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The map label for this gene is hisI [H]

Identifier: 158336191

GI number: 158336191

Start: 3075719

End: 3076204

Strand: Reverse

Name: hisI [H]

Synonym: AM1_3053

Alternate gene names: 158336191

Gene position: 3076204-3075719 (Counterclockwise)

Preceding gene: 158336192

Following gene: 158336190

Centisome position: 47.3

GC content: 50.41

Gene sequence:

>486_bases
ATGCCCCTCCCCTTTGCTCAGCGTACCTCTGTCGAAGAAGTTGAAGAAGGATCGCTGCTTTCCCCCAAATTTGATTCAGA
CGGTTTAATGCCTGTGGTGACGACTGATGCCCAGACAGGTGAACTATTGATGCATGCCTATATGAATCAAACTGCGCTGA
TGAAAACGATTGAAACGGGAGAGGCCCATTACTACAGCCGCAGTCGCCAGACCCTCTGGCATAAAGGGGCGACTAGTGGC
TTGGTTCAGTATGTCCAGCAGTTACTGATTGATGATGATCAAGACTGTCTGTGGATGCGGGTGACTGTTGCGGGCTCTGG
AGCCAGTTGCCATGTGGGTTATCGATCCTGTTTTTATCGTCAAATTCCCGTGGGGACAGAAGCCGTGGATAGTTCCTCTC
CCATTGCTTTGACTTTCACTGAAGCTGCTAAAACCTTTGACCCTCAACAGGTCTATGGGGATGCCCCTAATCCGACGCAG
CTTTGA

Upstream 100 bases:

>100_bases
TCGCTGGCTCATTGTGGATCACCACTCCTCCGGCATGCCGGAAAAAATGTCCTAAGAATAACTACTGTTTAACTGTTTTG
CCCAATCCCTGAGAACTACC

Downstream 100 bases:

>100_bases
AGGGTTCAGCCGACTTTAAACCAATGGAGTATTAAAGATGCCTCTACGTCAGCAACCTTCGCCTCCGACTCCTTGGGATC
GAGGGTTAGATCAGCCTCAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MPLPFAQRTSVEEVEEGSLLSPKFDSDGLMPVVTTDAQTGELLMHAYMNQTALMKTIETGEAHYYSRSRQTLWHKGATSG
LVQYVQQLLIDDDQDCLWMRVTVAGSGASCHVGYRSCFYRQIPVGTEAVDSSSPIALTFTEAAKTFDPQQVYGDAPNPTQ
L

Sequences:

>Translated_161_residues
MPLPFAQRTSVEEVEEGSLLSPKFDSDGLMPVVTTDAQTGELLMHAYMNQTALMKTIETGEAHYYSRSRQTLWHKGATSG
LVQYVQQLLIDDDQDCLWMRVTVAGSGASCHVGYRSCFYRQIPVGTEAVDSSSPIALTFTEAAKTFDPQQVYGDAPNPTQ
L
>Mature_160_residues
PLPFAQRTSVEEVEEGSLLSPKFDSDGLMPVVTTDAQTGELLMHAYMNQTALMKTIETGEAHYYSRSRQTLWHKGATSGL
VQYVQQLLIDDDQDCLWMRVTVAGSGASCHVGYRSCFYRQIPVGTEAVDSSSPIALTFTEAAKTFDPQQVYGDAPNPTQL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=93, Percent_Identity=46.2365591397849, Blast_Score=81, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 17743; Mature: 17612

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPFAQRTSVEEVEEGSLLSPKFDSDGLMPVVTTDAQTGELLMHAYMNQTALMKTIETG
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHCC
EAHYYSRSRQTLWHKGATSGLVQYVQQLLIDDDQDCLWMRVTVAGSGASCHVGYRSCFYR
CCHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECHHHHHHE
QIPVGTEAVDSSSPIALTFTEAAKTFDPQQVYGDAPNPTQL
ECCCCCCCCCCCCCEEEEEECHHHCCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
PLPFAQRTSVEEVEEGSLLSPKFDSDGLMPVVTTDAQTGELLMHAYMNQTALMKTIETG
CCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHCC
EAHYYSRSRQTLWHKGATSGLVQYVQQLLIDDDQDCLWMRVTVAGSGASCHVGYRSCFYR
CCHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECHHHHHHE
QIPVGTEAVDSSSPIALTFTEAAKTFDPQQVYGDAPNPTQL
ECCCCCCCCCCCCCEEEEEECHHHCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA