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The map label for this gene is zraS [H]

Identifier: 158337908

GI number: 158337908

Start: 4832931

End: 4834487

Strand: Reverse

Name: zraS [H]

Synonym: AM1_4795

Alternate gene names: 158337908

Gene position: 4834487-4832931 (Counterclockwise)

Preceding gene: 158337909

Following gene: 158337907

Centisome position: 74.33

GC content: 48.81

Gene sequence:

>1557_bases
ATGATCAGTTCTCAGTTAAGTACAGAGTCAAGTGTCCTTTCCACTAATGGGATCGAGCGCAGTTTACCCCCCGAGTGTTT
TGCCAAGGTTTTTCCCTTCCATTTTGTCTTCAATCGCAACTTAGAGATTTTGCAAGCGGGCAAGGTGCTGCAACGCATTG
CTCCTGAGGGGCTGATGGGCGGACAGGTAGATGATTTTTTTCAGATCCAGCGTCCAAAAGTAGCGTTGGAGTTTGATGCC
CTGCTGAAAAAGTCGAAAAAACTGTTTTTAATCGAATCGATTCACCGGGGATTCCAGTTGAAGGGCCAGTTGATGCCCAT
TGAGTCCGAAGATGTGATATTTTTCATCGGCTCTCTCTGGGTCACAGACCTCTCCGATCTCAAAGGCTATGGGGTCAAAC
TGAAGGATTTTGCTACCCATGAACCGACTTCAGATTTTCTCTATCTGCTCCAGGCTCGGTCCACCGCCCTGTCTGACACT
ACCCACATGGCAGAAGAGTTAGCAGCCAAGCAAGTGGAATTAGAGCAAACCTTGCAGATGGTCCAGGAGAAGAACCACAA
TTTGCAGGCAACTCTTAAGCAATTAGAGACCACCCAGGAGCAACTGATTCAATCGGAGAAGATGGCCTCTTTAGGTCAGT
TGATTGCCGGGATCGCCCATGAAATCAATACTCCCCTGGGGGCAATCCGATCCTCAGTAGAAAATATTTCTGACTTTTTA
GAACGCAATTTAGGGGCACTCCCCACCTTTTTCCAGGCTCTAACGGGAGATTGCCAACAATTATTTTCAGAATTGTTGGA
TTCCGCCAACCAGGATCTGGTGATCTTGAGCAGTCGCGAAAAGCGCAAGCTGAAGCGGGGAAATATCCGCATGCTAGAAG
CGGAAGGGATTGATCAGGCGGATGACGTGGCGGATACCTTAGCGGAGCTGAATTATCTAGAAGAGATCGAGGCCATCGTC
CCCCGACTGCAGTCTGCAGAAGGACGCCAGACCTTGGATATGGCCTATCAGTTTTCAACCTTGTTAAACAGCACTAAGAC
CATCAAAACTGCCACGGACAAAGCAGCCAAAGTCGTCTTTGCCCTGAAGAGCTATTCTCACTTTGACCATACCGGCCAAA
AGTCCCCCACCAACCTTATCTACGATATTGAAACGGTTTTAACCCTTTACCAGAGTCAGCTTAAAAATGGGGTCGAGGTC
ATTCGCAATTATGATCCCATTCCATCGGTGTCCTGTTTCCACGATGAGCTGAGCCAGGTCTGGACCAATCTGATTCATAA
CGCCCTGCAGGCCATGGATTATCAAGGCACCTTAACCCTGGATGTCCAGCACCATGAGAATCAGGTCCAGGTCAAAATTG
CCGACAGCGGTCAGGGAATCCCCGCAGAAGTGATGCCCAAAATATTCCAACCGTTCTTCACCACCAAGCCCCCTGGAGAA
GGCAGCGGTTTGGGCCTCGATATTGTCCATAAGATCGTGAAGAAACATGAGGGCGATATTTCCGTGGTATCTGAACCTGG
GAAAACCCAATTTACCGTGTCTATCCCCCTGACTTAG

Upstream 100 bases:

>100_bases
CTAGCCCCCATGGTCATGGGATTGGTAGAAGGGCTGGGGGAACGATTTGAAACAGAGGTAGATATCAACCAGACCCACAG
CCGCGAGGAGGGCGCCGACC

Downstream 100 bases:

>100_bases
GGCAGGAGACAATTTGAACTCGACTAGCAATGGATCAATGTGATGGTTAAGCCCGTCGTTTTATGTGTAGATGATGAAAA
AGTTATTTTAGACAGTCTCA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MISSQLSTESSVLSTNGIERSLPPECFAKVFPFHFVFNRNLEILQAGKVLQRIAPEGLMGGQVDDFFQIQRPKVALEFDA
LLKKSKKLFLIESIHRGFQLKGQLMPIESEDVIFFIGSLWVTDLSDLKGYGVKLKDFATHEPTSDFLYLLQARSTALSDT
THMAEELAAKQVELEQTLQMVQEKNHNLQATLKQLETTQEQLIQSEKMASLGQLIAGIAHEINTPLGAIRSSVENISDFL
ERNLGALPTFFQALTGDCQQLFSELLDSANQDLVILSSREKRKLKRGNIRMLEAEGIDQADDVADTLAELNYLEEIEAIV
PRLQSAEGRQTLDMAYQFSTLLNSTKTIKTATDKAAKVVFALKSYSHFDHTGQKSPTNLIYDIETVLTLYQSQLKNGVEV
IRNYDPIPSVSCFHDELSQVWTNLIHNALQAMDYQGTLTLDVQHHENQVQVKIADSGQGIPAEVMPKIFQPFFTTKPPGE
GSGLGLDIVHKIVKKHEGDISVVSEPGKTQFTVSIPLT

Sequences:

>Translated_518_residues
MISSQLSTESSVLSTNGIERSLPPECFAKVFPFHFVFNRNLEILQAGKVLQRIAPEGLMGGQVDDFFQIQRPKVALEFDA
LLKKSKKLFLIESIHRGFQLKGQLMPIESEDVIFFIGSLWVTDLSDLKGYGVKLKDFATHEPTSDFLYLLQARSTALSDT
THMAEELAAKQVELEQTLQMVQEKNHNLQATLKQLETTQEQLIQSEKMASLGQLIAGIAHEINTPLGAIRSSVENISDFL
ERNLGALPTFFQALTGDCQQLFSELLDSANQDLVILSSREKRKLKRGNIRMLEAEGIDQADDVADTLAELNYLEEIEAIV
PRLQSAEGRQTLDMAYQFSTLLNSTKTIKTATDKAAKVVFALKSYSHFDHTGQKSPTNLIYDIETVLTLYQSQLKNGVEV
IRNYDPIPSVSCFHDELSQVWTNLIHNALQAMDYQGTLTLDVQHHENQVQVKIADSGQGIPAEVMPKIFQPFFTTKPPGE
GSGLGLDIVHKIVKKHEGDISVVSEPGKTQFTVSIPLT
>Mature_518_residues
MISSQLSTESSVLSTNGIERSLPPECFAKVFPFHFVFNRNLEILQAGKVLQRIAPEGLMGGQVDDFFQIQRPKVALEFDA
LLKKSKKLFLIESIHRGFQLKGQLMPIESEDVIFFIGSLWVTDLSDLKGYGVKLKDFATHEPTSDFLYLLQARSTALSDT
THMAEELAAKQVELEQTLQMVQEKNHNLQATLKQLETTQEQLIQSEKMASLGQLIAGIAHEINTPLGAIRSSVENISDFL
ERNLGALPTFFQALTGDCQQLFSELLDSANQDLVILSSREKRKLKRGNIRMLEAEGIDQADDVADTLAELNYLEEIEAIV
PRLQSAEGRQTLDMAYQFSTLLNSTKTIKTATDKAAKVVFALKSYSHFDHTGQKSPTNLIYDIETVLTLYQSQLKNGVEV
IRNYDPIPSVSCFHDELSQVWTNLIHNALQAMDYQGTLTLDVQHHENQVQVKIADSGQGIPAEVMPKIFQPFFTTKPPGE
GSGLGLDIVHKIVKKHEGDISVVSEPGKTQFTVSIPLT

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194595474, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194595476, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194595472, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI67763816, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194595482, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194595478, Length=217, Percent_Identity=26.7281105990783, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4504215, Length=208, Percent_Identity=26.4423076923077, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4504211, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790436, Length=114, Percent_Identity=41.2280701754386, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790300, Length=247, Percent_Identity=29.9595141700405, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=125, Percent_Identity=39.2, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=169, Percent_Identity=33.7278106508876, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=104, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=153, Percent_Identity=30.0653594771242, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=147, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24651577, Length=190, Percent_Identity=28.4210526315789, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57749; Mature: 57749

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00958 TRANSALDOLASE_2 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSQLSTESSVLSTNGIERSLPPECFAKVFPFHFVFNRNLEILQAGKVLQRIAPEGLMG
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCC
GQVDDFFQIQRPKVALEFDALLKKSKKLFLIESIHRGFQLKGQLMPIESEDVIFFIGSLW
CCCHHHHHCCCCCEEHHHHHHHHCCCCEEEHHHHHCCCEECCCEECCCCCCEEEEEHHHH
VTDLSDLKGYGVKLKDFATHEPTSDFLYLLQARSTALSDTTHMAEELAAKQVELEQTLQM
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQEKNHNLQATLKQLETTQEQLIQSEKMASLGQLIAGIAHEINTPLGAIRSSVENISDFL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ERNLGALPTFFQALTGDCQQLFSELLDSANQDLVILSSREKRKLKRGNIRMLEAEGIDQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCEEEEECCCCCCH
DDVADTLAELNYLEEIEAIVPRLQSAEGRQTLDMAYQFSTLLNSTKTIKTATDKAAKVVF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALKSYSHFDHTGQKSPTNLIYDIETVLTLYQSQLKNGVEVIRNYDPIPSVSCFHDELSQV
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
WTNLIHNALQAMDYQGTLTLDVQHHENQVQVKIADSGQGIPAEVMPKIFQPFFTTKPPGE
HHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCC
GSGLGLDIVHKIVKKHEGDISVVSEPGKTQFTVSIPLT
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCC
>Mature Secondary Structure
MISSQLSTESSVLSTNGIERSLPPECFAKVFPFHFVFNRNLEILQAGKVLQRIAPEGLMG
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCC
GQVDDFFQIQRPKVALEFDALLKKSKKLFLIESIHRGFQLKGQLMPIESEDVIFFIGSLW
CCCHHHHHCCCCCEEHHHHHHHHCCCCEEEHHHHHCCCEECCCEECCCCCCEEEEEHHHH
VTDLSDLKGYGVKLKDFATHEPTSDFLYLLQARSTALSDTTHMAEELAAKQVELEQTLQM
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQEKNHNLQATLKQLETTQEQLIQSEKMASLGQLIAGIAHEINTPLGAIRSSVENISDFL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ERNLGALPTFFQALTGDCQQLFSELLDSANQDLVILSSREKRKLKRGNIRMLEAEGIDQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCEEEEECCCCCCH
DDVADTLAELNYLEEIEAIVPRLQSAEGRQTLDMAYQFSTLLNSTKTIKTATDKAAKVVF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALKSYSHFDHTGQKSPTNLIYDIETVLTLYQSQLKNGVEVIRNYDPIPSVSCFHDELSQV
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
WTNLIHNALQAMDYQGTLTLDVQHHENQVQVKIADSGQGIPAEVMPKIFQPFFTTKPPGE
HHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCC
GSGLGLDIVHKIVKKHEGDISVVSEPGKTQFTVSIPLT
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]