGGCGCTTTGCCTATCTGTTCACGGCCATG
GGGGTCAGTCAAGCTGGTTA

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MADYDLVVVGNNAVAPWAAIAAKEQSARVAFIAVAPAPIPYHLLLRQWVQTQPSMALAEWVKAMASRVQAPYSPAKLASL
GIEQIDGIAQFKTKPQFQVHCQNRVLLAHRYLLCLDADLSAPDVPGSADWLSPADVLTRLENLHQPLADPVLVVGDGPVA
VSLSQSLGRLGHSVHLLCPLNQILPGEDAEAAWRVQAHLEADHVNIHTHSQIKDVTPSSSSYQVTTNQGKLMAGSLVWAV
ETTSAIINPNQIAVDLRHTAQGLWVNPRLQTSCSQVYACGSVLGGYTLADIARHEAGVAVNNALGARQAIKYGILPWTIP
TMPELARVGLTETLVQEASIPFRCFYHTYQQSDKGQLQEQTGWCKVLVHKNGQILGAHMVGIGAAEVVHLIALAMQKRCP
VSELAGLGTFSSSYGSLVGQIARQWCQK

Sequences:

>Translated_428_residues
MADYDLVVVGNNAVAPWAAIAAKEQSARVAFIAVAPAPIPYHLLLRQWVQTQPSMALAEWVKAMASRVQAPYSPAKLASL
GIEQIDGIAQFKTKPQFQVHCQNRVLLAHRYLLCLDADLSAPDVPGSADWLSPADVLTRLENLHQPLADPVLVVGDGPVA
VSLSQSLGRLGHSVHLLCPLNQILPGEDAEAAWRVQAHLEADHVNIHTHSQIKDVTPSSSSYQVTTNQGKLMAGSLVWAV
ETTSAIINPNQIAVDLRHTAQGLWVNPRLQTSCSQVYACGSVLGGYTLADIARHEAGVAVNNALGARQAIKYGILPWTIP
TMPELARVGLTETLVQEASIPFRCFYHTYQQSDKGQLQEQTGWCKVLVHKNGQILGAHMVGIGAAEVVHLIALAMQKRCP
VSELAGLGTFSSSYGSLVGQIARQWCQK
>Mature_427_residues
ADYDLVVVGNNAVAPWAAIAAKEQSARVAFIAVAPAPIPYHLLLRQWVQTQPSMALAEWVKAMASRVQAPYSPAKLASLG
IEQIDGIAQFKTKPQFQVHCQNRVLLAHRYLLCLDADLSAPDVPGSADWLSPADVLTRLENLHQPLADPVLVVGDGPVAV
SLSQSLGRLGHSVHLLCPLNQILPGEDAEAAWRVQAHLEADHVNIHTHSQIKDVTPSSSSYQVTTNQGKLMAGSLVWAVE
TTSAIINPNQIAVDLRHTAQGLWVNPRLQTSCSQVYACGSVLGGYTLADIARHEAGVAVNNALGARQAIKYGILPWTIPT
MPELARVGLTETLVQEASIPFRCFYHTYQQSDKGQLQEQTGWCKVLVHKNGQILGAHMVGIGAAEVVHLIALAMQKRCPV
SELAGLGTFSSSYGSLVGQIARQWCQK

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=272, Percent_Identity=24.6323529411765, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI87082354, Length=440, Percent_Identity=25.2272727272727, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081717, Length=334, Percent_Identity=23.9520958083832, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=266, Percent_Identity=23.6842105263158, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 46185; Mature: 46053

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADYDLVVVGNNAVAPWAAIAAKEQSARVAFIAVAPAPIPYHLLLRQWVQTQPSMALAEW
CCCCEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHH
VKAMASRVQAPYSPAKLASLGIEQIDGIAQFKTKPQFQVHCQNRVLLAHRYLLCLDADLS
HHHHHHHHCCCCCHHHHHHHCHHHHCCHHHHCCCCCEEEEECCEEEEEEEEEEEEECCCC
APDVPGSADWLSPADVLTRLENLHQPLADPVLVVGDGPVAVSLSQSLGRLGHSVHLLCPL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHCCCCEEEEECH
NQILPGEDAEAAWRVQAHLEADHVNIHTHSQIKDVTPSSSSYQVTTNQGKLMAGSLVWAV
HHHCCCCCCCCEEEEEEEEEECEEEEEECCHHCCCCCCCCCEEEECCCCCEEECEEEEEE
ETTSAIINPNQIAVDLRHTAQGLWVNPRLQTSCSQVYACGSVLGGYTLADIARHEAGVAV
ECCCEEECCCCEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEE
NNALGARQAIKYGILPWTIPTMPELARVGLTETLVQEASIPFRCFYHTYQQSDKGQLQEQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEHHHHCCCCCCCHHHC
TGWCKVLVHKNGQILGAHMVGIGAAEVVHLIALAMQKRCPVSELAGLGTFSSSYGSLVGQ
CCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
IARQWCQK
HHHHHHCC
>Mature Secondary Structure 
ADYDLVVVGNNAVAPWAAIAAKEQSARVAFIAVAPAPIPYHLLLRQWVQTQPSMALAEW
CCCEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHH
VKAMASRVQAPYSPAKLASLGIEQIDGIAQFKTKPQFQVHCQNRVLLAHRYLLCLDADLS
HHHHHHHHCCCCCHHHHHHHCHHHHCCHHHHCCCCCEEEEECCEEEEEEEEEEEEECCCC
APDVPGSADWLSPADVLTRLENLHQPLADPVLVVGDGPVAVSLSQSLGRLGHSVHLLCPL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHCCCCEEEEECH
NQILPGEDAEAAWRVQAHLEADHVNIHTHSQIKDVTPSSSSYQVTTNQGKLMAGSLVWAV
HHHCCCCCCCCEEEEEEEEEECEEEEEECCHHCCCCCCCCCEEEECCCCCEEECEEEEEE
ETTSAIINPNQIAVDLRHTAQGLWVNPRLQTSCSQVYACGSVLGGYTLADIARHEAGVAV
ECCCEEECCCCEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEE
NNALGARQAIKYGILPWTIPTMPELARVGLTETLVQEASIPFRCFYHTYQQSDKGQLQEQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEHHHHCCCCCCCHHHC
TGWCKVLVHKNGQILGAHMVGIGAAEVVHLIALAMQKRCPVSELAGLGTFSSSYGSLVGQ
CCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
IARQWCQK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]