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The map label for this gene is glxR [H]

Identifier: 158338053

GI number: 158338053

Start: 4978648

End: 4979511

Strand: Direct

Name: glxR [H]

Synonym: AM1_4940

Alternate gene names: 158338053

Gene position: 4978648-4979511 (Clockwise)

Preceding gene: 158338052

Following gene: 158338057

Centisome position: 76.55

GC content: 51.39

Gene sequence:

>864_bases
ATGCAGGTTGGATTTATCGGTACAGGATTGATGGGGGCTCCGATGGCGGCCCGGCTAGTGGAAGTGGGGCATTCCGTTAT
GGCCTACAATCGCACGGCTTCTAAAGTAGAGCCATTAAGAGGATTAGGCGTTGCGATCACACCCTCCCCCACCCAAGTTA
TTCAATCTGCAGACGTCATCATTCTGATGCTTACTAATGCTGCTGCTATTCAGGAACTGTTGACGCCCACGGCATCGGCC
CTATCAGGACGGACCATTATTCAAATGGGCACCATTGCCCCCGCTGAAAGCAAAGCCATTCACGAACAGGTCCAAGCAGT
CGGTGGCACCTACCTAGAAGCTCCAGTATTAGGCAGCATCCCCGAATCTAAAGCCGGAACGTTACTGGTGATGGCGGGAG
CTGCCCCCCAAGATTTTGAAAATCAACTTCCCCTCCTCAAAGCCTTTGGCCCCGATCCTTTATTAGTCGGTCCGGTGGGC
ACCGCCGCTGCCCTTAAGCTCGCCCTCAACCAGTTGATTGGCGGACTGACCACGGCTTTTGCCACTAGCCTATCCTTCTG
CCAAACCTATGGCGTCGAAGTTGAGACCTTTATGCAGATCCTTAGAAACAGTGCTCTCTACGCTCCCACCTTCGATAAAA
AACTGACCCGAATGTTAGACCAAAATTTCGAGAATCCCAATTTCCCCACCAAACACCTGCTCAAAGACATGACCTTATTT
CAGCAAGCTGCCCAAGCCGAAGGACTGCCTACCGAAAATACTGAAGCAATTCAAACCATAATCCAAAGGGCAATGGCTCA
ATTTGCAAATGCGGATTATTCAGCCCTCTACACAGCAGTGCAGAAGGCTGAGCCCAATGGGTGA

Upstream 100 bases:

>100_bases
CATCATCTTGGGGTCCGTCTTTTCCTCAAACCCGGTACAGCAGTCGAGCGACAATCACTACAGACCATCAGAAAAAACCT
ATTGAGAAAGAGGCAGGGCC

Downstream 100 bases:

>100_bases
TTTGCTGCTAGAGAAATTAGCCAAACCGATAATGCTTGCGCACAGCACTTTGAATGGTCCAAGTACAAGACATGCCCGCC
GGGAACGTCACCAAATCCCC

Product: 3-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQVGFIGTGLMGAPMAARLVEVGHSVMAYNRTASKVEPLRGLGVAITPSPTQVIQSADVIILMLTNAAAIQELLTPTASA
LSGRTIIQMGTIAPAESKAIHEQVQAVGGTYLEAPVLGSIPESKAGTLLVMAGAAPQDFENQLPLLKAFGPDPLLVGPVG
TAAALKLALNQLIGGLTTAFATSLSFCQTYGVEVETFMQILRNSALYAPTFDKKLTRMLDQNFENPNFPTKHLLKDMTLF
QQAAQAEGLPTENTEAIQTIIQRAMAQFANADYSALYTAVQKAEPNG

Sequences:

>Translated_287_residues
MQVGFIGTGLMGAPMAARLVEVGHSVMAYNRTASKVEPLRGLGVAITPSPTQVIQSADVIILMLTNAAAIQELLTPTASA
LSGRTIIQMGTIAPAESKAIHEQVQAVGGTYLEAPVLGSIPESKAGTLLVMAGAAPQDFENQLPLLKAFGPDPLLVGPVG
TAAALKLALNQLIGGLTTAFATSLSFCQTYGVEVETFMQILRNSALYAPTFDKKLTRMLDQNFENPNFPTKHLLKDMTLF
QQAAQAEGLPTENTEAIQTIIQRAMAQFANADYSALYTAVQKAEPNG
>Mature_287_residues
MQVGFIGTGLMGAPMAARLVEVGHSVMAYNRTASKVEPLRGLGVAITPSPTQVIQSADVIILMLTNAAAIQELLTPTASA
LSGRTIIQMGTIAPAESKAIHEQVQAVGGTYLEAPVLGSIPESKAGTLLVMAGAAPQDFENQLPLLKAFGPDPLLVGPVG
TAAALKLALNQLIGGLTTAFATSLSFCQTYGVEVETFMQILRNSALYAPTFDKKLTRMLDQNFENPNFPTKHLLKDMTLF
QQAAQAEGLPTENTEAIQTIIQRAMAQFANADYSALYTAVQKAEPNG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=28.2685512367491, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=32.0557491289199, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=30.2083333333333, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=24.6478873239437, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789092, Length=256, Percent_Identity=23.4375, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574115, Length=247, Percent_Identity=26.7206477732794, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=23.0240549828179, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=23.0240549828179, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30316; Mature: 30316

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVGFIGTGLMGAPMAARLVEVGHSVMAYNRTASKVEPLRGLGVAITPSPTQVIQSADVI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCHHHHHHCCCEE
ILMLTNAAAIQELLTPTASALSGRTIIQMGTIAPAESKAIHEQVQAVGGTYLEAPVLGSI
EEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCC
PESKAGTLLVMAGAAPQDFENQLPLLKAFGPDPLLVGPVGTAAALKLALNQLIGGLTTAF
CCCCCCEEEEEECCCCCCHHHCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
ATSLSFCQTYGVEVETFMQILRNSALYAPTFDKKLTRMLDQNFENPNFPTKHLLKDMTLF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QQAAQAEGLPTENTEAIQTIIQRAMAQFANADYSALYTAVQKAEPNG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQVGFIGTGLMGAPMAARLVEVGHSVMAYNRTASKVEPLRGLGVAITPSPTQVIQSADVI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCHHHHHHCCCEE
ILMLTNAAAIQELLTPTASALSGRTIIQMGTIAPAESKAIHEQVQAVGGTYLEAPVLGSI
EEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCC
PESKAGTLLVMAGAAPQDFENQLPLLKAFGPDPLLVGPVGTAAALKLALNQLIGGLTTAF
CCCCCCEEEEEECCCCCCHHHCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
ATSLSFCQTYGVEVETFMQILRNSALYAPTFDKKLTRMLDQNFENPNFPTKHLLKDMTLF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QQAAQAEGLPTENTEAIQTIIQRAMAQFANADYSALYTAVQKAEPNG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]