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The map label for this gene is zam [H]

Identifier: 158337338

GI number: 158337338

Start: 4236937

End: 4239243

Strand: Reverse

Name: zam [H]

Synonym: AM1_4216

Alternate gene names: 158337338

Gene position: 4239243-4236937 (Counterclockwise)

Preceding gene: 158337339

Following gene: 158337337

Centisome position: 65.18

GC content: 50.46

Gene sequence:

>2307_bases
ATGGAATTTTCGATTAGTACTCTGCTGAACAACTTTGCAGATGATAAGTTACTCGCTCCAAAAGCTTTAGAAAAAAAATT
AGATTGCCAGGCTTCTGATGGCATCAGACAATTACAAATCACCTTAGAGGCCCTAGAAAAAGTCGGTATCCTCACCAAAG
AGCGCGGCAAATATAAGCGTCTCCCAGAAGAAGGGGTTGTTGAGGGAAAGCTCCGCTGCTCCAGTAAAGGCTTTTGCTTC
GCTATCCAAGATCAAGACGATACGGAAGATATTTATATTCGAGAGAGCCAGCTGAATACAGCTTGGAATGGTGATCGGGT
CCTGGTTAAAGTCACCAAGGAAGGTCGCCGTCGCCGTAGTCCCGAAGGTGAAGTCCGCCTCATCCTAGAACGCTCCAACC
CATCTGTGATTGCCAGGGTCAAGAAAACAGAAGCGGGGGAGTATCGAGCCGTCCCCCTCGATGATCGCCTTTTATTTGAA
CTCGCCCTCCATCAGGAAACCGATGGCCCCGACCTGGAAGCGGCGATTGATCAGCTTGTACATGTGGAGATTGTTCGCTA
CCCCTTAGGGCAGCTGTCCCCTCTAGGCCGGGTCACCCAAGTTCTAGGGAGTGATGCCCAATCGGCGGCTGATACAGAGC
TTGTCTTTTGTAAGTACGATTTGCCTCGCTCTTTTCCTGAAGATGTTTTAGCAGAAGCTGAAGCCCTGCCGAAAAAGCTG
CGCAAAGCCGATCAGAAAAAGCGGGTGAATCTGCTGAAGGTGCCCACGTTTACGATTTGCGATCGCACCCCCAATCCCAC
TCAACTCGACCATGCTTTTTCCGTCGAAAAATTAAAAGGCAGCAAGTGGCGCGTGGGCGTCCATGTCACTGACTTAGTCT
ACTATCTCGACCCAGACTCCTCCATCGAACGTCAGGCTAGCCAACGGGGGGCCGCTATGTTCCTCGGGGATACGGCACTG
CCCCTCTTCCCAGAAACCTGCATTGAGCGCATTGGTGCCCTCACCGCAGGCAAAGATCACCTCACGTTTTCCATCTTGGT
CACCTTGGATAACGAGGGGGAGGTTCTAGAATTTGAAATTCAGCCTTCTGTGATTCATGTCGATCAACACTTAGCCTATG
AACAAGTGCAAGAAATTCTGGATGGAGATCACAAAGATAAGTCCCTCGCAGATGCCATGCAGCTGTTTCAGACGGTGAGT
GAGGCCCTGAAAAAGCAACGCTATGATCGCGGTGGCTTTGATCTGTTGCTGTCCACCGTTCCTCCCCAAATCATGGGTGA
TGAAGGGGATTTAGGAGCCGTTATCTTAGCGTCCCCCACCCAAGCGCACAGCATCATTGCTGATCTGTTAGTCCTCGCCA
ATCACCTGGTTCTTTCCCATCTGCAGGCATTAGCCATTCCAGGGGTTTATCAAATCCAAGCTCCACCTGATGCTCAAGAT
CTCCAGGATCTACTCAAGTTGGCTGACAATATCCAGCTCTCCCTCGGTTTGCAGCAGGAAGATACGGTTCAGCCCCAGGA
TTTCCAAACCTTTAGCCAAACCTTTCAGACTTCAGAACGCTCAGCCATCCTATTTGAGCTACTGCAATCCACCCTCAAGC
CCGTCCAGTACAGTGCGGTGTCAGGGCCACATTTTGGTTTAGCCCTTGTCAACAACTATGGCCACTTCACCTCTCCCCTC
AATCGATATGGCGATTTGCTCAATCAGCGCATTTTACATGCGGTCTTTACAGAAGGGCGCGATCGGCGCACATCTCGAGC
CAAAGAGAAAGTGAATTTGCGCCATAGCGATTGCCATGGGCAGATTAGCTGGAATGTCTTACCCCCGGAGACCCAGCGGC
ATTTAGATGCCTTGATTACGGACGCGATTCCCCAATTGAATGAGCAAGCCGACTTAGCCCGTCAAGCCTGCCAGGATCTA
ACGGGGCTGCAAAAGACCAAGCAAATGCAAACTCATACGGGAGAAGTATTACAGGGTATTATCACCGGAATTCAGTCCTA
TGGTTTCTTTGTCCGCATCGAGACGCTCATGGTCGAAGGGTTAGTACATGTTAGCTCCCTCAAAGACGACTGGTATGAAT
ACCGCTCTCGCCAACAAACCTTAGTGGGTCGCAAAAATCGCTGTCAGTATCGTTTGGGTGATCGTGTTGATGTCGAGGTC
AAGAGCGTTGATTACTATCGCCAACAAATCGACTTAATTGTCGTCGGTGGTGGTAGCGAAGCTCCTGAAGATGAGGTGAC
CGAAGCGCCCATCAAAGTGAATGGTGAAGATGAGAGCGATCTCCCCGATGAGACAGAAGAGGAATAG

Upstream 100 bases:

>100_bases
CCAGGAGAACAGATGCTCCTGGCATTATGGCGAGAACGATCAACAAGGTTGGCACTGAGTTGGAGCCGGGCCCTAGCCAC
AATGAAGGACGAAAAGTTGC

Downstream 100 bases:

>100_bases
CTCCACCCCATGGATTGACCGAATGCCCCCACTCGATTGAGCAAGCGCTAACATGAATGCCCTAGAATTTTTCCAACTCA
GCGAAGGCCGGTGGCGGTCC

Product: acetazolamide conferring resistance protein

Products: tetrahydrofolate; N-formylmethionyl-tRNA(fMet)

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 768

Protein sequence:

>768_residues
MEFSISTLLNNFADDKLLAPKALEKKLDCQASDGIRQLQITLEALEKVGILTKERGKYKRLPEEGVVEGKLRCSSKGFCF
AIQDQDDTEDIYIRESQLNTAWNGDRVLVKVTKEGRRRRSPEGEVRLILERSNPSVIARVKKTEAGEYRAVPLDDRLLFE
LALHQETDGPDLEAAIDQLVHVEIVRYPLGQLSPLGRVTQVLGSDAQSAADTELVFCKYDLPRSFPEDVLAEAEALPKKL
RKADQKKRVNLLKVPTFTICDRTPNPTQLDHAFSVEKLKGSKWRVGVHVTDLVYYLDPDSSIERQASQRGAAMFLGDTAL
PLFPETCIERIGALTAGKDHLTFSILVTLDNEGEVLEFEIQPSVIHVDQHLAYEQVQEILDGDHKDKSLADAMQLFQTVS
EALKKQRYDRGGFDLLLSTVPPQIMGDEGDLGAVILASPTQAHSIIADLLVLANHLVLSHLQALAIPGVYQIQAPPDAQD
LQDLLKLADNIQLSLGLQQEDTVQPQDFQTFSQTFQTSERSAILFELLQSTLKPVQYSAVSGPHFGLALVNNYGHFTSPL
NRYGDLLNQRILHAVFTEGRDRRTSRAKEKVNLRHSDCHGQISWNVLPPETQRHLDALITDAIPQLNEQADLARQACQDL
TGLQKTKQMQTHTGEVLQGIITGIQSYGFFVRIETLMVEGLVHVSSLKDDWYEYRSRQQTLVGRKNRCQYRLGDRVDVEV
KSVDYYRQQIDLIVVGGGSEAPEDEVTEAPIKVNGEDESDLPDETEEE

Sequences:

>Translated_768_residues
MEFSISTLLNNFADDKLLAPKALEKKLDCQASDGIRQLQITLEALEKVGILTKERGKYKRLPEEGVVEGKLRCSSKGFCF
AIQDQDDTEDIYIRESQLNTAWNGDRVLVKVTKEGRRRRSPEGEVRLILERSNPSVIARVKKTEAGEYRAVPLDDRLLFE
LALHQETDGPDLEAAIDQLVHVEIVRYPLGQLSPLGRVTQVLGSDAQSAADTELVFCKYDLPRSFPEDVLAEAEALPKKL
RKADQKKRVNLLKVPTFTICDRTPNPTQLDHAFSVEKLKGSKWRVGVHVTDLVYYLDPDSSIERQASQRGAAMFLGDTAL
PLFPETCIERIGALTAGKDHLTFSILVTLDNEGEVLEFEIQPSVIHVDQHLAYEQVQEILDGDHKDKSLADAMQLFQTVS
EALKKQRYDRGGFDLLLSTVPPQIMGDEGDLGAVILASPTQAHSIIADLLVLANHLVLSHLQALAIPGVYQIQAPPDAQD
LQDLLKLADNIQLSLGLQQEDTVQPQDFQTFSQTFQTSERSAILFELLQSTLKPVQYSAVSGPHFGLALVNNYGHFTSPL
NRYGDLLNQRILHAVFTEGRDRRTSRAKEKVNLRHSDCHGQISWNVLPPETQRHLDALITDAIPQLNEQADLARQACQDL
TGLQKTKQMQTHTGEVLQGIITGIQSYGFFVRIETLMVEGLVHVSSLKDDWYEYRSRQQTLVGRKNRCQYRLGDRVDVEV
KSVDYYRQQIDLIVVGGGSEAPEDEVTEAPIKVNGEDESDLPDETEEE
>Mature_768_residues
MEFSISTLLNNFADDKLLAPKALEKKLDCQASDGIRQLQITLEALEKVGILTKERGKYKRLPEEGVVEGKLRCSSKGFCF
AIQDQDDTEDIYIRESQLNTAWNGDRVLVKVTKEGRRRRSPEGEVRLILERSNPSVIARVKKTEAGEYRAVPLDDRLLFE
LALHQETDGPDLEAAIDQLVHVEIVRYPLGQLSPLGRVTQVLGSDAQSAADTELVFCKYDLPRSFPEDVLAEAEALPKKL
RKADQKKRVNLLKVPTFTICDRTPNPTQLDHAFSVEKLKGSKWRVGVHVTDLVYYLDPDSSIERQASQRGAAMFLGDTAL
PLFPETCIERIGALTAGKDHLTFSILVTLDNEGEVLEFEIQPSVIHVDQHLAYEQVQEILDGDHKDKSLADAMQLFQTVS
EALKKQRYDRGGFDLLLSTVPPQIMGDEGDLGAVILASPTQAHSIIADLLVLANHLVLSHLQALAIPGVYQIQAPPDAQD
LQDLLKLADNIQLSLGLQQEDTVQPQDFQTFSQTFQTSERSAILFELLQSTLKPVQYSAVSGPHFGLALVNNYGHFTSPL
NRYGDLLNQRILHAVFTEGRDRRTSRAKEKVNLRHSDCHGQISWNVLPPETQRHLDALITDAIPQLNEQADLARQACQDL
TGLQKTKQMQTHTGEVLQGIITGIQSYGFFVRIETLMVEGLVHVSSLKDDWYEYRSRQQTLVGRKNRCQYRLGDRVDVEV
KSVDYYRQQIDLIVVGGGSEAPEDEVTEAPIKVNGEDESDLPDETEEE

Specific function: Not known; control resistance to the carbonic anhydrase inhibitor acetazolamide [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:
GO:0003676: Acetazolamide conferring resistance protein, putative
GO:0003723: Acetazolamide conferring resistance protein, putative
GO:0004518: Acetazolamide conferring resistance protein, putative
GO:0004527: Acetazolamide conferring resistance protein, putative
GO:0004540: Acetazolamide conferring resistance protein, putative
GO:0016787: Acetazolamide conferring resistance protein, putative

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=431, Percent_Identity=23.6658932714617, Blast_Score=120, Evalue=7e-27,
Organism=Homo sapiens, GI190014623, Length=466, Percent_Identity=22.7467811158798, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI190014625, Length=466, Percent_Identity=22.7467811158798, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI19115966, Length=434, Percent_Identity=23.0414746543779, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI219521928, Length=434, Percent_Identity=23.0414746543779, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI156105695, Length=212, Percent_Identity=27.8301886792453, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156105693, Length=212, Percent_Identity=27.8301886792453, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082383, Length=724, Percent_Identity=25.2762430939227, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1787542, Length=515, Percent_Identity=22.3300970873786, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI212645896, Length=443, Percent_Identity=23.9277652370203, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17553506, Length=445, Percent_Identity=23.8202247191011, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324552, Length=585, Percent_Identity=24.7863247863248, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24649634, Length=412, Percent_Identity=25, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI19922976, Length=367, Percent_Identity=22.6158038147139, Blast_Score=98, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24654597, Length=367, Percent_Identity=22.6158038147139, Blast_Score=98, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24654592, Length=367, Percent_Identity=22.6158038147139, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 2.1.2.9

Molecular weight: Translated: 86025; Mature: 86025

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSISTLLNNFADDKLLAPKALEKKLDCQASDGIRQLQITLEALEKVGILTKERGKYKR
CCEEHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHC
LPEEGVVEGKLRCSSKGFCFAIQDQDDTEDIYIRESQLNTAWNGDRVLVKVTKEGRRRRS
CCCCCCCCCEEEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHHCCC
PEGEVRLILERSNPSVIARVKKTEAGEYRAVPLDDRLLFELALHQETDGPDLEAAIDQLV
CCCCEEEEEECCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
HVEIVRYPLGQLSPLGRVTQVLGSDAQSAADTELVFCKYDLPRSFPEDVLAEAEALPKKL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
RKADQKKRVNLLKVPTFTICDRTPNPTQLDHAFSVEKLKGSKWRVGVHVTDLVYYLDPDS
HHHHHHHCCCEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCC
SIERQASQRGAAMFLGDTALPLFPETCIERIGALTAGKDHLTFSILVTLDNEGEVLEFEI
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEEE
QPSVIHVDQHLAYEQVQEILDGDHKDKSLADAMQLFQTVSEALKKQRYDRGGFDLLLSTV
CCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHC
PPQIMGDEGDLGAVILASPTQAHSIIADLLVLANHLVLSHLQALAIPGVYQIQAPPDAQD
CCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHH
LQDLLKLADNIQLSLGLQQEDTVQPQDFQTFSQTFQTSERSAILFELLQSTLKPVQYSAV
HHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECC
SGPHFGLALVNNYGHFTSPLNRYGDLLNQRILHAVFTEGRDRRTSRAKEKVNLRHSDCHG
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
QISWNVLPPETQRHLDALITDAIPQLNEQADLARQACQDLTGLQKTKQMQTHTGEVLQGI
EEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGIQSYGFFVRIETLMVEGLVHVSSLKDDWYEYRSRQQTLVGRKNRCQYRLGDRVDVEV
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEE
KSVDYYRQQIDLIVVGGGSEAPEDEVTEAPIKVNGEDESDLPDETEEE
HHHHHHHCEEEEEEECCCCCCCCCHHCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFSISTLLNNFADDKLLAPKALEKKLDCQASDGIRQLQITLEALEKVGILTKERGKYKR
CCEEHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHC
LPEEGVVEGKLRCSSKGFCFAIQDQDDTEDIYIRESQLNTAWNGDRVLVKVTKEGRRRRS
CCCCCCCCCEEEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHHCCC
PEGEVRLILERSNPSVIARVKKTEAGEYRAVPLDDRLLFELALHQETDGPDLEAAIDQLV
CCCCEEEEEECCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
HVEIVRYPLGQLSPLGRVTQVLGSDAQSAADTELVFCKYDLPRSFPEDVLAEAEALPKKL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
RKADQKKRVNLLKVPTFTICDRTPNPTQLDHAFSVEKLKGSKWRVGVHVTDLVYYLDPDS
HHHHHHHCCCEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCC
SIERQASQRGAAMFLGDTALPLFPETCIERIGALTAGKDHLTFSILVTLDNEGEVLEFEI
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEEEE
QPSVIHVDQHLAYEQVQEILDGDHKDKSLADAMQLFQTVSEALKKQRYDRGGFDLLLSTV
CCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHC
PPQIMGDEGDLGAVILASPTQAHSIIADLLVLANHLVLSHLQALAIPGVYQIQAPPDAQD
CCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHH
LQDLLKLADNIQLSLGLQQEDTVQPQDFQTFSQTFQTSERSAILFELLQSTLKPVQYSAV
HHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECC
SGPHFGLALVNNYGHFTSPLNRYGDLLNQRILHAVFTEGRDRRTSRAKEKVNLRHSDCHG
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
QISWNVLPPETQRHLDALITDAIPQLNEQADLARQACQDLTGLQKTKQMQTHTGEVLQGI
EEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITGIQSYGFFVRIETLMVEGLVHVSSLKDDWYEYRSRQQTLVGRKNRCQYRLGDRVDVEV
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEE
KSVDYYRQQIDLIVVGGGSEAPEDEVTEAPIKVNGEDESDLPDETEEE
HHHHHHHCEEEEEEECCCCCCCCCHHCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 10-formyltetrahydrofolate; L-methionyl-tRNA(fMet); H2O

Specific reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7727754; 8905231 [H]