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The map label for this gene is panF [H]

Identifier: 158338052

GI number: 158338052

Start: 4977151

End: 4978632

Strand: Direct

Name: panF [H]

Synonym: AM1_4939

Alternate gene names: 158338052

Gene position: 4977151-4978632 (Clockwise)

Preceding gene: 158338051

Following gene: 158338053

Centisome position: 76.53

GC content: 51.01

Gene sequence:

>1482_bases
ATGGAAACACTGATTCCCTATATTGCCATTGCAACCTACTTGCTCGTTACCCTAGGCATCGGCCTGATCGGGTATCGCCA
ACAAAAGAACACCGTCGAAGATTTCTTCTTGGCCAACCGCAATATTGGCCCCATCCTTCTCTTTTTTACCCTGGCCTCCA
CCAACTTCAGCGCCTTCTTTTTCCTGGGATTTGCTGGAGCAGGCTATCGCATTGGCATTAGCTACTATCCAATGATGGCC
TTTGGCACTGGGTTTGCCGCCCTCAGCTTCTACTACATTGGCTACAAAGCCTGGTTGCTAGGTAAACAGAAAGGCTTGAT
TACCCCCTCGGAACTGATTCAAGATCGCCTGCCTAGTCAGCCTCTCAAGCTCCTGTTTATGGCCGTAATGGTCATTTTTA
CCTTGCCCTATCTCACCCTCCAACCCATTGGAGCCGGATATCTCCTCGAAAGCTTAACGGGCGGAGCCATTCCCTATCTT
TGGGGAGCTACCTTATTGACCGTGGCCATCGTCTTCTACGTTTTTTTGGGCGGGATGAAGAGTGTGGCCCTGACGGATGT
GCTGCAAGGGGTGCTGATGTGTGTGCTGATGTTGGTGGCCGTGTTTGCCATTGCCCAAGGCTTAGGAGGCTTCTCTGTTG
CCAACCAAACCATCTACGACCTCAAACCTGCGCTATTTTCGCGAAGTGGCTTAGATCAGTCCTTCACCCCCAAGACTTGG
TTTAGCTACATGTGCCTGTGGTCCTTTACCCTGCCCATGTTTCCGCAGATGTTTATGCGGTTTTACAGCGCGAAAAGCCC
TCAGCCCTTAAAGATCTCGGTCTTGCTCTATCCGATAGTGGCCGGAGTTCTGTTTATTTGCCCGGTGCTGATTGGCGTTT
GGGGACATATTGCTTTCCCGGACTTAGTAGGCAAAGCTGCAGATCAGATTTTCCCAATGATGCTGACGAAATACACATCT
ACTGGGCTATCTTCCCTGGTGATGGTGGGGGCATTGGCAGCCTTTATGTCCACGATGGACTCGCAACTCCTGGCCTTAAG
TTCCATGCTGACACGCGATGTCTATACCGCCTACTTTCGCAAAGACGCCTCTTTAACGGAACAGACGCTGGTCGGTCGGA
TTTGGGTGATTGTTTTAGCTGGCATCGGCTTAGGGATTGCAGCCAACCCCCCAGAGACCATTTTGGCCTTTGCAACCCAA
GCCTTCACTGGATTATCGGTGCTGTTCCCCACTGTAATTGCGGCTTTGTATGGCCGCAACATCAGGGCTTCAAGCTGTCT
CGTTTCCATTGTCGTGGGTGAGTTAGCGGTATTAGGCGTTCAGACCAAAATCATTCCCACTAGCTGGATGCTGGGCTTTT
TACCCGTTGTCCCCATCGTGGCTCTATCGGCCTTGATCATCATCTTGGGGTCCGTCTTTTCCTCAAACCCGGTACAGCAG
TCGAGCGACAATCACTACAGACCATCAGAAAAAACCTATTGA

Upstream 100 bases:

>100_bases
CTGGCTGTTTTACTTTGTGATCTTGCAAGGGGGGCTAGTTCTGGCTGTAGCAGGGATCTCTTCTACCCTGTGGCAAAAGA
CAGAGAGGGACCAGTAGGCC

Downstream 100 bases:

>100_bases
GAAAGAGGCAGGGCCATGCAGGTTGGATTTATCGGTACAGGATTGATGGGGGCTCCGATGGCGGCCCGGCTAGTGGAAGT
GGGGCATTCCGTTATGGCCT

Product: Na+/pantothenate symporter PanF

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
METLIPYIAIATYLLVTLGIGLIGYRQQKNTVEDFFLANRNIGPILLFFTLASTNFSAFFFLGFAGAGYRIGISYYPMMA
FGTGFAALSFYYIGYKAWLLGKQKGLITPSELIQDRLPSQPLKLLFMAVMVIFTLPYLTLQPIGAGYLLESLTGGAIPYL
WGATLLTVAIVFYVFLGGMKSVALTDVLQGVLMCVLMLVAVFAIAQGLGGFSVANQTIYDLKPALFSRSGLDQSFTPKTW
FSYMCLWSFTLPMFPQMFMRFYSAKSPQPLKISVLLYPIVAGVLFICPVLIGVWGHIAFPDLVGKAADQIFPMMLTKYTS
TGLSSLVMVGALAAFMSTMDSQLLALSSMLTRDVYTAYFRKDASLTEQTLVGRIWVIVLAGIGLGIAANPPETILAFATQ
AFTGLSVLFPTVIAALYGRNIRASSCLVSIVVGELAVLGVQTKIIPTSWMLGFLPVVPIVALSALIIILGSVFSSNPVQQ
SSDNHYRPSEKTY

Sequences:

>Translated_493_residues
METLIPYIAIATYLLVTLGIGLIGYRQQKNTVEDFFLANRNIGPILLFFTLASTNFSAFFFLGFAGAGYRIGISYYPMMA
FGTGFAALSFYYIGYKAWLLGKQKGLITPSELIQDRLPSQPLKLLFMAVMVIFTLPYLTLQPIGAGYLLESLTGGAIPYL
WGATLLTVAIVFYVFLGGMKSVALTDVLQGVLMCVLMLVAVFAIAQGLGGFSVANQTIYDLKPALFSRSGLDQSFTPKTW
FSYMCLWSFTLPMFPQMFMRFYSAKSPQPLKISVLLYPIVAGVLFICPVLIGVWGHIAFPDLVGKAADQIFPMMLTKYTS
TGLSSLVMVGALAAFMSTMDSQLLALSSMLTRDVYTAYFRKDASLTEQTLVGRIWVIVLAGIGLGIAANPPETILAFATQ
AFTGLSVLFPTVIAALYGRNIRASSCLVSIVVGELAVLGVQTKIIPTSWMLGFLPVVPIVALSALIIILGSVFSSNPVQQ
SSDNHYRPSEKTY
>Mature_493_residues
METLIPYIAIATYLLVTLGIGLIGYRQQKNTVEDFFLANRNIGPILLFFTLASTNFSAFFFLGFAGAGYRIGISYYPMMA
FGTGFAALSFYYIGYKAWLLGKQKGLITPSELIQDRLPSQPLKLLFMAVMVIFTLPYLTLQPIGAGYLLESLTGGAIPYL
WGATLLTVAIVFYVFLGGMKSVALTDVLQGVLMCVLMLVAVFAIAQGLGGFSVANQTIYDLKPALFSRSGLDQSFTPKTW
FSYMCLWSFTLPMFPQMFMRFYSAKSPQPLKISVLLYPIVAGVLFICPVLIGVWGHIAFPDLVGKAADQIFPMMLTKYTS
TGLSSLVMVGALAAFMSTMDSQLLALSSMLTRDVYTAYFRKDASLTEQTLVGRIWVIVLAGIGLGIAANPPETILAFATQ
AFTGLSVLFPTVIAALYGRNIRASSCLVSIVVGELAVLGVQTKIIPTSWMLGFLPVVPIVALSALIIILGSVFSSNPVQQ
SSDNHYRPSEKTY

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:
GO:0005215: Na+/pantothenate symporter PanF, putative
GO:0005886: Na+/pantothenate symporter PanF, putative
GO:0006810: Na+/pantothenate symporter PanF, putative
GO:0006811: Na+/pantothenate symporter PanF, putative
GO:0006814: Na+/pantothenate symporter PanF, putative
GO:0016020: Na+/pantothenate symporter PanF, putative
GO:0016021: Na+/pantothenate symporter PanF, putative
GO:0055085: Na+/pantothenate symporter PanF, putative

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=446, Percent_Identity=29.8206278026906, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4507031, Length=423, Percent_Identity=23.8770685579196, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI87082237, Length=493, Percent_Identity=27.789046653144, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787251, Length=516, Percent_Identity=25.1937984496124, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648033, Length=422, Percent_Identity=26.303317535545, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356865, Length=422, Percent_Identity=26.303317535545, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53670; Mature: 53670

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLIPYIAIATYLLVTLGIGLIGYRQQKNTVEDFFLANRNIGPILLFFTLASTNFSAFF
CCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
FLGFAGAGYRIGISYYPMMAFGTGFAALSFYYIGYKAWLLGKQKGLITPSELIQDRLPSQ
HEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCC
PLKLLFMAVMVIFTLPYLTLQPIGAGYLLESLTGGAIPYLWGATLLTVAIVFYVFLGGMK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
SVALTDVLQGVLMCVLMLVAVFAIAQGLGGFSVANQTIYDLKPALFSRSGLDQSFTPKTW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCHHH
FSYMCLWSFTLPMFPQMFMRFYSAKSPQPLKISVLLYPIVAGVLFICPVLIGVWGHIAFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVGKAADQIFPMMLTKYTSTGLSSLVMVGALAAFMSTMDSQLLALSSMLTRDVYTAYFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDASLTEQTLVGRIWVIVLAGIGLGIAANPPETILAFATQAFTGLSVLFPTVIAALYGRN
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IRASSCLVSIVVGELAVLGVQTKIIPTSWMLGFLPVVPIVALSALIIILGSVFSSNPVQQ
CCHHHHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSDNHYRPSEKTY
CCCCCCCCCCCCC
>Mature Secondary Structure
METLIPYIAIATYLLVTLGIGLIGYRQQKNTVEDFFLANRNIGPILLFFTLASTNFSAFF
CCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
FLGFAGAGYRIGISYYPMMAFGTGFAALSFYYIGYKAWLLGKQKGLITPSELIQDRLPSQ
HEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCC
PLKLLFMAVMVIFTLPYLTLQPIGAGYLLESLTGGAIPYLWGATLLTVAIVFYVFLGGMK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
SVALTDVLQGVLMCVLMLVAVFAIAQGLGGFSVANQTIYDLKPALFSRSGLDQSFTPKTW
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCHHH
FSYMCLWSFTLPMFPQMFMRFYSAKSPQPLKISVLLYPIVAGVLFICPVLIGVWGHIAFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVGKAADQIFPMMLTKYTSTGLSSLVMVGALAAFMSTMDSQLLALSSMLTRDVYTAYFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDASLTEQTLVGRIWVIVLAGIGLGIAANPPETILAFATQAFTGLSVLFPTVIAALYGRN
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IRASSCLVSIVVGELAVLGVQTKIIPTSWMLGFLPVVPIVALSALIIILGSVFSSNPVQQ
CCHHHHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSDNHYRPSEKTY
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]