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The map label for this gene is hmrR [H]

Identifier: 158336596

GI number: 158336596

Start: 3496730

End: 3497146

Strand: Reverse

Name: hmrR [H]

Synonym: AM1_3462

Alternate gene names: 158336596

Gene position: 3497146-3496730 (Counterclockwise)

Preceding gene: 158336599

Following gene: 158336595

Centisome position: 53.77

GC content: 47.72

Gene sequence:

>417_bases
ATGACAAGAGCCACACGCCTGAAAATTGGTGAGGTTCGACAGCAAACTGGGGTTGCTGTTGGGGCGTTACGATACTACGA
AAGCTTAGAGTTAATTCACTCGGATCGAGGAGACAATGGCTACCGCTATTATCCCCAAGAGACCGTGCAGCAGGTGCAGT
TTATCAAGAAGGCACAAACCTTGGGGTTCTCCTTAGAGGAAATTCGAGAAATCCTCAATATTCACCAACAAGGGGACATC
CCTTGTGAACGGGTGCAGTCGATGCTGCAAGGCAAGATTGAACAGCTTGACCATCAAATCCAGCAGATAATGTCTTTTAA
ATCTGAATTGGAACACTATCGAGATCGCTGGGCCACCAACCAGCCCCGACCTCAACCCGGTGATATCTGTCCTTTGATTT
CAACCGTTTCCTTGTAA

Upstream 100 bases:

>100_bases
AGAGAGTCAAGGGGCAAATATCGCGCACCTGGGTGATGGGCTTGACCCTACAGTTGACTGTAGGGTTTAAAGTAAAGGTA
GTTTTCTACTCAACGAAAAG

Downstream 100 bases:

>100_bases
CGCTTATGCGAGTATTACTGGTCGAAGATGAACCGGATCTGGGCGCTGCCATTCAGCGCACTCTCACCCAGGAAGCTTAT
ATTGTGGATTGGGCGAAAGA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 138; Mature: 137

Protein sequence:

>138_residues
MTRATRLKIGEVRQQTGVAVGALRYYESLELIHSDRGDNGYRYYPQETVQQVQFIKKAQTLGFSLEEIREILNIHQQGDI
PCERVQSMLQGKIEQLDHQIQQIMSFKSELEHYRDRWATNQPRPQPGDICPLISTVSL

Sequences:

>Translated_138_residues
MTRATRLKIGEVRQQTGVAVGALRYYESLELIHSDRGDNGYRYYPQETVQQVQFIKKAQTLGFSLEEIREILNIHQQGDI
PCERVQSMLQGKIEQLDHQIQQIMSFKSELEHYRDRWATNQPRPQPGDICPLISTVSL
>Mature_137_residues
TRATRLKIGEVRQQTGVAVGALRYYESLELIHSDRGDNGYRYYPQETVQQVQFIKKAQTLGFSLEEIREILNIHQQGDIP
CERVQSMLQGKIEQLDHQIQQIMSFKSELEHYRDRWATNQPRPQPGDICPLISTVSL

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=110, Percent_Identity=30.9090909090909, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16029; Mature: 15898

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRATRLKIGEVRQQTGVAVGALRYYESLELIHSDRGDNGYRYYPQETVQQVQFIKKAQT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHH
LGFSLEEIREILNIHQQGDIPCERVQSMLQGKIEQLDHQIQQIMSFKSELEHYRDRWATN
HCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QPRPQPGDICPLISTVSL
CCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TRATRLKIGEVRQQTGVAVGALRYYESLELIHSDRGDNGYRYYPQETVQQVQFIKKAQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHH
LGFSLEEIREILNIHQQGDIPCERVQSMLQGKIEQLDHQIQQIMSFKSELEHYRDRWATN
HCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QPRPQPGDICPLISTVSL
CCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]