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The map label for this gene is aroK [H]

Identifier: 158337774

GI number: 158337774

Start: 4693189

End: 4693737

Strand: Reverse

Name: aroK [H]

Synonym: AM1_4657

Alternate gene names: 158337774

Gene position: 4693737-4693189 (Counterclockwise)

Preceding gene: 158337775

Following gene: 158337770

Centisome position: 72.17

GC content: 51.37

Gene sequence:

>549_bases
ATGCTCAACCTTAAAGGGGTCAATCTTTACCTCGTCGGCATGATGGGGTGTGGCAAATCGACAACAGGCCGGGCCTTAGC
GAAACAACTAGGCTACGGCTTTGTTGATACGGATGACCTAATTACCCAACTCACGGGGCAAGCGATTACCGATATTTTTG
CTGAATCGGGAGAAGACCATTTTCGCCAAGTTGAATCTAAAGTCTTGTCCGAAGTGGCTGCTCACACCAACCTCGTGGTG
GCCACAGGCGGCGGAATTGTTCTAGATAAAAAGAACTGGAGCTTTTTGCAACATGGCCTCGTCATCTGGCTGGATGTAGA
AGCCGAACAGCTATGGCAGCGCCTTCAGGCAGACCAGTCCCGGCCTTTGCTGCAAAAACCAAATCCCCAACAAGTTTTAG
AAGAATTGCTAACTCAACGGCGGCCCCTCTATCGACAAGCCGATGTTCACATCTTGCTTAAGCCGGATCAGTCCGTTGAG
TCGGTCTGCGAATCCGTCGTCCAAGAGATCACCAAAGTGCTGCGCCCCGAGGCTAGCCCTCAGGATTAA

Upstream 100 bases:

>100_bases
GGGCCTTGATGAAAGAAATTTCAGAAGAATGCCATCTCTACGATTCTGAAAAAGCCTATCGGTCCTTTAAAGATCACCGT
GCAGCTAAGCGCGATTAGCA

Downstream 100 bases:

>100_bases
GTCGTCGCTGCTGCCGTCGCTGCCGCCGTCGCTCTGCTAGCTTTTGCTCTAACCGCTGCCGTTGCTCTGGTGAGAGGACT
TTGCGAATCGCCATCATATT

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MLNLKGVNLYLVGMMGCGKSTTGRALAKQLGYGFVDTDDLITQLTGQAITDIFAESGEDHFRQVESKVLSEVAAHTNLVV
ATGGGIVLDKKNWSFLQHGLVIWLDVEAEQLWQRLQADQSRPLLQKPNPQQVLEELLTQRRPLYRQADVHILLKPDQSVE
SVCESVVQEITKVLRPEASPQD

Sequences:

>Translated_182_residues
MLNLKGVNLYLVGMMGCGKSTTGRALAKQLGYGFVDTDDLITQLTGQAITDIFAESGEDHFRQVESKVLSEVAAHTNLVV
ATGGGIVLDKKNWSFLQHGLVIWLDVEAEQLWQRLQADQSRPLLQKPNPQQVLEELLTQRRPLYRQADVHILLKPDQSVE
SVCESVVQEITKVLRPEASPQD
>Mature_182_residues
MLNLKGVNLYLVGMMGCGKSTTGRALAKQLGYGFVDTDDLITQLTGQAITDIFAESGEDHFRQVESKVLSEVAAHTNLVV
ATGGGIVLDKKNWSFLQHGLVIWLDVEAEQLWQRLQADQSRPLLQKPNPQQVLEELLTQRRPLYRQADVHILLKPDQSVE
SVCESVVQEITKVLRPEASPQD

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:
GO:0000166: Shikimate kinase
GO:0000287: Shikimate kinase
GO:0004765: Shikimate kinase
GO:0005524: Shikimate kinase
GO:0005737: Shikimate kinase
GO:0008652: Shikimate kinase
GO:0009073: Shikimate kinase
GO:0016301: Shikimate kinase
GO:0016310: Shikimate kinase
GO:0016740: Shikimate kinase
GO:0046872: Shikimate kinase

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=167, Percent_Identity=26.3473053892216, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082255, Length=164, Percent_Identity=40.8536585365854, Blast_Score=113, Evalue=8e-27,
Organism=Escherichia coli, GI1786587, Length=171, Percent_Identity=36.2573099415205, Blast_Score=88, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=176, Percent_Identity=26.7045454545455, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 20261; Mature: 20261

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01128 SHIKIMATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLKGVNLYLVGMMGCGKSTTGRALAKQLGYGFVDTDDLITQLTGQAITDIFAESGEDH
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
FRQVESKVLSEVAAHTNLVVATGGGIVLDKKNWSFLQHGLVIWLDVEAEQLWQRLQADQS
HHHHHHHHHHHHHHHCCEEEEECCEEEEECCCHHHHHCCEEEEEECCHHHHHHHHHHCCC
RPLLQKPNPQQVLEELLTQRRPLYRQADVHILLKPDQSVESVCESVVQEITKVLRPEASP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
QD
CC
>Mature Secondary Structure
MLNLKGVNLYLVGMMGCGKSTTGRALAKQLGYGFVDTDDLITQLTGQAITDIFAESGEDH
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
FRQVESKVLSEVAAHTNLVVATGGGIVLDKKNWSFLQHGLVIWLDVEAEQLWQRLQADQS
HHHHHHHHHHHHHHHCCEEEEECCEEEEECCCHHHHHCCEEEEEECCHHHHHHHHHHCCC
RPLLQKPNPQQVLEELLTQRRPLYRQADVHILLKPDQSVESVCESVVQEITKVLRPEASP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA