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The map label for this gene is hemB [H]

Identifier: 158337916

GI number: 158337916

Start: 4840620

End: 4841600

Strand: Direct

Name: hemB [H]

Synonym: AM1_4803

Alternate gene names: 158337916

Gene position: 4840620-4841600 (Clockwise)

Preceding gene: 158337914

Following gene: 158337919

Centisome position: 74.43

GC content: 51.38

Gene sequence:

>981_bases
ATGTTTCCCACCCATCGCCCGCGCCGTCTTCGCAGCCATCCCCAATTGCGCCGCATGGTGCAAGAAACCGTTGTCACCAC
CAACGATCTGATTTATCCGCTATTTGCCGTGCCGGGTGAAAGCGTGGCTCAAGAAGTCTCATCCATGCCAGGGGTCTACC
AGCTTTCCATCGATAAGGTCGTAGAAGAAGCCAAAGAAGTCTACGACCTGGGCATCCCCGCCGTGATTTTGTTCGGGATT
CCCACTGAAAAAGATACGGATGCCACTGGGGCTTGGCATGATCATGGTATTGTCCAGAAAGCCTCTACTGCCGTCAAAGA
AGCAGTGCCGGATCTAATCGTGATTGTGGATACTTGCCTGTGTGAATACACTCAGCATGGCCATTGTGGCTATTTAGAAA
CGGGGGATTTAACGGGCCGGGTTCTCAACGATCCGACCTTGGAGTTGCTGAAGAAAACCGCCGTCTCTCAAGCAAAAGCT
GGGGCTGATATTATTGCGCCTTCTGGGATGATGGATGGATTTGTACAGGCGATACGGGCAGGACTGGATGAAGGAGGATT
TGAAGACATTCCGATTATGTCCTACGCCGCTAAGTATTCCTCTGCCTACTATGGGCCGTTCCGCGATGCGGCTGAATCTG
CGCCTCAATTTGGAGATCGCAGAACGTATCAAATGGACCCCGCCAATTCCCGCGAGGCCATCAAAGAAATTGAATTGGAT
ATCGCCGAAGGGGCCGACATGCTGATGGTCAAGCCTGCTTTGGCATATATGGATATCATCTGGCAGGTGAAGCAAGCTTC
TAACTTACCCGTTGCAGCTTATAACGTGTCTGGTGAATATTCCATGGTCAAAGCTGCGGCCCTCAACGGTTGGGTGGATG
AAGAAAAAGTCGTGATGGAAACCCTAATGAGCTTTAAGCGTTCAGGAGCCGATATGATTCTCACCTATCATGCCAAGGAT
GCTGCCCGCTGGTTGGGATAG

Upstream 100 bases:

>100_bases
ATAATGAACATCTCTTCATTGGGCGTTAGGAACTGTAATAAGATTTGGATTAAGGCGTCACAAGTCCCCGCCTATCGTTC
ATTGCAGAGTCTTACTGGTT

Downstream 100 bases:

>100_bases
AATCAGACTTCGTTGAACTTAGAAAGCTGGCCTTTTCTTGTATAAAGGCCAGCTTTCTGCTTTTAGCAAGGGGCTGCTAC
CAAGCCATCAACACCTGGCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MFPTHRPRRLRSHPQLRRMVQETVVTTNDLIYPLFAVPGESVAQEVSSMPGVYQLSIDKVVEEAKEVYDLGIPAVILFGI
PTEKDTDATGAWHDHGIVQKASTAVKEAVPDLIVIVDTCLCEYTQHGHCGYLETGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEGGFEDIPIMSYAAKYSSAYYGPFRDAAESAPQFGDRRTYQMDPANSREAIKEIELD
IAEGADMLMVKPALAYMDIIWQVKQASNLPVAAYNVSGEYSMVKAAALNGWVDEEKVVMETLMSFKRSGADMILTYHAKD
AARWLG

Sequences:

>Translated_326_residues
MFPTHRPRRLRSHPQLRRMVQETVVTTNDLIYPLFAVPGESVAQEVSSMPGVYQLSIDKVVEEAKEVYDLGIPAVILFGI
PTEKDTDATGAWHDHGIVQKASTAVKEAVPDLIVIVDTCLCEYTQHGHCGYLETGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEGGFEDIPIMSYAAKYSSAYYGPFRDAAESAPQFGDRRTYQMDPANSREAIKEIELD
IAEGADMLMVKPALAYMDIIWQVKQASNLPVAAYNVSGEYSMVKAAALNGWVDEEKVVMETLMSFKRSGADMILTYHAKD
AARWLG
>Mature_326_residues
MFPTHRPRRLRSHPQLRRMVQETVVTTNDLIYPLFAVPGESVAQEVSSMPGVYQLSIDKVVEEAKEVYDLGIPAVILFGI
PTEKDTDATGAWHDHGIVQKASTAVKEAVPDLIVIVDTCLCEYTQHGHCGYLETGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEGGFEDIPIMSYAAKYSSAYYGPFRDAAESAPQFGDRRTYQMDPANSREAIKEIELD
IAEGADMLMVKPALAYMDIIWQVKQASNLPVAAYNVSGEYSMVKAAALNGWVDEEKVVMETLMSFKRSGADMILTYHAKD
AARWLG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=318, Percent_Identity=38.9937106918239, Blast_Score=245, Evalue=3e-65,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=51.7241379310345, Blast_Score=315, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=40.4388714733542, Blast_Score=233, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21358291, Length=319, Percent_Identity=40.1253918495298, Blast_Score=239, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35771; Mature: 35771

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTHRPRRLRSHPQLRRMVQETVVTTNDLIYPLFAVPGESVAQEVSSMPGVYQLSIDKV
CCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHH
VEEAKEVYDLGIPAVILFGIPTEKDTDATGAWHDHGIVQKASTAVKEAVPDLIVIVDTCL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
CEYTQHGHCGYLETGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVQAIRA
HHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
GLDEGGFEDIPIMSYAAKYSSAYYGPFRDAAESAPQFGDRRTYQMDPANSREAIKEIELD
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYMDIIWQVKQASNLPVAAYNVSGEYSMVKAAALNGWVDEEKVVME
HHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHH
TLMSFKRSGADMILTYHAKDAARWLG
HHHHHHHCCCCEEEEEECHHHHHHCC
>Mature Secondary Structure
MFPTHRPRRLRSHPQLRRMVQETVVTTNDLIYPLFAVPGESVAQEVSSMPGVYQLSIDKV
CCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHH
VEEAKEVYDLGIPAVILFGIPTEKDTDATGAWHDHGIVQKASTAVKEAVPDLIVIVDTCL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
CEYTQHGHCGYLETGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVQAIRA
HHHCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
GLDEGGFEDIPIMSYAAKYSSAYYGPFRDAAESAPQFGDRRTYQMDPANSREAIKEIELD
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYMDIIWQVKQASNLPVAAYNVSGEYSMVKAAALNGWVDEEKVVME
HHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHH
TLMSFKRSGADMILTYHAKDAARWLG
HHHHHHHCCCCEEEEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]