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The map label for this gene is htpX

Identifier: 158337104

GI number: 158337104

Start: 4027290

End: 4028171

Strand: Direct

Name: htpX

Synonym: AM1_3977

Alternate gene names: 158337104

Gene position: 4027290-4028171 (Clockwise)

Preceding gene: 158337103

Following gene: 158337106

Centisome position: 61.92

GC content: 51.93

Gene sequence:

>882_bases
ATGAATCAACTCAAAACCGCCAGTTTACTAGGTCTACTCAGTGCTCTCCTCATTGGAAGTAGTTATGCTCTTTTAGGGGG
CAGTGGCGGCATGGTCATGGGTATTGGTCTCGCCGCATTGACTAACTTAGGAGCTTGGTATTACTCTGACCAGATTGCCT
TATCGGCCTACCAGGCGCAGTTGGTGCGGCCCAATCAAGCCCCTCATCTGTACGCTGTAGTTCAGCGTTTGGCCCAGCGA
GCAAACTTACCTATGCCACGCTTGTATATCATTCCCAGTTCAGCTGCGAATGCCTTTGCAACGGGGCGTGATCCCGACCA
TGCGGCCATTGCTGTTACGGAAGGGTTGCTGAGGATGCTGCCAGCGGCAGAACTAGAAGGGGTTCTTGCCCATGAGTTGG
CTCATATCCAGAATCGGGACACTTTGACCCAAGCAGTTGCTGCTACGTTAGCCGGTGCGATCGCATTCTTAGCCCAAATG
GTGAGCTACAGTTTCTGGTTTTTCGGCAGTCGAGGCAATGATCGAGAATCCAACCCTATCGGTGCTTTATTGATGATTGT
CTTGGCACCCCTGTCAGCAACGATCCTGCAATTAGGGATCTCTCGGACCCGCGAGTTCTCTGCAGACGAAACTGCTGCTC
GCCTAACGGGGCAACCTCGCGCCCTAGCCCAAGCCTTGTCTCGTTTGGAAAGCAATGCTCAGCGGAATGCGTTAGGGGGC
AATCCGGCGTTTGCACCGCTGTTGATTATTAATCCCCCAGTTCGGCAATGGCTAAGTAACTTGTTTACGACTCATCCCAG
TACGCAAGATCGTATCAATCGTTTACTCAAGCTAGAGCAGCAACTGCAAAGACGCCCATCTATTGCGTTCACATCGCTTT
AA

Upstream 100 bases:

>100_bases
ATAGGGTAAACCCTGCATCATCAGGGGGGCTTCCTACCCATATTGCGCCACGAGAACTTTTTAAACTGGGGTTAATCGTG
CATGTCTGTGGAGGCCAGCG

Downstream 100 bases:

>100_bases
CAGAAGACTCTTCTTCGGAGTGGTTAAAATCGCCACTCTGAAGAAGAGTCTTACCCTGGCCCTAAGCCTACTGCGCCAGC
ATAGGACGCTTGACTGCCGA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNQLKTASLLGLLSALLIGSSYALLGGSGGMVMGIGLAALTNLGAWYYSDQIALSAYQAQLVRPNQAPHLYAVVQRLAQR
ANLPMPRLYIIPSSAANAFATGRDPDHAAIAVTEGLLRMLPAAELEGVLAHELAHIQNRDTLTQAVAATLAGAIAFLAQM
VSYSFWFFGSRGNDRESNPIGALLMIVLAPLSATILQLGISRTREFSADETAARLTGQPRALAQALSRLESNAQRNALGG
NPAFAPLLIINPPVRQWLSNLFTTHPSTQDRINRLLKLEQQLQRRPSIAFTSL

Sequences:

>Translated_293_residues
MNQLKTASLLGLLSALLIGSSYALLGGSGGMVMGIGLAALTNLGAWYYSDQIALSAYQAQLVRPNQAPHLYAVVQRLAQR
ANLPMPRLYIIPSSAANAFATGRDPDHAAIAVTEGLLRMLPAAELEGVLAHELAHIQNRDTLTQAVAATLAGAIAFLAQM
VSYSFWFFGSRGNDRESNPIGALLMIVLAPLSATILQLGISRTREFSADETAARLTGQPRALAQALSRLESNAQRNALGG
NPAFAPLLIINPPVRQWLSNLFTTHPSTQDRINRLLKLEQQLQRRPSIAFTSL
>Mature_293_residues
MNQLKTASLLGLLSALLIGSSYALLGGSGGMVMGIGLAALTNLGAWYYSDQIALSAYQAQLVRPNQAPHLYAVVQRLAQR
ANLPMPRLYIIPSSAANAFATGRDPDHAAIAVTEGLLRMLPAAELEGVLAHELAHIQNRDTLTQAVAATLAGAIAFLAQM
VSYSFWFFGSRGNDRESNPIGALLMIVLAPLSATILQLGISRTREFSADETAARLTGQPRALAQALSRLESNAQRNALGG
NPAFAPLLIINPPVRQWLSNLFTTHPSTQDRINRLLKLEQQLQRRPSIAFTSL

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=210, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ACAM1 (B0C9E9)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518279.1
- ProteinModelPortal:   B0C9E9
- MEROPS:   M48.004
- GeneID:   5682781
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3977
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03982
- BioCyc:   AMAR329726:AM1_3977-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31474; Mature: 31474

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

HASH(0x12352b74)-; HASH(0x12e04ec4)-; HASH(0x10ec63c0)-; HASH(0x12e09c0c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLKTASLLGLLSALLIGSSYALLGGSGGMVMGIGLAALTNLGAWYYSDQIALSAYQAQ
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHH
LVRPNQAPHLYAVVQRLAQRANLPMPRLYIIPSSAANAFATGRDPDHAAIAVTEGLLRML
HCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
PAAELEGVLAHELAHIQNRDTLTQAVAATLAGAIAFLAQMVSYSFWFFGSRGNDRESNPI
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHH
GALLMIVLAPLSATILQLGISRTREFSADETAARLTGQPRALAQALSRLESNAQRNALGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
NPAFAPLLIINPPVRQWLSNLFTTHPSTQDRINRLLKLEQQLQRRPSIAFTSL
CCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MNQLKTASLLGLLSALLIGSSYALLGGSGGMVMGIGLAALTNLGAWYYSDQIALSAYQAQ
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHH
LVRPNQAPHLYAVVQRLAQRANLPMPRLYIIPSSAANAFATGRDPDHAAIAVTEGLLRML
HCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
PAAELEGVLAHELAHIQNRDTLTQAVAATLAGAIAFLAQMVSYSFWFFGSRGNDRESNPI
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHH
GALLMIVLAPLSATILQLGISRTREFSADETAARLTGQPRALAQALSRLESNAQRNALGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
NPAFAPLLIINPPVRQWLSNLFTTHPSTQDRINRLLKLEQQLQRRPSIAFTSL
CCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA