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The map label for this gene is hemC [H]

Identifier: 158337071

GI number: 158337071

Start: 3993012

End: 3993956

Strand: Reverse

Name: hemC [H]

Synonym: AM1_3944

Alternate gene names: 158337071

Gene position: 3993956-3993012 (Counterclockwise)

Preceding gene: 158337072

Following gene: 158337070

Centisome position: 61.41

GC content: 49.1

Gene sequence:

>945_bases
GTGATTCGGATTGGTTCCCGTAAAAGTCAACTAGCCCTAGTGCAGACGCACTGGGTCCAAGGAGAATTACAAAAACATTT
TCCAGAGTACGAATTTGAAGTTTGCACCATGTCCACACAAGGGGACAATATCCTCGATGTTGCTCTGGCCAAGATTGGAG
ACAAGGGATTATTTACGAAGGAGCTAGAGGTATCAATGCTCCGTAAAGAGACGGATTTGGCAGTGCATTCCCTCAAAGAT
CTACCGACGAACCTACCGGAAGGTCTGTGCCTAGGCGTTGTGACAGAGCGGGTTGATCCTGCGGATGCCCTAGTCGTCCA
TGAAAATTTTAAAGCGTATCAGCTAGATACCCTCCCGGAAGGAGCGGTCATTGGTACGTCATCCCTCCGGCGGCTCGCTC
AACTCCGTTATAACTATCCCCATTTAGAATTCAAAGATATTCGCGGCAACTTAAATACCCGCCTTCAGAAGCTAGATGAG
GGTGAATATGATGGCATCATTCTGGCTGTTGCTGGATTGCAACGACTCGGCTTTGGTGATCGAATCCATCAGGTGATCCC
TGCAAACATTTCGTTACATGCCGTCGGCCAGGGTGCATTAGGCATTGAATGCCGCGAAGGAGATGAAGAAATTATGGCCT
TTATCAAGGCCTTAGAGCATGAACCCTCAGCCCATCGCTGTACAGCTGAACGCTCCTTTCTGCATGAATTGGAAGGTGGC
TGTCAAGTTCCTATTGGCGTAAATACGAGTCTTAAGGAAGGCCAGTTAACCCTCGTAGGTATGGTGGCCAGTTTAGACGG
CAAACGCTTGATTAAAGACACCGTTTCAGGGCCCATTGCTAGTGCCACCCAACTCGGGATTGATCTCGCCCAAAAAGTGC
GGGAACAAGGAGCCCAAGAAATTCTAGAGGAAATATTCGCCGCTGCTCGTCCCTCAGATCTCTGA

Upstream 100 bases:

>100_bases
CTTTCGAGTGCTCCCGCAATTCTGTAAGCTGTTGAGGTACGTTCATCTTTACCGCTGCAATTAACAGCGACTTGATTCTA
TGTCTGCCTCCAGCCCTCGC

Downstream 100 bases:

>100_bases
TAGTCTGATAGCACCCACTTTTTGGATCGACCTGGCTAGTCTCTGAAATCGCTGTCGGTTGTCATCACAACAGGGTAGGT
TTCTTCACTATCCAGATCGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIRIGSRKSQLALVQTHWVQGELQKHFPEYEFEVCTMSTQGDNILDVALAKIGDKGLFTKELEVSMLRKETDLAVHSLKD
LPTNLPEGLCLGVVTERVDPADALVVHENFKAYQLDTLPEGAVIGTSSLRRLAQLRYNYPHLEFKDIRGNLNTRLQKLDE
GEYDGIILAVAGLQRLGFGDRIHQVIPANISLHAVGQGALGIECREGDEEIMAFIKALEHEPSAHRCTAERSFLHELEGG
CQVPIGVNTSLKEGQLTLVGMVASLDGKRLIKDTVSGPIASATQLGIDLAQKVREQGAQEILEEIFAAARPSDL

Sequences:

>Translated_314_residues
MIRIGSRKSQLALVQTHWVQGELQKHFPEYEFEVCTMSTQGDNILDVALAKIGDKGLFTKELEVSMLRKETDLAVHSLKD
LPTNLPEGLCLGVVTERVDPADALVVHENFKAYQLDTLPEGAVIGTSSLRRLAQLRYNYPHLEFKDIRGNLNTRLQKLDE
GEYDGIILAVAGLQRLGFGDRIHQVIPANISLHAVGQGALGIECREGDEEIMAFIKALEHEPSAHRCTAERSFLHELEGG
CQVPIGVNTSLKEGQLTLVGMVASLDGKRLIKDTVSGPIASATQLGIDLAQKVREQGAQEILEEIFAAARPSDL
>Mature_314_residues
MIRIGSRKSQLALVQTHWVQGELQKHFPEYEFEVCTMSTQGDNILDVALAKIGDKGLFTKELEVSMLRKETDLAVHSLKD
LPTNLPEGLCLGVVTERVDPADALVVHENFKAYQLDTLPEGAVIGTSSLRRLAQLRYNYPHLEFKDIRGNLNTRLQKLDE
GEYDGIILAVAGLQRLGFGDRIHQVIPANISLHAVGQGALGIECREGDEEIMAFIKALEHEPSAHRCTAERSFLHELEGG
CQVPIGVNTSLKEGQLTLVGMVASLDGKRLIKDTVSGPIASATQLGIDLAQKVREQGAQEILEEIFAAARPSDL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:
GO:0004418: Porphobilinogen deaminase
GO:0006779: Porphobilinogen deaminase
GO:0015995: Porphobilinogen deaminase
GO:0016740: Porphobilinogen deaminase
GO:0018160: Porphobilinogen deaminase
GO:0033014: Porphobilinogen deaminase

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=48.3483483483483, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=48.3483483483483, Blast_Score=305, Evalue=3e-83,
Organism=Escherichia coli, GI48994974, Length=312, Percent_Identity=48.7179487179487, Blast_Score=287, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=43.8485804416404, Blast_Score=243, Evalue=2e-65,
Organism=Drosophila melanogaster, GI20130425, Length=316, Percent_Identity=49.0506329113924, Blast_Score=280, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34450; Mature: 34450

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIGSRKSQLALVQTHWVQGELQKHFPEYEFEVCTMSTQGDNILDVALAKIGDKGLFTK
CCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHH
ELEVSMLRKETDLAVHSLKDLPTNLPEGLCLGVVTERVDPADALVVHENFKAYQLDTLPE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCC
GAVIGTSSLRRLAQLRYNYPHLEFKDIRGNLNTRLQKLDEGEYDGIILAVAGLQRLGFGD
CCEECHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCH
RIHQVIPANISLHAVGQGALGIECREGDEEIMAFIKALEHEPSAHRCTAERSFLHELEGG
HHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
CQVPIGVNTSLKEGQLTLVGMVASLDGKRLIKDTVSGPIASATQLGIDLAQKVREQGAQE
CEEEECCCCCCCCCCEEEEEEEHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ILEEIFAAARPSDL
HHHHHHHHCCCCCC
>Mature Secondary Structure
MIRIGSRKSQLALVQTHWVQGELQKHFPEYEFEVCTMSTQGDNILDVALAKIGDKGLFTK
CCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHH
ELEVSMLRKETDLAVHSLKDLPTNLPEGLCLGVVTERVDPADALVVHENFKAYQLDTLPE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCC
GAVIGTSSLRRLAQLRYNYPHLEFKDIRGNLNTRLQKLDEGEYDGIILAVAGLQRLGFGD
CCEECHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCH
RIHQVIPANISLHAVGQGALGIECREGDEEIMAFIKALEHEPSAHRCTAERSFLHELEGG
HHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
CQVPIGVNTSLKEGQLTLVGMVASLDGKRLIKDTVSGPIASATQLGIDLAQKVREQGAQE
CEEEECCCCCCCCCCEEEEEEEHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ILEEIFAAARPSDL
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA