Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 158337547

GI number: 158337547

Start: 4452270

End: 4453895

Strand: Direct

Name: guaA [H]

Synonym: AM1_4428

Alternate gene names: 158337547

Gene position: 4452270-4453895 (Clockwise)

Preceding gene: 158337546

Following gene: 158337548

Centisome position: 68.46

GC content: 51.85

Gene sequence:

>1626_bases
GTGCCTTCTCAGACCCAGCAACCTCTCTCTGCTCATCCTCAAGACTCCACATTTGCCCAGACCCCTGTCGACCGGCAAAT
GATTGTCATTCTTGATTTTGGCTCCCAGTACTCTGAACTTATCGCTCGTCGCATTCGCGAGACCCAAGTCTATTCAGAAG
TATTGTCTTATCGCACATCTATAGAGCAGCTACGACAGCTTAATCCCAAAGGCATCATCTTGTCCGGTGGTCCTAATTCT
GTCTATGCCCAACATGCTCCTGCTTGTGATCCCGAGATTTGGAACCTGGGTATTCCTGTGTTAGGGGTTTGCTACGGCAT
GCAGCTGATGGTGCAACAGTTGGGTGGGCAGGTAGAAGCCTCTGACGCAGCCGAATATGGGAAAGCCTCCCTAATTATTG
ATGACCCTACAGATTTACTCACCAACGTCGAAGATCAAACCACCATGTGGATGAGTCATGGAGATTCCGTGACTGCTCTA
CCGGAAGGGTTTAAAGTCTTAGCTCACACCGCCAACACGCCTCAAGCTGCCGTTGCCCACCATGATCGCCAGCTCTACGG
CGTCCAGTTCCACCCTGAAGTGGTGCACTCTCAAGGGGGACAGGCCCTGATCTGTAACTTTGTCTATCATATTTGCGAAT
GTGAGCCGACTTGGACGACAGAGGCTTTTGTTGAAGAGGCCATTCGCGAAGTTCGGGCCAAGGTCGGGAATAAGCGGGTG
CTACTGGCTCTTTCCGGCGGCGTAGATTCTTCGACCCTAGCCTTTCTTCTCCATAAGGCGATTGGCGACAACTTAACCTG
CATGTTTATTGACCAAGGGTTTATGCGCAAGCTGGAACCTGAGCGTCTAATCAAGCTATTTCGAGACCAGTTTCACATCC
CCGTGGAATATGTGATGGCTCGCGATCGGTTTTTAGAACGGCTGAATGGCATCACCGATCCAGAAGAAAAGCGCAAACGG
ATTGGCCATGAGTTTATCCAAGTGTTTGAAGAAGAATCCCGACGGCTAGGCCCCTTCGACTACCTCGCCCAGGGCACCCT
CTATCCTGATGTGATCGAATCTGCCGACACCAATGTCGACCCAGCCACAGGGGAACGAGTGGCCGTCAAGATTAAGAGTC
ACCACAACGTCGGTGGACTTCCGAAAGATCTGCGGTTCAAGTTGGTCGAACCCTTGCGGAAGCTCTTCAAAGACGAAGTC
CGTAAGGTCGGTCGCTCCCTCGGGTTGCCAGAAGAGATTGTCAACCGCCATCCATTCCCAGGACCCGGCTTAGCCATTCG
GATTATTGGGGAAGTCACAGCAGAACGTCTGAATATTCTCCGGGATGCTGATTTAATTGTGCGCCAAGAAGTCAATCGAT
CCGGAAATTACAGTGAGTTTTGGCAAGCTTTCGCGGTATTATTGCCCGTCCGTAGCGTCGGGGTGATGGGGGATCAACGC
ACCTATGCCTACCCAGTGGTGCTGCGGTTTGTCTCTAGCGAAGATGGCATGACCGCAGACTGGTCCCGTGCTCCCTATGA
ACTCTTGGAAACGATTTCCAACCGTATCGTCAATGAGGTGAAGGGCGTCAATCGAGTTGCCTACGATATCACCTCCAAAC
CTCCAGGAACCATCGAATGGGAATAG

Upstream 100 bases:

>100_bases
ATCGCTAGTTATCCATACTTCGGGTTCTAGGGTTTTCTAATTTTTTGTTTAACTTTTCTATCTAAACCCTGCCCCCTCAT
CACTCAAAGGGATACCTTCC

Downstream 100 bases:

>100_bases
AGCATCTTCACGGTATGTTCGCCAAGCCTGGCCACAAGGGCTGATAATAGTGTTATTCAGTACAATGACACGTTAGAACA
TGACTAGTGGTGAAACCACA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPSQTQQPLSAHPQDSTFAQTPVDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTSIEQLRQLNPKGIILSGGPNS
VYAQHAPACDPEIWNLGIPVLGVCYGMQLMVQQLGGQVEASDAAEYGKASLIIDDPTDLLTNVEDQTTMWMSHGDSVTAL
PEGFKVLAHTANTPQAAVAHHDRQLYGVQFHPEVVHSQGGQALICNFVYHICECEPTWTTEAFVEEAIREVRAKVGNKRV
LLALSGGVDSSTLAFLLHKAIGDNLTCMFIDQGFMRKLEPERLIKLFRDQFHIPVEYVMARDRFLERLNGITDPEEKRKR
IGHEFIQVFEEESRRLGPFDYLAQGTLYPDVIESADTNVDPATGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEV
RKVGRSLGLPEEIVNRHPFPGPGLAIRIIGEVTAERLNILRDADLIVRQEVNRSGNYSEFWQAFAVLLPVRSVGVMGDQR
TYAYPVVLRFVSSEDGMTADWSRAPYELLETISNRIVNEVKGVNRVAYDITSKPPGTIEWE

Sequences:

>Translated_541_residues
MPSQTQQPLSAHPQDSTFAQTPVDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTSIEQLRQLNPKGIILSGGPNS
VYAQHAPACDPEIWNLGIPVLGVCYGMQLMVQQLGGQVEASDAAEYGKASLIIDDPTDLLTNVEDQTTMWMSHGDSVTAL
PEGFKVLAHTANTPQAAVAHHDRQLYGVQFHPEVVHSQGGQALICNFVYHICECEPTWTTEAFVEEAIREVRAKVGNKRV
LLALSGGVDSSTLAFLLHKAIGDNLTCMFIDQGFMRKLEPERLIKLFRDQFHIPVEYVMARDRFLERLNGITDPEEKRKR
IGHEFIQVFEEESRRLGPFDYLAQGTLYPDVIESADTNVDPATGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEV
RKVGRSLGLPEEIVNRHPFPGPGLAIRIIGEVTAERLNILRDADLIVRQEVNRSGNYSEFWQAFAVLLPVRSVGVMGDQR
TYAYPVVLRFVSSEDGMTADWSRAPYELLETISNRIVNEVKGVNRVAYDITSKPPGTIEWE
>Mature_540_residues
PSQTQQPLSAHPQDSTFAQTPVDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTSIEQLRQLNPKGIILSGGPNSV
YAQHAPACDPEIWNLGIPVLGVCYGMQLMVQQLGGQVEASDAAEYGKASLIIDDPTDLLTNVEDQTTMWMSHGDSVTALP
EGFKVLAHTANTPQAAVAHHDRQLYGVQFHPEVVHSQGGQALICNFVYHICECEPTWTTEAFVEEAIREVRAKVGNKRVL
LALSGGVDSSTLAFLLHKAIGDNLTCMFIDQGFMRKLEPERLIKLFRDQFHIPVEYVMARDRFLERLNGITDPEEKRKRI
GHEFIQVFEEESRRLGPFDYLAQGTLYPDVIESADTNVDPATGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSLGLPEEIVNRHPFPGPGLAIRIIGEVTAERLNILRDADLIVRQEVNRSGNYSEFWQAFAVLLPVRSVGVMGDQRT
YAYPVVLRFVSSEDGMTADWSRAPYELLETISNRIVNEVKGVNRVAYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:
GO:0000166: GMP synthase [glutamine-hydrolyzing]
GO:0003824: GMP synthase [glutamine-hydrolyzing]
GO:0003922: GMP synthase [glutamine-hydrolyzing]
GO:0005524: GMP synthase [glutamine-hydrolyzing]
GO:0006164: GMP synthase [glutamine-hydrolyzing]
GO:0006177: GMP synthase [glutamine-hydrolyzing]
GO:0006541: GMP synthase [glutamine-hydrolyzing]
GO:0009058: GMP synthase [glutamine-hydrolyzing]
GO:0016874: GMP synthase [glutamine-hydrolyzing]

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=38.0434782608696, Blast_Score=330, Evalue=3e-90,
Organism=Escherichia coli, GI1788854, Length=527, Percent_Identity=50.6641366223909, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1789760, Length=198, Percent_Identity=26.7676767676768, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787517, Length=207, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=576, Percent_Identity=37.6736111111111, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=37.9790940766551, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI71992717, Length=576, Percent_Identity=37.6736111111111, Blast_Score=320, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=48.7523992322457, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322638, Length=193, Percent_Identity=27.4611398963731, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=37.2549019607843, Blast_Score=323, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 60761; Mature: 60630

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSQTQQPLSAHPQDSTFAQTPVDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTS
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
IEQLRQLNPKGIILSGGPNSVYAQHAPACDPEIWNLGIPVLGVCYGMQLMVQQLGGQVEA
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCC
SDAAEYGKASLIIDDPTDLLTNVEDQTTMWMSHGDSVTALPEGFKVLAHTANTPQAAVAH
CHHHHCCCEEEEEECCHHHHHCCCHHHEEEHCCCCCEEECCCCCEEEEECCCCCHHHHHH
HDRQLYGVQFHPEVVHSQGGQALICNFVYHICECEPTWTTEAFVEEAIREVRAKVGNKRV
CCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEE
LLALSGGVDSSTLAFLLHKAIGDNLTCMFIDQGFMRKLEPERLIKLFRDQFHIPVEYVMA
EEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHCCHHHHHHHHHHHCCCCHHHHHH
RDRFLERLNGITDPEEKRKRIGHEFIQVFEEESRRLGPFDYLAQGTLYPDVIESADTNVD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCC
PATGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSLGLPEEIVNRHPFP
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
GPGLAIRIIGEVTAERLNILRDADLIVRQEVNRSGNYSEFWQAFAVLLPVRSVGVMGDQR
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TYAYPVVLRFVSSEDGMTADWSRAPYELLETISNRIVNEVKGVNRVAYDITSKPPGTIEW
CHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCC
E
C
>Mature Secondary Structure 
PSQTQQPLSAHPQDSTFAQTPVDRQMIVILDFGSQYSELIARRIRETQVYSEVLSYRTS
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
IEQLRQLNPKGIILSGGPNSVYAQHAPACDPEIWNLGIPVLGVCYGMQLMVQQLGGQVEA
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCC
SDAAEYGKASLIIDDPTDLLTNVEDQTTMWMSHGDSVTALPEGFKVLAHTANTPQAAVAH
CHHHHCCCEEEEEECCHHHHHCCCHHHEEEHCCCCCEEECCCCCEEEEECCCCCHHHHHH
HDRQLYGVQFHPEVVHSQGGQALICNFVYHICECEPTWTTEAFVEEAIREVRAKVGNKRV
CCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEE
LLALSGGVDSSTLAFLLHKAIGDNLTCMFIDQGFMRKLEPERLIKLFRDQFHIPVEYVMA
EEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHCCHHHHHHHHHHHCCCCHHHHHH
RDRFLERLNGITDPEEKRKRIGHEFIQVFEEESRRLGPFDYLAQGTLYPDVIESADTNVD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCC
PATGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVRKVGRSLGLPEEIVNRHPFP
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
GPGLAIRIIGEVTAERLNILRDADLIVRQEVNRSGNYSEFWQAFAVLLPVRSVGVMGDQR
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TYAYPVVLRFVSSEDGMTADWSRAPYELLETISNRIVNEVKGVNRVAYDITSKPPGTIEW
CHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA