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The map label for this gene is hisD [H]

Identifier: 158336721

GI number: 158336721

Start: 3638422

End: 3639717

Strand: Reverse

Name: hisD [H]

Synonym: AM1_3589

Alternate gene names: 158336721

Gene position: 3639717-3638422 (Counterclockwise)

Preceding gene: 158336728

Following gene: 158336717

Centisome position: 55.96

GC content: 51.23

Gene sequence:

>1296_bases
ATGCTCCGAACCATTACCCAGCAAACGGAGGCAATTGCAGAACTGAGACGGATTTGCGATCGCACTCAGGATGACTCTCT
TCTTCACAAAGAATCGACCGTTCGAGAAATCCTAGCATCGGTCCAACGCCAAGGTGACTTAGCCCTGCTTCAATATACCG
CTGAGTTCGACCATCTCACTTTAAGCCTAGACCAGCTCAAAGTGAGCGGTGCCGAACTAGATGCGGCATATCAGCAGATT
CCTCAAGAGCGATTGGACGCTATTCGGTCTTATTCCCAGCAGATTAAAGCCTTTCACCTCAAGCAACGCCGTCAAAGTCA
GGTTCACTTTGGTGATCACCAAGTCGTGGTGGGTCAACGCTACACCCCCGTGGATCGGGTAGGTCTTTATATCCGAGGGA
CTCAAAACATTTCTCCTAGTCAAATCCTTTTAAATGCGATTCCTGCCGTTGTCGCTGGTGTCCCCAACATTGTGATGTTG
ACGCCACCCAGTCCGGAACAACAGATGCATCCTGCCGTACTAGTCGCAGCCCAGGAAGCTGGCATCGAAGCGATTTACCG
GGTGGGAGGTGCCCAAGGCATTGCAGCTTTGGCCTATGGGACGGCCACGATTCCTGCGGTAGATGTTATTGCCGGTAGTG
GAAATATCTACGTCACCCTGGCGAAGAAATTAGTGTATGGCTCTGTAGGCCTCGATGCTCTAACCGGACCTTCAGAACTG
GTTATTCTGGCAGATCATACCGCCAATCCTTCGTATATTGCTGCGGACCTACTAGCACACGCTGAATCCGACCCCCTTGC
AGCAGCTATTTTAATCACCTCAGATACAACCCTGGCAACCAAGGTCGTCTTGGAAGTGAATCAGACCTTATCCGGCTATG
GGATATTGACGGAAAAAGCGATCGCCCACTATGGCTTAGTCATTACTGTAGACGATATACAAAACGCGACGTCCCTCGTC
AATGGGATGGCCCCCGCTCAGGTTTCCCTTGCCCTTCATGATCCTTGGCGTTTAGTGGAGCATATTCGCCATGCTGGCTC
CATTCTCATGGGGTCTCACACGCCTCCCTCAGCAGGTCAGTTGCTGGTAGGTGCCAATCCCAATCTACCGACTGCAGGAA
CAGCACGTTATAGCTCTGGCCCTGGAGTCGAGACCTTTATGAAGCAAACTCATTTAATCCAATATTCGGCCAACGCTTTA
TCCCACTCGGCTCAACACTTAGATACCCTCGTCCAGCTAGAGGAGGAAACCGCACAATCACTCTCCCTGCGCATTCGATC
CAAACAGTCTGAGTAA

Upstream 100 bases:

>100_bases
GCATGAGTAGCCCCTTGTTCCCCGCCGCCTCTATAAATGCGTTACATTTGCAGAGAATGGCATCCTTTCCCTGGCGGTTG
CAGATAGGCATTTCAGAGTC

Downstream 100 bases:

>100_bases
GAGAACCGGGTCTACATTGTCTCCATGAATAAGGGTTATTCTGTCGGGGGGGATGGAGGATCTGCCGACCACACCCCTCC
CTTAAACCGGATCTTGGCTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLRTITQQTEAIAELRRICDRTQDDSLLHKESTVREILASVQRQGDLALLQYTAEFDHLTLSLDQLKVSGAELDAAYQQI
PQERLDAIRSYSQQIKAFHLKQRRQSQVHFGDHQVVVGQRYTPVDRVGLYIRGTQNISPSQILLNAIPAVVAGVPNIVML
TPPSPEQQMHPAVLVAAQEAGIEAIYRVGGAQGIAALAYGTATIPAVDVIAGSGNIYVTLAKKLVYGSVGLDALTGPSEL
VILADHTANPSYIAADLLAHAESDPLAAAILITSDTTLATKVVLEVNQTLSGYGILTEKAIAHYGLVITVDDIQNATSLV
NGMAPAQVSLALHDPWRLVEHIRHAGSILMGSHTPPSAGQLLVGANPNLPTAGTARYSSGPGVETFMKQTHLIQYSANAL
SHSAQHLDTLVQLEEETAQSLSLRIRSKQSE

Sequences:

>Translated_431_residues
MLRTITQQTEAIAELRRICDRTQDDSLLHKESTVREILASVQRQGDLALLQYTAEFDHLTLSLDQLKVSGAELDAAYQQI
PQERLDAIRSYSQQIKAFHLKQRRQSQVHFGDHQVVVGQRYTPVDRVGLYIRGTQNISPSQILLNAIPAVVAGVPNIVML
TPPSPEQQMHPAVLVAAQEAGIEAIYRVGGAQGIAALAYGTATIPAVDVIAGSGNIYVTLAKKLVYGSVGLDALTGPSEL
VILADHTANPSYIAADLLAHAESDPLAAAILITSDTTLATKVVLEVNQTLSGYGILTEKAIAHYGLVITVDDIQNATSLV
NGMAPAQVSLALHDPWRLVEHIRHAGSILMGSHTPPSAGQLLVGANPNLPTAGTARYSSGPGVETFMKQTHLIQYSANAL
SHSAQHLDTLVQLEEETAQSLSLRIRSKQSE
>Mature_431_residues
MLRTITQQTEAIAELRRICDRTQDDSLLHKESTVREILASVQRQGDLALLQYTAEFDHLTLSLDQLKVSGAELDAAYQQI
PQERLDAIRSYSQQIKAFHLKQRRQSQVHFGDHQVVVGQRYTPVDRVGLYIRGTQNISPSQILLNAIPAVVAGVPNIVML
TPPSPEQQMHPAVLVAAQEAGIEAIYRVGGAQGIAALAYGTATIPAVDVIAGSGNIYVTLAKKLVYGSVGLDALTGPSEL
VILADHTANPSYIAADLLAHAESDPLAAAILITSDTTLATKVVLEVNQTLSGYGILTEKAIAHYGLVITVDDIQNATSLV
NGMAPAQVSLALHDPWRLVEHIRHAGSILMGSHTPPSAGQLLVGANPNLPTAGTARYSSGPGVETFMKQTHLIQYSANAL
SHSAQHLDTLVQLEEETAQSLSLRIRSKQSE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=34.25, Blast_Score=197, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6319819, Length=386, Percent_Identity=32.9015544041451, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46272; Mature: 46272

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTITQQTEAIAELRRICDRTQDDSLLHKESTVREILASVQRQGDLALLQYTAEFDHLT
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
LSLDQLKVSGAELDAAYQQIPQERLDAIRSYSQQIKAFHLKQRRQSQVHFGDHQVVVGQR
EEHHHHEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
YTPVDRVGLYIRGTQNISPSQILLNAIPAVVAGVPNIVMLTPPSPEQQMHPAVLVAAQEA
CCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCEEEEEEHHH
GIEAIYRVGGAQGIAALAYGTATIPAVDVIAGSGNIYVTLAKKLVYGSVGLDALTGPSEL
CHHHHHHHCCCCCHHHEEECCCCCCEEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCCE
VILADHTANPSYIAADLLAHAESDPLAAAILITSDTTLATKVVLEVNQTLSGYGILTEKA
EEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHEEEECCCCCCCCCCHHHHH
IAHYGLVITVDDIQNATSLVNGMAPAQVSLALHDPWRLVEHIRHAGSILMGSHTPPSAGQ
HHHCCEEEEECCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCE
LLVGANPNLPTAGTARYSSGPGVETFMKQTHLIQYSANALSHSAQHLDTLVQLEEETAQS
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LSLRIRSKQSE
HHEEEECCCCC
>Mature Secondary Structure
MLRTITQQTEAIAELRRICDRTQDDSLLHKESTVREILASVQRQGDLALLQYTAEFDHLT
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEE
LSLDQLKVSGAELDAAYQQIPQERLDAIRSYSQQIKAFHLKQRRQSQVHFGDHQVVVGQR
EEHHHHEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
YTPVDRVGLYIRGTQNISPSQILLNAIPAVVAGVPNIVMLTPPSPEQQMHPAVLVAAQEA
CCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCEEEEEEHHH
GIEAIYRVGGAQGIAALAYGTATIPAVDVIAGSGNIYVTLAKKLVYGSVGLDALTGPSEL
CHHHHHHHCCCCCHHHEEECCCCCCEEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCCE
VILADHTANPSYIAADLLAHAESDPLAAAILITSDTTLATKVVLEVNQTLSGYGILTEKA
EEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHEEEECCCCCCCCCCHHHHH
IAHYGLVITVDDIQNATSLVNGMAPAQVSLALHDPWRLVEHIRHAGSILMGSHTPPSAGQ
HHHCCEEEEECCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCE
LLVGANPNLPTAGTARYSSGPGVETFMKQTHLIQYSANALSHSAQHLDTLVQLEEETAQS
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LSLRIRSKQSE
HHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA