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The map label for this gene is hemB [H]

Identifier: 158336209

GI number: 158336209

Start: 3095127

End: 3096161

Strand: Direct

Name: hemB [H]

Synonym: AM1_3071

Alternate gene names: 158336209

Gene position: 3095127-3096161 (Clockwise)

Preceding gene: 158336208

Following gene: 158336210

Centisome position: 47.59

GC content: 52.75

Gene sequence:

>1035_bases
ATGGTCATTTCCCAACCTAAGCCCCAAGAATCTGAGGTCAATCCGTCCGTTAGCACCCCTGCTATCCGCCATCGACCTCG
GCGGTTACGACGCACTGACGCCTTGCGGCGATTGGTGCGGGAAACTCAGTTAACCCTCGATGATCTGATCTATCCCGTGT
TTGTGCGAGAGGGGACGGAGATTGAGGAGGCCATTCCATCCATGCCCGGGATTTATCGCTACTCCCTGGATGTATTGCTC
AAGGAATTGGCAGTCGTGTTACGACTAGGGATTAAAGCCATTGCCCTGTTTCCCCTTATCCCGGCTGAACAAAAAGATAA
TGCGGGCACCGAAAGTTATAACCCCGAGGGTTTAGTGCCTCGCACCGTTAAAGCGATCAAGGCGGAATTTCCTGAGCTTC
TGGTGATGACTGATGTGGCCCTAGACCCCTACAGCAGTGCAGGCCATGACGGGATTGTGGAAGACGGCGTCATTCTCAAT
GATGAAACCGTAGACGTGTTAGTGAAACAAGCCCTATGTCAGGCCGAAGCAGGCGCTGACTTTGTCTGTCCTTCAGACAT
GATGGATGGTCGAGTGGGCGCCATGCGCCAAGCCCTGGATGCTGACGGGTGGACCCAGGTGGGAATTTTAGCCTATTCCG
CCAAATATGCTTCAGCCTACTATGGTCCCTTTCGCGATGCCCTAGACTCTGCTCCCCAGTTTGGGGATAAGAAAACCTAT
CAAATGGACCCTGCCAACGCCCGCGAAGCCTTGAAGGAAGTGGCTTTAGATGTGAGTGAAGGTGCAGATCTAGTGATGGT
CAAACCGGCCCTCGCTTACCTGGATATTATTAGCCAGATTAAGCAAGCCACCACCCTACCTGTGGTCGCCTACAACGTCA
GCGGTGAGTACGCCATGATTAAAGCCGCCGCTGAACGAGGATGGATTGATGAACCGTCCGTAGTGCTGGAAACCTTAACC
AGTATGAAACGAGCGGGAGCCGATTTAATTTTGACCTACTTTGCCAAGCAGGTTGCACTGACCTGGCTTCCATAA

Upstream 100 bases:

>100_bases
CAGTACCGAGATATTCCCACGAAAGAAAAAGATTTTCTGAAGCCTCTGCTTAGTCCAATTTCCTAGGATATGATAACGAT
TATCATTCTTCTCAATCCTT

Downstream 100 bases:

>100_bases
AATTGCCCTGCGTTTGCCCTTGTCTCAACTATTAGGAATGTTGCCATGACCCCTAACTCTTCTCGTCCCTCTCGGCTGCA
AAAATACCAACTCTCCATCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVISQPKPQESEVNPSVSTPAIRHRPRRLRRTDALRRLVRETQLTLDDLIYPVFVREGTEIEEAIPSMPGIYRYSLDVLL
KELAVVLRLGIKAIALFPLIPAEQKDNAGTESYNPEGLVPRTVKAIKAEFPELLVMTDVALDPYSSAGHDGIVEDGVILN
DETVDVLVKQALCQAEAGADFVCPSDMMDGRVGAMRQALDADGWTQVGILAYSAKYASAYYGPFRDALDSAPQFGDKKTY
QMDPANAREALKEVALDVSEGADLVMVKPALAYLDIISQIKQATTLPVVAYNVSGEYAMIKAAAERGWIDEPSVVLETLT
SMKRAGADLILTYFAKQVALTWLP

Sequences:

>Translated_344_residues
MVISQPKPQESEVNPSVSTPAIRHRPRRLRRTDALRRLVRETQLTLDDLIYPVFVREGTEIEEAIPSMPGIYRYSLDVLL
KELAVVLRLGIKAIALFPLIPAEQKDNAGTESYNPEGLVPRTVKAIKAEFPELLVMTDVALDPYSSAGHDGIVEDGVILN
DETVDVLVKQALCQAEAGADFVCPSDMMDGRVGAMRQALDADGWTQVGILAYSAKYASAYYGPFRDALDSAPQFGDKKTY
QMDPANAREALKEVALDVSEGADLVMVKPALAYLDIISQIKQATTLPVVAYNVSGEYAMIKAAAERGWIDEPSVVLETLT
SMKRAGADLILTYFAKQVALTWLP
>Mature_344_residues
MVISQPKPQESEVNPSVSTPAIRHRPRRLRRTDALRRLVRETQLTLDDLIYPVFVREGTEIEEAIPSMPGIYRYSLDVLL
KELAVVLRLGIKAIALFPLIPAEQKDNAGTESYNPEGLVPRTVKAIKAEFPELLVMTDVALDPYSSAGHDGIVEDGVILN
DETVDVLVKQALCQAEAGADFVCPSDMMDGRVGAMRQALDADGWTQVGILAYSAKYASAYYGPFRDALDSAPQFGDKKTY
QMDPANAREALKEVALDVSEGADLVMVKPALAYLDIISQIKQATTLPVVAYNVSGEYAMIKAAAERGWIDEPSVVLETLT
SMKRAGADLILTYFAKQVALTWLP

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:
GO:0003824: Delta-aminolevulinic acid dehydratase
GO:0004655: Delta-aminolevulinic acid dehydratase
GO:0006779: Delta-aminolevulinic acid dehydratase
GO:0008152: Delta-aminolevulinic acid dehydratase
GO:0016829: Delta-aminolevulinic acid dehydratase
GO:0033014: Delta-aminolevulinic acid dehydratase
GO:0046872: Delta-aminolevulinic acid dehydratase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=41.9672131147541, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI87081728, Length=316, Percent_Identity=48.1012658227848, Blast_Score=291, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6321398, Length=314, Percent_Identity=41.4012738853503, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=38.4105960264901, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37689; Mature: 37689

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISQPKPQESEVNPSVSTPAIRHRPRRLRRTDALRRLVRETQLTLDDLIYPVFVREGTE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IEEAIPSMPGIYRYSLDVLLKELAVVLRLGIKAIALFPLIPAEQKDNAGTESYNPEGLVP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
RTVKAIKAEFPELLVMTDVALDPYSSAGHDGIVEDGVILNDETVDVLVKQALCQAEAGAD
HHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC
FVCPSDMMDGRVGAMRQALDADGWTQVGILAYSAKYASAYYGPFRDALDSAPQFGDKKTY
CCCCHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCE
QMDPANAREALKEVALDVSEGADLVMVKPALAYLDIISQIKQATTLPVVAYNVSGEYAMI
EECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEE
KAAAERGWIDEPSVVLETLTSMKRAGADLILTYFAKQVALTWLP
EHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVISQPKPQESEVNPSVSTPAIRHRPRRLRRTDALRRLVRETQLTLDDLIYPVFVREGTE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IEEAIPSMPGIYRYSLDVLLKELAVVLRLGIKAIALFPLIPAEQKDNAGTESYNPEGLVP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
RTVKAIKAEFPELLVMTDVALDPYSSAGHDGIVEDGVILNDETVDVLVKQALCQAEAGAD
HHHHHHHHHCCCEEEHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC
FVCPSDMMDGRVGAMRQALDADGWTQVGILAYSAKYASAYYGPFRDALDSAPQFGDKKTY
CCCCHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCE
QMDPANAREALKEVALDVSEGADLVMVKPALAYLDIISQIKQATTLPVVAYNVSGEYAMI
EECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEE
KAAAERGWIDEPSVVLETLTSMKRAGADLILTYFAKQVALTWLP
EHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]