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The map label for this gene is hisG

Identifier: 158337118

GI number: 158337118

Start: 4039991

End: 4040647

Strand: Direct

Name: hisG

Synonym: AM1_3992

Alternate gene names: 158337118

Gene position: 4039991-4040647 (Clockwise)

Preceding gene: 158337117

Following gene: 158337120

Centisome position: 62.12

GC content: 48.1

Gene sequence:

>657_bases
ATGCTCACGGTTGCCTTACCCAAAGGGGCGTTACTGAAAGATAGTATTCGCCTCCTCCAATCGGTTGGTTTGGATTTCAG
TGCCTTCTTAGACTCTGGGAATCGCCAACTGCAAATTCAAGACCCAACGCAAACCGCTCAAGGGTTATTGGTCAGGGCTC
AAGATGTCCCTGTTTACGTGGAGTATGGACAGGCGCAGCTTGGCATTGTCGGGTTTGATGTCTTACAAGAAAAGAAGCCC
CAGGTTGCTCAGTTTGCTGATCTTGGATTTGGCCATTGCCGAATGTCCGTGGCCGTTCCGAGTCAAAGCCCCTATCGTTC
AGCCATGGAACTACCCCCTAATTGTCGGGTAGCGTCTAAGTTTGTTCACTGTGCCCATGATTTTTTCTCCAAAATTGATT
TGCCCGTGGAAATTATTCCCCTCTACGGTTCTGTCGAATTGGGTCCGATTACAGGGATGTCGGAAGCGATTGTTGATCTC
GTCTCTACCGGACGCACCTTGAAAGAGAATGGTTTGATTGAGTTGGACTGTTTGTATGACAGTACGGCTCGTCTGATTGC
CCATCCCTTGAGTTATCGGCTGAATCAATACAACCTTGAGCATTGGCTAAATGAGATTAGTAAAAACAGCCAGCCCCTTG
CAGCTAAAGCATCCTAA

Upstream 100 bases:

>100_bases
ATTGCTTGGGTCAATGCCCAAGGGTCTGTCACAATTGAATCGCTAGCGTAATTCCCTTAGCGAACATTGCGATAGCCGTT
ATTCCATCGAGATTTATTTC

Downstream 100 bases:

>100_bases
AGGATAAAGATCACCCTTTAGGGAATCGGGACGGATGGATTAAAACGATAGCTTTGTAAAATTTCTCGGAAGGTCGATCG
GACTTGTTCAAAATCGGATC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYVEYGQAQLGIVGFDVLQEKKP
QVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASKFVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDL
VSTGRTLKENGLIELDCLYDSTARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS

Sequences:

>Translated_218_residues
MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYVEYGQAQLGIVGFDVLQEKKP
QVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASKFVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDL
VSTGRTLKENGLIELDCLYDSTARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS
>Mature_218_residues
MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYVEYGQAQLGIVGFDVLQEKKP
QVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASKFVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDL
VSTGRTLKENGLIELDCLYDSTARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=195, Percent_Identity=32.8205128205128, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ACAM1 (B0C9G3)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518293.1
- ProteinModelPortal:   B0C9G3
- SMR:   B0C9G3
- GeneID:   5682796
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3992
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   AMAR329726:AM1_3992-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23927; Mature: 23927

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYV
CEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHCCEEEEECCCEEEE
EYGQAQLGIVGFDVLQEKKPQVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASK
ECCCEEEEEEEHHHHHCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHH
FVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDLVSTGRTLKENGLIELDCLYD
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCCEEEEEECC
STARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYV
CEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHCCEEEEECCCEEEE
EYGQAQLGIVGFDVLQEKKPQVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASK
ECCCEEEEEEEHHHHHCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHH
FVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDLVSTGRTLKENGLIELDCLYD
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCCEEEEEECC
STARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA