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The map label for this gene is cbs [H]

Identifier: 158338197

GI number: 158338197

Start: 5144322

End: 5145296

Strand: Reverse

Name: cbs [H]

Synonym: AM1_5090

Alternate gene names: 158338197

Gene position: 5145296-5144322 (Counterclockwise)

Preceding gene: 158338198

Following gene: 158338196

Centisome position: 79.11

GC content: 53.13

Gene sequence:

>975_bases
ATGGACATTAAACACGGCTTTGTCGGCGCAGTTGGCAACACTCCCCTCATTCGCCTCAATAGTTTCAGTGAGCAAACCGG
CTGCGAAATTTTGGGCAAAGCTGAGTTCTTAAATCCGGGGGGGTCCGTTAAGGATCGGGCTGCTCTGTTTATGATCAATG
ACGCTGAAAAAAGAGGGGTGCTTAAACCCGGCGGCACAGTAGTAGAAGGGACGGCAGGTAATACGGGGATTGGCCTGGCC
CATATCTGCAATGCTAAGGGCTACAAATGTTTAATCGTGATTCCCGAAACCCAATCCCAAGAGAAGATGGATGCGTTACG
GCTATTGGGGGCTGAAGTTCGAGCGGTGCCAGCGGTGCCCTATCGTGATCCCAACAACTATGTCAAACTGTCGGGCCGCA
TCGCTGACGAACTAGACAATGCTGTGTGGGCCAACCAATTCGACAATTTGGCCAATCGTCTCGCCCATTATGAAGGCACC
GGCCCCGAAATCTGGCAGCAGACCGATGGCAAGATCGATGCCTGGGTCACCTCCACGGGGACCGGCGGCACCTATGCCGG
AGTAGCTCTCTATCTCAAAGAGCAAAACCCCAATCTCAAAACGATTTTGGCGGACCCCATGGGGAGCGGTCTCTATAGCT
ATGTCAAAACCGGAGAAATTAAGCCGGAAGGCAATTCGGTTACCGAGGGCATTGGCAATAGCCGGGTCACCGCTAATTTG
GAAGGGGCTCCCATCGATGATGCCATTCAAGTGGATGACCCCGAAGCGCTACGGATCATTTACCAGCTATTGCGAGAAGA
TGGCCTGTTTTTAGGGGGATCGGTCGGCATCAATGTGGGCGCAGCGGTCGCCCTCGCCAAAGAGATGGGGCCTGGGCATA
CCATTGTCACGGTGCTTTGTGATAGCGGCACTCGCTATCAGTCTAAGTTGTTTAATCCAGACTGGCTGAAAGCCAAAGGA
CTCAGTCCTGATTAA

Upstream 100 bases:

>100_bases
CTCAATTTTGGGAAACACTGGGACAGCGGAGCCATAACCCTTGGTCACAGCCGGACATGTCGTGGGAAGATAGGCAAATA
TGTAAATCTTTTCCGCGACC

Downstream 100 bases:

>100_bases
TAAAGACTAGCGGTCTATACCCAAGTTAGAGCATATTTTTATGGAGCAGCGATGGAGCTGGGTGAAGCAGCTATGGGCAA
GCTATAAGTCCGTTTTTTTC

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDIKHGFVGAVGNTPLIRLNSFSEQTGCEILGKAEFLNPGGSVKDRAALFMINDAEKRGVLKPGGTVVEGTAGNTGIGLA
HICNAKGYKCLIVIPETQSQEKMDALRLLGAEVRAVPAVPYRDPNNYVKLSGRIADELDNAVWANQFDNLANRLAHYEGT
GPEIWQQTDGKIDAWVTSTGTGGTYAGVALYLKEQNPNLKTILADPMGSGLYSYVKTGEIKPEGNSVTEGIGNSRVTANL
EGAPIDDAIQVDDPEALRIIYQLLREDGLFLGGSVGINVGAAVALAKEMGPGHTIVTVLCDSGTRYQSKLFNPDWLKAKG
LSPD

Sequences:

>Translated_324_residues
MDIKHGFVGAVGNTPLIRLNSFSEQTGCEILGKAEFLNPGGSVKDRAALFMINDAEKRGVLKPGGTVVEGTAGNTGIGLA
HICNAKGYKCLIVIPETQSQEKMDALRLLGAEVRAVPAVPYRDPNNYVKLSGRIADELDNAVWANQFDNLANRLAHYEGT
GPEIWQQTDGKIDAWVTSTGTGGTYAGVALYLKEQNPNLKTILADPMGSGLYSYVKTGEIKPEGNSVTEGIGNSRVTANL
EGAPIDDAIQVDDPEALRIIYQLLREDGLFLGGSVGINVGAAVALAKEMGPGHTIVTVLCDSGTRYQSKLFNPDWLKAKG
LSPD
>Mature_324_residues
MDIKHGFVGAVGNTPLIRLNSFSEQTGCEILGKAEFLNPGGSVKDRAALFMINDAEKRGVLKPGGTVVEGTAGNTGIGLA
HICNAKGYKCLIVIPETQSQEKMDALRLLGAEVRAVPAVPYRDPNNYVKLSGRIADELDNAVWANQFDNLANRLAHYEGT
GPEIWQQTDGKIDAWVTSTGTGGTYAGVALYLKEQNPNLKTILADPMGSGLYSYVKTGEIKPEGNSVTEGIGNSRVTANL
EGAPIDDAIQVDDPEALRIIYQLLREDGLFLGGSVGINVGAAVALAKEMGPGHTIVTVLCDSGTRYQSKLFNPDWLKAKG
LSPD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=42.0382165605096, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=42.0382165605096, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=42.0382165605096, Blast_Score=244, Evalue=7e-65,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=36.5448504983389, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1788754, Length=328, Percent_Identity=37.1951219512195, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=39.6103896103896, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=40.2684563758389, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=38.8157894736842, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=38.1107491856677, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=37.888198757764, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17561720, Length=300, Percent_Identity=38.6666666666667, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=35.7366771159875, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=34.8214285714286, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71996324, Length=327, Percent_Identity=26.605504587156, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539640, Length=339, Percent_Identity=25.9587020648968, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321449, Length=343, Percent_Identity=42.5655976676385, Blast_Score=229, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6321594, Length=342, Percent_Identity=36.8421052631579, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=38.5093167701863, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=38.5093167701863, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34472; Mature: 34472

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKHGFVGAVGNTPLIRLNSFSEQTGCEILGKAEFLNPGGSVKDRAALFMINDAEKRGV
CCCCCCEEEECCCCCEEEEECCCCCCCCEEEECEEEECCCCCCCCCEEEEEEECCCCCCC
LKPGGTVVEGTAGNTGIGLAHICNAKGYKCLIVIPETQSQEKMDALRLLGAEVRAVPAVP
CCCCCEEEECCCCCCCCCHHEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHEEECCCC
YRDPNNYVKLSGRIADELDNAVWANQFDNLANRLAHYEGTGPEIWQQTDGKIDAWVTSTG
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECC
TGGTYAGVALYLKEQNPNLKTILADPMGSGLYSYVKTGEIKPEGNSVTEGIGNSRVTANL
CCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHCCCCCEEEEEE
EGAPIDDAIQVDDPEALRIIYQLLREDGLFLGGSVGINVGAAVALAKEMGPGHTIVTVLC
CCCCCCCCEECCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGTRYQSKLFNPDWLKAKGLSPD
CCCCCHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure
MDIKHGFVGAVGNTPLIRLNSFSEQTGCEILGKAEFLNPGGSVKDRAALFMINDAEKRGV
CCCCCCEEEECCCCCEEEEECCCCCCCCEEEECEEEECCCCCCCCCEEEEEEECCCCCCC
LKPGGTVVEGTAGNTGIGLAHICNAKGYKCLIVIPETQSQEKMDALRLLGAEVRAVPAVP
CCCCCEEEECCCCCCCCCHHEEECCCCCEEEEEECCCCCHHHHHHHHHHCCHHEEECCCC
YRDPNNYVKLSGRIADELDNAVWANQFDNLANRLAHYEGTGPEIWQQTDGKIDAWVTSTG
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECC
TGGTYAGVALYLKEQNPNLKTILADPMGSGLYSYVKTGEIKPEGNSVTEGIGNSRVTANL
CCCCEEEEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHCCCCCEEEEEE
EGAPIDDAIQVDDPEALRIIYQLLREDGLFLGGSVGINVGAAVALAKEMGPGHTIVTVLC
CCCCCCCCEECCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGTRYQSKLFNPDWLKAKGLSPD
CCCCCHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]