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The map label for this gene is desA [H]

Identifier: 158337775

GI number: 158337775

Start: 4693740

End: 4694792

Strand: Reverse

Name: desA [H]

Synonym: AM1_4659

Alternate gene names: 158337775

Gene position: 4694792-4693740 (Counterclockwise)

Preceding gene: 158337777

Following gene: 158337774

Centisome position: 72.19

GC content: 47.96

Gene sequence:

>1053_bases
ATGACTGCATCCCTTGTCAAGTCTGACCCTCAACTGCGGACACTCACCGATCCGGACATAACCCTTCAAGATGTTATCAA
ATCTCTGCCCAAGGAATGCTTTAAGCAAAATGCAGTAAAGGCTTGGACAGGGGCGATCATCAATGTGCTGATGGTGGCTC
TAGGTTATGTCGCAATTGTTAATTCTCCTTGGTATTTGCTGCCCCTAGCCTGGATCTTTACGGGCACAGCACTAACGGGT
TTCTTTGTGATTGGTCATGATGCCGGGCATCGCTCTTTTGCTAAGAAGCGCTGGGTCAATGATGTAGTGGGTCATCTATT
TATGATGCCGCTGATCTATCCTTTTCACTGCTGGCGGATTTTGCACAACTTCCACCATACCCATACCAATGAGCTGGATG
TGGATAATGCCTGGCGGCCCTTTGATGGGGCTGAGTATGAAAGCCTTGATCCGGTAATTCGAACGGTTTATGAGCTGATT
CGCGGTTATTTTTGGTGGGTGGGTTCCATTGTTCATTGGGCCAATCTCCACTTCAACTGGACCACCTTTGATGAGAAAGA
TAAAGGTGATGTCAAGCTCTCTATCGGCGTTGTGGTAGTGTTCGCTGCGATCGCATTCCCGACTCTGATCTACTTCACTG
GCATTTGGGGCTTCGTCAAGTTCTGGTTGATTCCTTGGATGGTCTACCACTTCTGGATGAGCACCTTCACTATCGTTCAC
CACACCGCCTCCGATATTCCGTTTCAACCCACAGAAGTCTGGAACGCTGCAGAAGCTCAGCTGGTGGGTTCAGTGCACTG
CAAATATCCAGGTTGGGTTGAGTTTCTCTGCCACGATATCAATGTCCATATTCCTCACCATGTATCTACCGCGATTCCTT
CTTACAATTTACGCATGGCCCATCAAAGCCTGAAGGACAATTGGGGTCAGTACGTGTATGAGCGCGAATTCAACTGGGCC
TTGATGAAAGAAATTTCAGAAGAATGCCATCTCTACGATTCTGAAAAAGCCTATCGGTCCTTTAAAGATCACCGTGCAGC
TAAGCGCGATTAG

Upstream 100 bases:

>100_bases
TGGATTTAACCGTCCAAGCTTGAAGCATTACACCCTGCTTGGTCCCCTGCCATAGGGTGCTTGATCACGTATTTCAGCTC
AGGAGATTCCTAATTCAGCT

Downstream 100 bases:

>100_bases
CAATGCTCAACCTTAAAGGGGTCAATCTTTACCTCGTCGGCATGATGGGGTGTGGCAAATCGACAACAGGCCGGGCCTTA
GCGAAACAACTAGGCTACGG

Product: fatty acid desaturase

Products: NA

Alternate protein names: Delta(12) desaturase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTASLVKSDPQLRTLTDPDITLQDVIKSLPKECFKQNAVKAWTGAIINVLMVALGYVAIVNSPWYLLPLAWIFTGTALTG
FFVIGHDAGHRSFAKKRWVNDVVGHLFMMPLIYPFHCWRILHNFHHTHTNELDVDNAWRPFDGAEYESLDPVIRTVYELI
RGYFWWVGSIVHWANLHFNWTTFDEKDKGDVKLSIGVVVVFAAIAFPTLIYFTGIWGFVKFWLIPWMVYHFWMSTFTIVH
HTASDIPFQPTEVWNAAEAQLVGSVHCKYPGWVEFLCHDINVHIPHHVSTAIPSYNLRMAHQSLKDNWGQYVYEREFNWA
LMKEISEECHLYDSEKAYRSFKDHRAAKRD

Sequences:

>Translated_350_residues
MTASLVKSDPQLRTLTDPDITLQDVIKSLPKECFKQNAVKAWTGAIINVLMVALGYVAIVNSPWYLLPLAWIFTGTALTG
FFVIGHDAGHRSFAKKRWVNDVVGHLFMMPLIYPFHCWRILHNFHHTHTNELDVDNAWRPFDGAEYESLDPVIRTVYELI
RGYFWWVGSIVHWANLHFNWTTFDEKDKGDVKLSIGVVVVFAAIAFPTLIYFTGIWGFVKFWLIPWMVYHFWMSTFTIVH
HTASDIPFQPTEVWNAAEAQLVGSVHCKYPGWVEFLCHDINVHIPHHVSTAIPSYNLRMAHQSLKDNWGQYVYEREFNWA
LMKEISEECHLYDSEKAYRSFKDHRAAKRD
>Mature_349_residues
TASLVKSDPQLRTLTDPDITLQDVIKSLPKECFKQNAVKAWTGAIINVLMVALGYVAIVNSPWYLLPLAWIFTGTALTGF
FVIGHDAGHRSFAKKRWVNDVVGHLFMMPLIYPFHCWRILHNFHHTHTNELDVDNAWRPFDGAEYESLDPVIRTVYELIR
GYFWWVGSIVHWANLHFNWTTFDEKDKGDVKLSIGVVVVFAAIAFPTLIYFTGIWGFVKFWLIPWMVYHFWMSTFTIVHH
TASDIPFQPTEVWNAAEAQLVGSVHCKYPGWVEFLCHDINVHIPHHVSTAIPSYNLRMAHQSLKDNWGQYVYEREFNWAL
MKEISEECHLYDSEKAYRSFKDHRAAKRD

Specific function: Can introduce a second cis double bond at the Delta(12) position of fatty acid bound to membranes glycerolipids. This enzyme is involved in chilling tolerance because the phase transition temperature of lipids of cellular membranes depends on the degree o

COG id: COG3239

COG function: function code I; Fatty acid desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fatty acid desaturase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17542730, Length=333, Percent_Identity=27.3273273273273, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71999459, Length=138, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005804
- InterPro:   IPR005803 [H]

Pfam domain/function: PF00487 FA_desaturase [H]

EC number: 1.14.99.-

Molecular weight: Translated: 40761; Mature: 40630

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASLVKSDPQLRTLTDPDITLQDVIKSLPKECFKQNAVKAWTGAIINVLMVALGYVAIV
CCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSPWYLLPLAWIFTGTALTGFFVIGHDAGHRSFAKKRWVNDVVGHLFMMPLIYPFHCWRI
CCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHNFHHTHTNELDVDNAWRPFDGAEYESLDPVIRTVYELIRGYFWWVGSIVHWANLHFNW
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TTFDEKDKGDVKLSIGVVVVFAAIAFPTLIYFTGIWGFVKFWLIPWMVYHFWMSTFTIVH
EECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTASDIPFQPTEVWNAAEAQLVGSVHCKYPGWVEFLCHDINVHIPHHVSTAIPSYNLRMA
HHCCCCCCCCHHHHCHHHHHHHHCEECCCCHHHHHHHHHCCEECCCHHHHHCCCCHHHHH
HQSLKDNWGQYVYEREFNWALMKEISEECHLYDSEKAYRSFKDHRAAKRD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TASLVKSDPQLRTLTDPDITLQDVIKSLPKECFKQNAVKAWTGAIINVLMVALGYVAIV
CCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSPWYLLPLAWIFTGTALTGFFVIGHDAGHRSFAKKRWVNDVVGHLFMMPLIYPFHCWRI
CCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHNFHHTHTNELDVDNAWRPFDGAEYESLDPVIRTVYELIRGYFWWVGSIVHWANLHFNW
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TTFDEKDKGDVKLSIGVVVVFAAIAFPTLIYFTGIWGFVKFWLIPWMVYHFWMSTFTIVH
EECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTASDIPFQPTEVWNAAEAQLVGSVHCKYPGWVEFLCHDINVHIPHHVSTAIPSYNLRMA
HHCCCCCCCCHHHHCHHHHHHHHCEECCCCHHHHHHHHHCCEECCCHHHHHCCCCHHHHH
HQSLKDNWGQYVYEREFNWALMKEISEECHLYDSEKAYRSFKDHRAAKRD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118597; 8905231 [H]