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The map label for this gene is phoR [H]

Identifier: 158336599

GI number: 158336599

Start: 3499256

End: 3500449

Strand: Reverse

Name: phoR [H]

Synonym: AM1_3465

Alternate gene names: 158336599

Gene position: 3500449-3499256 (Counterclockwise)

Preceding gene: 158336600

Following gene: 158336596

Centisome position: 53.82

GC content: 49.5

Gene sequence:

>1194_bases
ATGGTTTTGGCGGGGATTATGGTTGTGTTTGCGATCGCAATCCGTACCACCTTCGCCTATACCCTGCACCATCAGGTCAG
CCAACGATTGCAAAATTTAGTGAAAGCGGGAAGTCTTGAACTCGAAATTGAAGACGGTCGCCTTGAACTCGATCAAGAAG
ATCTAGTGCGTGACCTTCAATCTCTGCAATGGTACGACCCTACAGGTCAGTTGGTAGGAACCCAAGGCCAGCCCGCCTCC
AATCTGCCTTTAGACCCCCAACAACTTGTTCGACTTCAGACTCACGCCAACCTCAAATCCATGACGGTGCCAGTTCAAGA
CCTCAATACTGGGCAGTTGATTGGCTTTGTCCGCGCCAATGAATCGTTAGAGGCCGTCAACCAAACCCTTCAACAGCTCG
ATTGGGGCTTAGGCGGTGGCGCTATTCTAGCGATTGTTCTCAGTGGAATAGGAGGAACCTGGTTAACCGCCCGAGCCATG
CATCCCATTGAGCAGAGCATGCGCCAACTCCAGCAATTTACAGCCGATGCCTCCCATGAACTGCGCAGTCCTCTCACGGC
GATTAAAACCAATGCAACCGTGGCCCAAAAATATCCCGAAGGGATGCGACAGACCGATGCTGAGAAATTTCAAGCCATCC
TCAGTGCAGTAAATCAGATGACTGCACTCACAGAATCCTTACTGCAATTGGCCCGACTTGACCAGTCTTCAGAACAGCAT
CAAGATCCCATTAATCTTTTGCACACCTTAGAGGAACTGAGTCAGCATTACCAACGCCAAGCTCAATCTAAAGGCATTAC
CCTGACCACTCAATTGGCAGAACCCACTTGGGTCTTAGGCCATGAAGATCAGCTTCGACAAGTGTTGGTCAACCTGCTGG
AGAATGCCTTGCGATATACCCCAACTGGAGGAGCAGTACAAGTAAGCAGTACCAGAGTCGGATCATCCATCCTGATTCAA
GTTCAAGATACGGGCATGGGAATAAAAGCGGAGCACCGGGAGAAAATCTTTGACCGATTTTGGCAAGCGGACACGTCCCG
GTCGTATCAGACAGAAGGATGTGGTCTAGGGCTAGCCATTGCTCGTCGTATTGTTCAACTTCATAAAGGGAACATTGCTG
TGGAAAGTGAATGGACACAAGGAAGTTGTTTTTCTATAAAACTCCCTCTGTATGACTCTTCTCCTGAGCGATGA

Upstream 100 bases:

>100_bases
ACGCTTTATGGTGTGGGCTATCGTCTGAATCCGCTTCTTCATTCCTAGAGGTTATGCATTGTTTCGGAAAGTTCGATTGC
AGCTCTTAGGATCCTATCTG

Downstream 100 bases:

>100_bases
TGCACTTCAAGCAGCATTGGGTCGCTAAACTTCACTGGCTTGGCGCACTATGCCTTGATCAAAGCAGTTACCATCAACGC
CAATACCTTGAATACTCAGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MVLAGIMVVFAIAIRTTFAYTLHHQVSQRLQNLVKAGSLELEIEDGRLELDQEDLVRDLQSLQWYDPTGQLVGTQGQPAS
NLPLDPQQLVRLQTHANLKSMTVPVQDLNTGQLIGFVRANESLEAVNQTLQQLDWGLGGGAILAIVLSGIGGTWLTARAM
HPIEQSMRQLQQFTADASHELRSPLTAIKTNATVAQKYPEGMRQTDAEKFQAILSAVNQMTALTESLLQLARLDQSSEQH
QDPINLLHTLEELSQHYQRQAQSKGITLTTQLAEPTWVLGHEDQLRQVLVNLLENALRYTPTGGAVQVSSTRVGSSILIQ
VQDTGMGIKAEHREKIFDRFWQADTSRSYQTEGCGLGLAIARRIVQLHKGNIAVESEWTQGSCFSIKLPLYDSSPER

Sequences:

>Translated_397_residues
MVLAGIMVVFAIAIRTTFAYTLHHQVSQRLQNLVKAGSLELEIEDGRLELDQEDLVRDLQSLQWYDPTGQLVGTQGQPAS
NLPLDPQQLVRLQTHANLKSMTVPVQDLNTGQLIGFVRANESLEAVNQTLQQLDWGLGGGAILAIVLSGIGGTWLTARAM
HPIEQSMRQLQQFTADASHELRSPLTAIKTNATVAQKYPEGMRQTDAEKFQAILSAVNQMTALTESLLQLARLDQSSEQH
QDPINLLHTLEELSQHYQRQAQSKGITLTTQLAEPTWVLGHEDQLRQVLVNLLENALRYTPTGGAVQVSSTRVGSSILIQ
VQDTGMGIKAEHREKIFDRFWQADTSRSYQTEGCGLGLAIARRIVQLHKGNIAVESEWTQGSCFSIKLPLYDSSPER
>Mature_397_residues
MVLAGIMVVFAIAIRTTFAYTLHHQVSQRLQNLVKAGSLELEIEDGRLELDQEDLVRDLQSLQWYDPTGQLVGTQGQPAS
NLPLDPQQLVRLQTHANLKSMTVPVQDLNTGQLIGFVRANESLEAVNQTLQQLDWGLGGGAILAIVLSGIGGTWLTARAM
HPIEQSMRQLQQFTADASHELRSPLTAIKTNATVAQKYPEGMRQTDAEKFQAILSAVNQMTALTESLLQLARLDQSSEQH
QDPINLLHTLEELSQHYQRQAQSKGITLTTQLAEPTWVLGHEDQLRQVLVNLLENALRYTPTGGAVQVSSTRVGSSILIQ
VQDTGMGIKAEHREKIFDRFWQADTSRSYQTEGCGLGLAIARRIVQLHKGNIAVESEWTQGSCFSIKLPLYDSSPER

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=31.8777292576419, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=32.4561403508772, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=32.9113924050633, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=30.0429184549356, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=30.5439330543933, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=33.4745762711864, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=28.9473684210526, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081816, Length=223, Percent_Identity=30.9417040358744, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=29.5652173913043, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=235, Percent_Identity=28.5106382978723, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=28.1632653061224, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=29.6803652968037, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789403, Length=229, Percent_Identity=33.1877729257642, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=30.7339449541284, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=210, Percent_Identity=30.4761904761905, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43988; Mature: 43988

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLAGIMVVFAIAIRTTFAYTLHHQVSQRLQNLVKAGSLELEIEDGRLELDQEDLVRDLQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCHHHHHHHHH
SLQWYDPTGQLVGTQGQPASNLPLDPQQLVRLQTHANLKSMTVPVQDLNTGQLIGFVRAN
HCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEHHCCCCCCEEEEEECC
ESLEAVNQTLQQLDWGLGGGAILAIVLSGIGGTWLTARAMHPIEQSMRQLQQFTADASHE
CHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSPLTAIKTNATVAQKYPEGMRQTDAEKFQAILSAVNQMTALTESLLQLARLDQSSEQH
HHCCHHHHHCCCHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
QDPINLLHTLEELSQHYQRQAQSKGITLTTQLAEPTWVLGHEDQLRQVLVNLLENALRYT
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCC
PTGGAVQVSSTRVGSSILIQVQDTGMGIKAEHREKIFDRFWQADTSRSYQTEGCGLGLAI
CCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
ARRIVQLHKGNIAVESEWTQGSCFSIKLPLYDSSPER
HHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MVLAGIMVVFAIAIRTTFAYTLHHQVSQRLQNLVKAGSLELEIEDGRLELDQEDLVRDLQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCHHHHHHHHH
SLQWYDPTGQLVGTQGQPASNLPLDPQQLVRLQTHANLKSMTVPVQDLNTGQLIGFVRAN
HCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEHHCCCCCCEEEEEECC
ESLEAVNQTLQQLDWGLGGGAILAIVLSGIGGTWLTARAMHPIEQSMRQLQQFTADASHE
CHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSPLTAIKTNATVAQKYPEGMRQTDAEKFQAILSAVNQMTALTESLLQLARLDQSSEQH
HHCCHHHHHCCCHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
QDPINLLHTLEELSQHYQRQAQSKGITLTTQLAEPTWVLGHEDQLRQVLVNLLENALRYT
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCC
PTGGAVQVSSTRVGSSILIQVQDTGMGIKAEHREKIFDRFWQADTSRSYQTEGCGLGLAI
CCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
ARRIVQLHKGNIAVESEWTQGSCFSIKLPLYDSSPER
HHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]