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The map label for this gene is pkn1 [H]

Identifier: 158336870

GI number: 158336870

Start: 3791348

End: 3792967

Strand: Direct

Name: pkn1 [H]

Synonym: AM1_3738

Alternate gene names: 158336870

Gene position: 3791348-3792967 (Clockwise)

Preceding gene: 158336869

Following gene: 158336876

Centisome position: 58.3

GC content: 53.95

Gene sequence:

>1620_bases
ATGGGCATCAAGCGTCGACAGTTTTTGTGGTTCGGGGGGACTGCTGTAATCAGCTTGGCCTCGTCCCAATGGTCTTTCGC
CAAATCAGTTCGGGATATTCGCCAAATTGCCCGTCACATTACCGTTCGCATTATGACCCAAGGCCCTTCTGGCTCCGGGG
TGTTAATCAAGCGAAATGACAATATCTACACCGTACTGACGGCGGCCCATGTGATCAAAAACTCCAACCGGGGTGAGGAA
GCCTATGTGGAAACCTATGACGGTGAAACCCATCTCCTCAATACCCAAATGATGCAGGTGGATGTCAAAGCGGATATTGC
GATCGCAACCTTCACTTCCAGCAACAACTATCGCACCACCAACATTGGCAAGTTTAAAGACCTGGGCATTTTGGATGACA
TTTATGTCGGTGGTTATCCCCTAGCCGATCAGGCCATTTCCGTCTCCACCATGACCCTAACTCGGGGCGAAGTGGCCTCC
ATTGGTGAATTTGAGGATGGCTATGGGTTTTCCTACACGGCCGTCACCAAGGCAGGCATGAGCGGTGGCCCAGTGTTAGA
TCGCGAAGGTCGCCTAATTGGGATTCATGGTCGGGCGGCGGGACAGCGCTTACAAGACGTGCGGATTAAAGATGGTTTGA
ATTTAGGGATTCCGATCTCAACTGCGATCGCAACCTTTGGTCTCGACAATCAGTACCGGCCCCTGACCGCTGAGCAACCG
GATACATCTGAACCCCAGACCTCTGAACCCTCTGAACCGGAGTCCACCCAAGCGCCACCGGAGGAGACTCTGCCCGGCCT
CTCTCGGTTTGCCTTTGAAGTGGTGGCAGTGAATGCCCAAGGTCAAATCCAAACCCGCAGCCGTCAGTCTGCCCAATATT
ATCGCCAGCAGCTAAAACAAGATCAGACCCTGGATATGGTCTATATCCCTGGGGGAAAATTTAGTATGGGCTCTCCGGCA
ACGGAAGCCAATCGTCAAGGCAGTGAAGGTCCCCAACACCTGGTCACAGTTCCCACCTTTTTTATTGGCAAATATCCGAT
TACCCAAGCCCAATGGCAGGCCGTGATGGGGGAGAATCCGGCCAAGTTTCAGGGGGCAGATCGTCCCGTCGAGCAAGTGA
GCTGGCAGGCCGCGACGGAGTTTTGCCAAAAACTATCGGAACTCACGGGCCAGGACTATCGTTTACCCAGCGAAGCAGAA
TGGGAATATGCTGCTCGTGCCGGGACTAGCGCACCCTTCTGTGTGGGGGCTACCCTGACCACGGACTTAGCCAACTACGA
CGGCAACTATACCTATGGTCGCGGTCCGCGGGGCACCTTTCGCAAGGCCACAACTCCCGTTGGTCAATTTTCACCCAACC
CCTTTGGTCTTTATGACATGCATGGCCAGGTCTGGGAATGGTGTCAAGATCATTGGCATGACACCTACAAAGGGGCACCT
GCGGATGGATCGGCCTGGGTGAAGGATACGGATGTGCGATCGCACCGAGTCAGACGAGGAGGATCTTGGTACGACGGTCC
CCATGCCTGCCGGTCCGCCTTTCGCTATCGGTCATTACCGAGTAACTATCAAAACTCCTATGGCCTGAGAGTGGTCTGCC
AAGAGTTTAAGGATATTTAG

Upstream 100 bases:

>100_bases
AATGCGCTAATATCCGTATCACCCTTCTAATCCGAGACATTCCCAAATAGAGCGGATACAGTAGGAATAAGGGTTTTGCA
GCGTATTGATATAGGTTGGA

Downstream 100 bases:

>100_bases
CAGCCCAGATGGCCCCAAAGAACTAACCCACTAACTCCGGGGTCTTCTGGTCAATCAATCCTGCTAGGGTATCGAGTAAC
TCCTGCTCGTTAAAGGGCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MGIKRRQFLWFGGTAVISLASSQWSFAKSVRDIRQIARHITVRIMTQGPSGSGVLIKRNDNIYTVLTAAHVIKNSNRGEE
AYVETYDGETHLLNTQMMQVDVKADIAIATFTSSNNYRTTNIGKFKDLGILDDIYVGGYPLADQAISVSTMTLTRGEVAS
IGEFEDGYGFSYTAVTKAGMSGGPVLDREGRLIGIHGRAAGQRLQDVRIKDGLNLGIPISTAIATFGLDNQYRPLTAEQP
DTSEPQTSEPSEPESTQAPPEETLPGLSRFAFEVVAVNAQGQIQTRSRQSAQYYRQQLKQDQTLDMVYIPGGKFSMGSPA
TEANRQGSEGPQHLVTVPTFFIGKYPITQAQWQAVMGENPAKFQGADRPVEQVSWQAATEFCQKLSELTGQDYRLPSEAE
WEYAARAGTSAPFCVGATLTTDLANYDGNYTYGRGPRGTFRKATTPVGQFSPNPFGLYDMHGQVWEWCQDHWHDTYKGAP
ADGSAWVKDTDVRSHRVRRGGSWYDGPHACRSAFRYRSLPSNYQNSYGLRVVCQEFKDI

Sequences:

>Translated_539_residues
MGIKRRQFLWFGGTAVISLASSQWSFAKSVRDIRQIARHITVRIMTQGPSGSGVLIKRNDNIYTVLTAAHVIKNSNRGEE
AYVETYDGETHLLNTQMMQVDVKADIAIATFTSSNNYRTTNIGKFKDLGILDDIYVGGYPLADQAISVSTMTLTRGEVAS
IGEFEDGYGFSYTAVTKAGMSGGPVLDREGRLIGIHGRAAGQRLQDVRIKDGLNLGIPISTAIATFGLDNQYRPLTAEQP
DTSEPQTSEPSEPESTQAPPEETLPGLSRFAFEVVAVNAQGQIQTRSRQSAQYYRQQLKQDQTLDMVYIPGGKFSMGSPA
TEANRQGSEGPQHLVTVPTFFIGKYPITQAQWQAVMGENPAKFQGADRPVEQVSWQAATEFCQKLSELTGQDYRLPSEAE
WEYAARAGTSAPFCVGATLTTDLANYDGNYTYGRGPRGTFRKATTPVGQFSPNPFGLYDMHGQVWEWCQDHWHDTYKGAP
ADGSAWVKDTDVRSHRVRRGGSWYDGPHACRSAFRYRSLPSNYQNSYGLRVVCQEFKDI
>Mature_538_residues
GIKRRQFLWFGGTAVISLASSQWSFAKSVRDIRQIARHITVRIMTQGPSGSGVLIKRNDNIYTVLTAAHVIKNSNRGEEA
YVETYDGETHLLNTQMMQVDVKADIAIATFTSSNNYRTTNIGKFKDLGILDDIYVGGYPLADQAISVSTMTLTRGEVASI
GEFEDGYGFSYTAVTKAGMSGGPVLDREGRLIGIHGRAAGQRLQDVRIKDGLNLGIPISTAIATFGLDNQYRPLTAEQPD
TSEPQTSEPSEPESTQAPPEETLPGLSRFAFEVVAVNAQGQIQTRSRQSAQYYRQQLKQDQTLDMVYIPGGKFSMGSPAT
EANRQGSEGPQHLVTVPTFFIGKYPITQAQWQAVMGENPAKFQGADRPVEQVSWQAATEFCQKLSELTGQDYRLPSEAEW
EYAARAGTSAPFCVGATLTTDLANYDGNYTYGRGPRGTFRKATTPVGQFSPNPFGLYDMHGQVWEWCQDHWHDTYKGAPA
DGSAWVKDTDVRSHRVRRGGSWYDGPHACRSAFRYRSLPSNYQNSYGLRVVCQEFKDI

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=265, Percent_Identity=28.6792452830189, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI38202250, Length=290, Percent_Identity=26.2068965517241, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI257470977, Length=224, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194248088, Length=297, Percent_Identity=25.2525252525253, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20130397, Length=313, Percent_Identity=26.8370607028754, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 59612; Mature: 59481

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKRRQFLWFGGTAVISLASSQWSFAKSVRDIRQIARHITVRIMTQGPSGSGVLIKRND
CCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECC
NIYTVLTAAHVIKNSNRGEEAYVETYDGETHLLNTQMMQVDVKADIAIATFTSSNNYRTT
CEEEEEEHHHHHHCCCCCCEEEEEEECCCEEEEECEEEEEEEEEEEEEEEEECCCCEEEC
NIGKFKDLGILDDIYVGGYPLADQAISVSTMTLTRGEVASIGEFEDGYGFSYTAVTKAGM
CCCCCCCCCCCHHHEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEHHHHCCC
SGGPVLDREGRLIGIHGRAAGQRLQDVRIKDGLNLGIPISTAIATFGLDNQYRPLTAEQP
CCCCEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
DTSEPQTSEPSEPESTQAPPEETLPGLSRFAFEVVAVNAQGQIQTRSRQSAQYYRQQLKQ
CCCCCCCCCCCCCCCCCCCCHHHCCHHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHCC
DQTLDMVYIPGGKFSMGSPATEANRQGSEGPQHLVTVPTFFIGKYPITQAQWQAVMGENP
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCHHHHHHHHCCCC
AKFQGADRPVEQVSWQAATEFCQKLSELTGQDYRLPSEAEWEYAARAGTSAPFCVGATLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCEEECCCHH
TDLANYDGNYTYGRGPRGTFRKATTPVGQFSPNPFGLYDMHGQVWEWCQDHWHDTYKGAP
HHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHCCCCC
ADGSAWVKDTDVRSHRVRRGGSWYDGPHACRSAFRYRSLPSNYQNSYGLRVVCQEFKDI
CCCCCCEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GIKRRQFLWFGGTAVISLASSQWSFAKSVRDIRQIARHITVRIMTQGPSGSGVLIKRND
CCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECC
NIYTVLTAAHVIKNSNRGEEAYVETYDGETHLLNTQMMQVDVKADIAIATFTSSNNYRTT
CEEEEEEHHHHHHCCCCCCEEEEEEECCCEEEEECEEEEEEEEEEEEEEEEECCCCEEEC
NIGKFKDLGILDDIYVGGYPLADQAISVSTMTLTRGEVASIGEFEDGYGFSYTAVTKAGM
CCCCCCCCCCCHHHEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEHHHHCCC
SGGPVLDREGRLIGIHGRAAGQRLQDVRIKDGLNLGIPISTAIATFGLDNQYRPLTAEQP
CCCCEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
DTSEPQTSEPSEPESTQAPPEETLPGLSRFAFEVVAVNAQGQIQTRSRQSAQYYRQQLKQ
CCCCCCCCCCCCCCCCCCCCHHHCCHHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHCC
DQTLDMVYIPGGKFSMGSPATEANRQGSEGPQHLVTVPTFFIGKYPITQAQWQAVMGENP
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCHHHHHHHHCCCC
AKFQGADRPVEQVSWQAATEFCQKLSELTGQDYRLPSEAEWEYAARAGTSAPFCVGATLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCEEECCCHH
TDLANYDGNYTYGRGPRGTFRKATTPVGQFSPNPFGLYDMHGQVWEWCQDHWHDTYKGAP
HHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHCCCCC
ADGSAWVKDTDVRSHRVRRGGSWYDGPHACRSAFRYRSLPSNYQNSYGLRVVCQEFKDI
CCCCCCEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]