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The map label for this gene is lepB [H]

Identifier: 158338021

GI number: 158338021

Start: 4955692

End: 4956288

Strand: Reverse

Name: lepB [H]

Synonym: AM1_4908

Alternate gene names: 158338021

Gene position: 4956288-4955692 (Counterclockwise)

Preceding gene: 158338022

Following gene: 158338020

Centisome position: 76.21

GC content: 52.43

Gene sequence:

>597_bases
ATGACCTCAGAGGATCGGCCCACACCTGAGGCAGCCCCCATTCCCCCGTGGCGTAAACTGTGGCAATCCCAGAAAGACAA
TATCCTCACCCTTGCGATCGCATTGATCCTCGCCCTACTGATTCGAGGATTTGTGGCGGAGTCTCGCTACATTCCTTCCG
TCTCCATGGAGCCCACCTTAACGCCTGGTGATCGAATCGTGGTTGAAAAGCTTTCCTATCGACTCCGCCAACCTGAAGCC
GGCGATATTGTCGTCTTCCATACGCCGTTGCCTTTGCAGGCTGTTGGCTATGCGCCTGAACAAGCGTTTATTAAACGGGT
GATTGGCTTAGAGGGGCAAACCATTGCCGTTCAAAACGGCCAAGTCTATGTGGATGGTCAACCCCTTGCCGAGAATTACA
TTGCCGAAGCCCCTCAATATGAACTAGCTCCCGTTCGAGTGCCTGAAGGCAATCTATTCGTGATGGGAGATAACCGTAAC
AACAGCAATGACTCCCACATTTGGGGGTTTTTACCCCTATCGAATGTAATTGGCCGGGCCAATCTGCGATTCTGGCCCCT
GGAGCATATCAACTGGCTTCGTAGTCCATTGCCTTGA

Upstream 100 bases:

>100_bases
AAGCTCTAATTGATTTAACGGAATATATCCTCAAACGACTCTACTGAGGAGTACCCTAGTGATCTAGAAGATTGATTGTC
CATTTTACGAGAGAACCCCT

Downstream 100 bases:

>100_bases
ACGGATTAGCGCCCCTGAACAACCATATGGCACAATGGGAAACACTGGATATATAAGCTATTAAATCAGGTATTTCTGTG
AGTTCTACTGCGACCAAAGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I-1; Leader peptidase I-1 [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTSEDRPTPEAAPIPPWRKLWQSQKDNILTLAIALILALLIRGFVAESRYIPSVSMEPTLTPGDRIVVEKLSYRLRQPEA
GDIVVFHTPLPLQAVGYAPEQAFIKRVIGLEGQTIAVQNGQVYVDGQPLAENYIAEAPQYELAPVRVPEGNLFVMGDNRN
NSNDSHIWGFLPLSNVIGRANLRFWPLEHINWLRSPLP

Sequences:

>Translated_198_residues
MTSEDRPTPEAAPIPPWRKLWQSQKDNILTLAIALILALLIRGFVAESRYIPSVSMEPTLTPGDRIVVEKLSYRLRQPEA
GDIVVFHTPLPLQAVGYAPEQAFIKRVIGLEGQTIAVQNGQVYVDGQPLAENYIAEAPQYELAPVRVPEGNLFVMGDNRN
NSNDSHIWGFLPLSNVIGRANLRFWPLEHINWLRSPLP
>Mature_197_residues
TSEDRPTPEAAPIPPWRKLWQSQKDNILTLAIALILALLIRGFVAESRYIPSVSMEPTLTPGDRIVVEKLSYRLRQPEAG
DIVVFHTPLPLQAVGYAPEQAFIKRVIGLEGQTIAVQNGQVYVDGQPLAENYIAEAPQYELAPVRVPEGNLFVMGDNRNN
SNDSHIWGFLPLSNVIGRANLRFWPLEHINWLRSPLP

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 22197; Mature: 22066

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEDRPTPEAAPIPPWRKLWQSQKDNILTLAIALILALLIRGFVAESRYIPSVSMEPTL
CCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TPGDRIVVEKLSYRLRQPEAGDIVVFHTPLPLQAVGYAPEQAFIKRVIGLEGQTIAVQNG
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCHHHHHHHHHCCCCCEEEEECC
QVYVDGQPLAENYIAEAPQYELAPVRVPEGNLFVMGDNRNNSNDSHIWGFLPLSNVIGRA
EEEECCCCHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHCCC
NLRFWPLEHINWLRSPLP
CCEEECHHHHHHHHCCCC
>Mature Secondary Structure 
TSEDRPTPEAAPIPPWRKLWQSQKDNILTLAIALILALLIRGFVAESRYIPSVSMEPTL
CCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TPGDRIVVEKLSYRLRQPEAGDIVVFHTPLPLQAVGYAPEQAFIKRVIGLEGQTIAVQNG
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCHHHHHHHHHCCCCCEEEEECC
QVYVDGQPLAENYIAEAPQYELAPVRVPEGNLFVMGDNRNNSNDSHIWGFLPLSNVIGRA
EEEECCCCHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHCCC
NLRFWPLEHINWLRSPLP
CCEEECHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]