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The map label for this gene is pip [H]

Identifier: 158336727

GI number: 158336727

Start: 3650602

End: 3651459

Strand: Direct

Name: pip [H]

Synonym: AM1_3595

Alternate gene names: 158336727

Gene position: 3650602-3651459 (Clockwise)

Preceding gene: 158336726

Following gene: 158336732

Centisome position: 56.13

GC content: 50.0

Gene sequence:

>858_bases
ATGCGGGCTAGAATTCGCGACACTGAACTTTACTTTGATGTGGAAGGTTCTGAACTTGCGATCGCAACCTCCCACATCCA
GCAAAAACCCGTATTCTTTGTCATCCATGGTGGGCCAGGAGTCGATCATACGACCTGCCGCCCCGTCCTATCGCCGCTCA
GTGAAATCGCTCAACTCGTCTATTTTGACCATCGGGGGCATGGTCGCTCGGCACGGGGTAATCCGGAGACCTATACTCTG
GACAATAATGTTGAAGATCTGGAGGCACTGCGCCAACATTTAGGGCTAGAACGGATTGGATTGCTTGGGTTTTCCTATGG
TGGGATGGTAGCCCTCGCCTATGCGAGCCGCTATCCTCGACATGTGTCTCAGTTGATTCCTGTTGTCACCGCTGCTGATT
CTCGTTTTCTAGCCTTAGCCCAGGCAAAGCTAGCTAAAGATGGAACCCCTGAGCAGCAAGCGATTGCCCAACTGCTATGG
GATGGCAAGTTTGAATCTGAGCAGCAACTCCAGGACTATTTTCAACTGTTAGGTCCGCTCTATTCTCTGACGTTCGATCT
CGATAAGTCGATGGAGGCTTGGCGTCGAGTGATTTTTAATCCTGAAGCGATCAATCAAGCTTTTGGAGGCTTTTTGAGAA
CCTATGATATTCGAGCTGACCTGCCTCAAATCTGCGCGCCAACCCTAGTGATCGGCGCTGAGCAAGATTGGATTTGCCCA
CCCCAATTTTCGGAAGAGATTGCTCAAGCTATTCCGAAGGCCAAGTTAGGCATTATCCCTAATTCTGGCCATTCGGTTCG
GGCAGATGCACCTGAAAAATTGCTCGAACTCATATCAAATTTTGTGAAGGGGGTGTGA

Upstream 100 bases:

>100_bases
AAGAAGGGGCTCAATTGGAGCCCCTTCTCTTTAGGTTAATTGGCAGATTTTCGTTGAGAGATCTAAAGTCTGGTCGTCGA
AAAAGCATGAGGGAATCACC

Downstream 100 bases:

>100_bases
TGCCAATACGTTCAACACAAGACTTCGAATCATACTGCAGATTCTAGCGGTACTGCTTGTCGGAGATTGCAGGTTCTTTG
ATTCCAAAAATAAGCACCCA

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP; Tricorn protease-interacting factor F1 [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRARIRDTELYFDVEGSELAIATSHIQQKPVFFVIHGGPGVDHTTCRPVLSPLSEIAQLVYFDHRGHGRSARGNPETYTL
DNNVEDLEALRQHLGLERIGLLGFSYGGMVALAYASRYPRHVSQLIPVVTAADSRFLALAQAKLAKDGTPEQQAIAQLLW
DGKFESEQQLQDYFQLLGPLYSLTFDLDKSMEAWRRVIFNPEAINQAFGGFLRTYDIRADLPQICAPTLVIGAEQDWICP
PQFSEEIAQAIPKAKLGIIPNSGHSVRADAPEKLLELISNFVKGV

Sequences:

>Translated_285_residues
MRARIRDTELYFDVEGSELAIATSHIQQKPVFFVIHGGPGVDHTTCRPVLSPLSEIAQLVYFDHRGHGRSARGNPETYTL
DNNVEDLEALRQHLGLERIGLLGFSYGGMVALAYASRYPRHVSQLIPVVTAADSRFLALAQAKLAKDGTPEQQAIAQLLW
DGKFESEQQLQDYFQLLGPLYSLTFDLDKSMEAWRRVIFNPEAINQAFGGFLRTYDIRADLPQICAPTLVIGAEQDWICP
PQFSEEIAQAIPKAKLGIIPNSGHSVRADAPEKLLELISNFVKGV
>Mature_285_residues
MRARIRDTELYFDVEGSELAIATSHIQQKPVFFVIHGGPGVDHTTCRPVLSPLSEIAQLVYFDHRGHGRSARGNPETYTL
DNNVEDLEALRQHLGLERIGLLGFSYGGMVALAYASRYPRHVSQLIPVVTAADSRFLALAQAKLAKDGTPEQQAIAQLLW
DGKFESEQQLQDYFQLLGPLYSLTFDLDKSMEAWRRVIFNPEAINQAFGGFLRTYDIRADLPQICAPTLVIGAEQDWICP
PQFSEEIAQAIPKAKLGIIPNSGHSVRADAPEKLLELISNFVKGV

Specific function: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome) yi

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 31687; Mature: 31687

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARIRDTELYFDVEGSELAIATSHIQQKPVFFVIHGGPGVDHTTCRPVLSPLSEIAQLV
CCCCEECCEEEEEECCCEEEEEHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
YFDHRGHGRSARGNPETYTLDNNVEDLEALRQHLGLERIGLLGFSYGGMVALAYASRYPR
HHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCHH
HVSQLIPVVTAADSRFLALAQAKLAKDGTPEQQAIAQLLWDGKFESEQQLQDYFQLLGPL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YSLTFDLDKSMEAWRRVIFNPEAINQAFGGFLRTYDIRADLPQICAPTLVIGAEQDWICP
HHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCHHHHCCEEEEECCCCCCCC
PQFSEEIAQAIPKAKLGIIPNSGHSVRADAPEKLLELISNFVKGV
CHHHHHHHHHCCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRARIRDTELYFDVEGSELAIATSHIQQKPVFFVIHGGPGVDHTTCRPVLSPLSEIAQLV
CCCCEECCEEEEEECCCEEEEEHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
YFDHRGHGRSARGNPETYTLDNNVEDLEALRQHLGLERIGLLGFSYGGMVALAYASRYPR
HHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCHH
HVSQLIPVVTAADSRFLALAQAKLAKDGTPEQQAIAQLLWDGKFESEQQLQDYFQLLGPL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YSLTFDLDKSMEAWRRVIFNPEAINQAFGGFLRTYDIRADLPQICAPTLVIGAEQDWICP
HHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCHHHHCCEEEEECCCCCCCC
PQFSEEIAQAIPKAKLGIIPNSGHSVRADAPEKLLELISNFVKGV
CHHHHHHHHHCCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946961; 11029001; 12374735 [H]