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The map label for this gene is menC [H]

Identifier: 158336885

GI number: 158336885

Start: 3812521

End: 3813444

Strand: Direct

Name: menC [H]

Synonym: AM1_3753

Alternate gene names: 158336885

Gene position: 3812521-3813444 (Clockwise)

Preceding gene: 158336882

Following gene: 158336886

Centisome position: 58.62

GC content: 49.57

Gene sequence:

>924_bases
ATGGAATTTTCCTATCAAACCTATCAACGATCGTTCCAACAGCCCTTACAAACAAGATATGGGCCGTGGTCGATCCGTCG
AGGGTTGATGGTTATGTTAGAGGATGATGCTGGCAATATTGGCCAAGGTGAAATTGCTCCTTTATCGTGGTTTGGATCTG
AAACTTGGGAACAGGCCCAGACCTATTGTCAGCAACTACCTCGACAGCTAACGGACGCTCACATCTTGTCTATCCCAGAT
CGCTATCCGGCTTGCCAGTTTGGATTGGGTTCAGCGTGGGAAGCATTACATCAAAATTCCGTATCAGCGTCTGTTTTCCC
TGAGATTTGCGGCCTATTACCCACCGGAAGCTCCGCTTTGTCCGCCGCTTCCAAGCTATGGGAGCAGGGCTATCGAACTT
TTAAGTGGAAAATTGGGGTGGATGCCATCGAACAGGAACAGGCTATTTTTCGGCGGTTGATCGTAGCTTTGCCACCGCAA
GCCTTGCTGCGCTTGGATGCCAATGGAGGACTAACCAATGAGTCTGCTTGTCGTTGGCTGCAGCTGTGTGATCAGGTGAT
GGACACTCTTAGGATTGAATATCTGGAGCAACCGCTCCCCCCCGAGCAATTGTCGGCCATGTTGTCCTTAAGTCAGCAGT
TTCAAACCCCATTGGCTTTAGATGAGTCGGTAGCAACTCTGTCTCAGCTACAACACTGTGTTCAACAAGGATGGAACGGC
ATTTTCGTGATTAAACCTGCTATTTGTGGTTATCCCCACCGCTTACGTCAGTTTTGCCAATCCCATCCGATTGATGCTGT
TTTCTCCTCTGTCTTTGAATCAGAGGTGGGGCGGCAGGCCTGTCTGAGATTGGCGGCAGAACTATCGAATCCCCAACGAG
CCATTGGGTTTGGTGTTTGCCATTGGTTGTCCCCTGATGAATAA

Upstream 100 bases:

>100_bases
ACAATAGAAGCTCCCTCTAGAATGTGCAGTGATCAGTTTTGATCTGTTATGTGATTTAAAACAATGCCGTATACGGGGTG
AAGCGATCAGCGTCAAGAAC

Downstream 100 bases:

>100_bases
CGCTTCGTTCTCGGTTGATCCGGTTAAGCCGTCCAGTGCTCACTTATTGGGTTCTCCCCAAGCAATTTGGCACAGGGAAG
ACTGGATTCTGGGCCTTAAT

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MEFSYQTYQRSFQQPLQTRYGPWSIRRGLMVMLEDDAGNIGQGEIAPLSWFGSETWEQAQTYCQQLPRQLTDAHILSIPD
RYPACQFGLGSAWEALHQNSVSASVFPEICGLLPTGSSALSAASKLWEQGYRTFKWKIGVDAIEQEQAIFRRLIVALPPQ
ALLRLDANGGLTNESACRWLQLCDQVMDTLRIEYLEQPLPPEQLSAMLSLSQQFQTPLALDESVATLSQLQHCVQQGWNG
IFVIKPAICGYPHRLRQFCQSHPIDAVFSSVFESEVGRQACLRLAAELSNPQRAIGFGVCHWLSPDE

Sequences:

>Translated_307_residues
MEFSYQTYQRSFQQPLQTRYGPWSIRRGLMVMLEDDAGNIGQGEIAPLSWFGSETWEQAQTYCQQLPRQLTDAHILSIPD
RYPACQFGLGSAWEALHQNSVSASVFPEICGLLPTGSSALSAASKLWEQGYRTFKWKIGVDAIEQEQAIFRRLIVALPPQ
ALLRLDANGGLTNESACRWLQLCDQVMDTLRIEYLEQPLPPEQLSAMLSLSQQFQTPLALDESVATLSQLQHCVQQGWNG
IFVIKPAICGYPHRLRQFCQSHPIDAVFSSVFESEVGRQACLRLAAELSNPQRAIGFGVCHWLSPDE
>Mature_307_residues
MEFSYQTYQRSFQQPLQTRYGPWSIRRGLMVMLEDDAGNIGQGEIAPLSWFGSETWEQAQTYCQQLPRQLTDAHILSIPD
RYPACQFGLGSAWEALHQNSVSASVFPEICGLLPTGSSALSAASKLWEQGYRTFKWKIGVDAIEQEQAIFRRLIVALPPQ
ALLRLDANGGLTNESACRWLQLCDQVMDTLRIEYLEQPLPPEQLSAMLSLSQQFQTPLALDESVATLSQLQHCVQQGWNG
IFVIKPAICGYPHRLRQFCQSHPIDAVFSSVFESEVGRQACLRLAAELSNPQRAIGFGVCHWLSPDE

Specific function: Converts SHCHC to OSB [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:
GO:0000287: O-succinylbenzoic acid (OSB) synthetase
GO:0003824: O-succinylbenzoic acid (OSB) synthetase
GO:0004871: O-succinylbenzoic acid (OSB) synthetase
GO:0007165: O-succinylbenzoic acid (OSB) synthetase
GO:0008152: O-succinylbenzoic acid (OSB) synthetase
GO:0009234: O-succinylbenzoic acid (OSB) synthetase
GO:0016829: O-succinylbenzoic acid (OSB) synthetase
GO:0016836: O-succinylbenzoic acid (OSB) synthetase
GO:0046872: O-succinylbenzoic acid (OSB) synthetase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR001354
- InterPro:   IPR010196 [H]

Pfam domain/function: PF01188 MR_MLE [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 34479; Mature: 34479

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSYQTYQRSFQQPLQTRYGPWSIRRGLMVMLEDDAGNIGQGEIAPLSWFGSETWEQAQ
CCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHH
TYCQQLPRQLTDAHILSIPDRYPACQFGLGSAWEALHQNSVSASVFPEICGLLPTGSSAL
HHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
SAASKLWEQGYRTFKWKIGVDAIEQEQAIFRRLIVALPPQALLRLDANGGLTNESACRWL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCCHHHHHHH
QLCDQVMDTLRIEYLEQPLPPEQLSAMLSLSQQFQTPLALDESVATLSQLQHCVQQGWNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
IFVIKPAICGYPHRLRQFCQSHPIDAVFSSVFESEVGRQACLRLAAELSNPQRAIGFGVC
EEEECCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HWLSPDE
CCCCCCC
>Mature Secondary Structure
MEFSYQTYQRSFQQPLQTRYGPWSIRRGLMVMLEDDAGNIGQGEIAPLSWFGSETWEQAQ
CCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHH
TYCQQLPRQLTDAHILSIPDRYPACQFGLGSAWEALHQNSVSASVFPEICGLLPTGSSAL
HHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
SAASKLWEQGYRTFKWKIGVDAIEQEQAIFRRLIVALPPQALLRLDANGGLTNESACRWL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCCHHHHHHH
QLCDQVMDTLRIEYLEQPLPPEQLSAMLSLSQQFQTPLALDESVATLSQLQHCVQQGWNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
IFVIKPAICGYPHRLRQFCQSHPIDAVFSSVFESEVGRQACLRLAAELSNPQRAIGFGVC
EEEECCHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HWLSPDE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]