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The map label for this gene is phoP [H]

Identifier: 158338202

GI number: 158338202

Start: 5150711

End: 5151460

Strand: Direct

Name: phoP [H]

Synonym: AM1_5096

Alternate gene names: 158338202

Gene position: 5150711-5151460 (Clockwise)

Preceding gene: 158338201

Following gene: 158338204

Centisome position: 79.2

GC content: 46.27

Gene sequence:

>750_bases
TTGGGTAGGCAACATAAAATTTTGATTGTTGACGACGAAGCAACGATTCGTCGGATTTTGGCGACCCGTCTATCGATGGT
TGGATATGAAATTGTGGTTGCTGCTGATGGGGTAGAGGCACTTGAGCAATTTGAAGCTGAAAAACCTGATTTGATTGTGT
TAGATGTGATGATGCCCCGCATGAATGGGCTGCAGGTTTGTCAGACCTTACGAGAATCAACGGGTGTTCCTATTATTATG
CTGACGGCTCTAGGAGAAGTGAGCGATCGCATTAAGGGATTGGAATTAGGGGCAGATGACTATTTACCCAAGCCTTTTTC
TCCTAAGGAGTTAGAAAGCAGAATTCAGGCTATTTTACGGCGAACCGTTCCTGGTAAAGGCAAAGCAGGAGCGGGCCACG
CTGCAGAGCAGGTCATTATGGAAATTGGGCCGTTGCGGATTGAAACCCATAAGCGACAGGTTTACTTGCATGGCCAAAGA
ATTCAACTGACTGGCATCGAATTTGATGTCCTCAAGCTATTAGTCTCCAAGGCTGGTCAGACCGTCTCCCGCTCCGATAT
TTTGCAGCAAGTATGGGGATACTCTGCTAACCACTATGCCGATTTGCGAGTGGTCGATGTGAATGTCTCCCGGCTTCGTT
CCAAGATTGGCGATAGCTCCAAACAACCCGAGTACATTCATACGGACTGGGGGATTGGCTATTTTTTTCAAAAAATGAGA
AAAAAATCTCCTGAACAAGTGATGTGTTAG

Upstream 100 bases:

>100_bases
GTCAGCATGGACTGAAGCAACTCCTATGGATGTTGTAAGGGTGTCGTTCGTTTTTGCGCTTATCAACTTGTTTTTAAAAT
AGTCTGGAGATTTAGGTCCC

Downstream 100 bases:

>100_bases
AAGGATTTGATATCCTGTTTTTCTGTCGTACCGAGTAGGGTGTGATGGACTTTTCTTTGAATACCTAAAAACAGTTTTCA
AAATGGACAGCTCTGTTTTG

Product: two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MGRQHKILIVDDEATIRRILATRLSMVGYEIVVAADGVEALEQFEAEKPDLIVLDVMMPRMNGLQVCQTLRESTGVPIIM
LTALGEVSDRIKGLELGADDYLPKPFSPKELESRIQAILRRTVPGKGKAGAGHAAEQVIMEIGPLRIETHKRQVYLHGQR
IQLTGIEFDVLKLLVSKAGQTVSRSDILQQVWGYSANHYADLRVVDVNVSRLRSKIGDSSKQPEYIHTDWGIGYFFQKMR
KKSPEQVMC

Sequences:

>Translated_249_residues
MGRQHKILIVDDEATIRRILATRLSMVGYEIVVAADGVEALEQFEAEKPDLIVLDVMMPRMNGLQVCQTLRESTGVPIIM
LTALGEVSDRIKGLELGADDYLPKPFSPKELESRIQAILRRTVPGKGKAGAGHAAEQVIMEIGPLRIETHKRQVYLHGQR
IQLTGIEFDVLKLLVSKAGQTVSRSDILQQVWGYSANHYADLRVVDVNVSRLRSKIGDSSKQPEYIHTDWGIGYFFQKMR
KKSPEQVMC
>Mature_248_residues
GRQHKILIVDDEATIRRILATRLSMVGYEIVVAADGVEALEQFEAEKPDLIVLDVMMPRMNGLQVCQTLRESTGVPIIML
TALGEVSDRIKGLELGADDYLPKPFSPKELESRIQAILRRTVPGKGKAGAGHAAEQVIMEIGPLRIETHKRQVYLHGQRI
QLTGIEFDVLKLLVSKAGQTVSRSDILQQVWGYSANHYADLRVVDVNVSRLRSKIGDSSKQPEYIHTDWGIGYFFQKMRK
KSPEQVMC

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=239, Percent_Identity=38.4937238493724, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1786784, Length=233, Percent_Identity=38.1974248927039, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=39.2241379310345, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=37.1794871794872, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI87082012, Length=236, Percent_Identity=37.7118644067797, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=234, Percent_Identity=33.7606837606838, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=33.6206896551724, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=30.9012875536481, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=31.304347826087, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=32.3275862068966, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=29.1845493562232, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=31.7391304347826, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.0512820512821, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=31.4655172413793, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=38.4615384615385, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=41.5841584158416, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=37.1681415929204, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790299, Length=105, Percent_Identity=32.3809523809524, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=37.2549019607843, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27923; Mature: 27792

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRQHKILIVDDEATIRRILATRLSMVGYEIVVAADGVEALEQFEAEKPDLIVLDVMMPR
CCCCEEEEEECCHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCCCEEEEEECCCC
MNGLQVCQTLRESTGVPIIMLTALGEVSDRIKGLELGADDYLPKPFSPKELESRIQAILR
CCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RTVPGKGKAGAGHAAEQVIMEIGPLRIETHKRQVYLHGQRIQLTGIEFDVLKLLVSKAGQ
HCCCCCCCCCCCHHHHHHHHHHCCEEEEECCEEEEEECCEEEEECCHHHHHHHHHHHCCC
TVSRSDILQQVWGYSANHYADLRVVDVNVSRLRSKIGDSSKQPEYIHTDWGIGYFFQKMR
CCHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHH
KKSPEQVMC
HCCCCCCCC
>Mature Secondary Structure 
GRQHKILIVDDEATIRRILATRLSMVGYEIVVAADGVEALEQFEAEKPDLIVLDVMMPR
CCCEEEEEECCHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCCCEEEEEECCCC
MNGLQVCQTLRESTGVPIIMLTALGEVSDRIKGLELGADDYLPKPFSPKELESRIQAILR
CCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RTVPGKGKAGAGHAAEQVIMEIGPLRIETHKRQVYLHGQRIQLTGIEFDVLKLLVSKAGQ
HCCCCCCCCCCCHHHHHHHHHHCCEEEEECCEEEEEECCEEEEECCHHHHHHHHHHHCCC
TVSRSDILQQVWGYSANHYADLRVVDVNVSRLRSKIGDSSKQPEYIHTDWGIGYFFQKMR
CCHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHH
KKSPEQVMC
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]