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The map label for this gene is sdhA [H]

Identifier: 158335926

GI number: 158335926

Start: 2815307

End: 2817034

Strand: Direct

Name: sdhA [H]

Synonym: AM1_2784

Alternate gene names: 158335926

Gene position: 2815307-2817034 (Clockwise)

Preceding gene: 158335924

Following gene: 158335929

Centisome position: 43.29

GC content: 52.08

Gene sequence:

>1728_bases
ATGTTAGAGCATGATGTTGTAATCGTTGGGGGTGGCTTGGCAGGGTGCCGTGCTGCCCTAGAAATTGCTCGAAAAGCCCC
CGAGCTCAATGTGGCAATGATTGCCAAAACCCATCCCATCCGATCCCACTCCGTTGCGGCCCAAGGGGGCATTGCCGCCA
CCCTCAAAAATGTGGATGATCAAGATAGCTGGGAAGCCCATGCCTTCGATACCATCAAAGGCTCCGATTACCTAGCCGAT
CAGGATGCCGTCGCTCTCCTCACCCAAGAAGCCCCAGATGTTGTGATTGACCTGGAACATCTAGGGGTTTTGTTTTCTCG
CCTGGAAGATGGCCGCATCGCCCAGCGTGCCTTTGGCGGTCACAGCCATAACCGCACCTGTTACGCCGCTGACAAAACGG
GTCATGCCATTCTTCACGAGCTGTACAACAATATTCGTCGCTATGGCATCACTATCTACGACGAATGGTACGTTATGCGG
CTGATCCTCGAAGACAACCGGGCCAAAGGCGTGGTGATGTATCACCTCCTGGACGGCGAGCTACAGGTTCTACGGGCCAA
GGCTGTCATGTTTGCCACGGGCGGTTACGGTCGAGTCTTTAACACCACTTCCAATGACTTTGCGTCCACGGGGGATGGGT
TATCGATGACCGCCCTGGCGGGGTTGCCCCTAGAGGATATGGAGTTTGTCCAGTTCCATCCCACCGGCTTATACCCTGCA
GGCGTGTTGATTTCCGAGGCCGTGCGAGGAGAAGGAGCTTATCTGATTAATAGTGAAGGGGATCGGTTTATGGCCACCTA
TGCCCCCAACAAAATGGAGCTGGCCCCCCGCGATATTACCTCTAGAGCCATTACCACAGAAATTCGCCAGGGGCGGGGTC
TCAATCTCGATGGCAGTGCCGGTGGACCCTTTGTCTACTTAGATTTGCGGCATATGGGACGGGAGAAAATCATGAGCCGC
GTTCCCTTTTGCTGGGAAGAATCTCACCGTCTAGCAGGGGTTGATGCGGTTACTGAGCCGATCCCCGTTCGGCCAACTGC
CCACTATTCCATGGGGGGGATTCCCGTGAATACGGATGGGCGGGTGCGCAATAGTGCCGATGGCTTGGTGGATAACTTTT
TTGCAGCCGGGGAATGTGCCTGTGTGTCGGTGCATGGCGCGAATCGGTTAGGCAGCAATTCTTTACTGGAATGCGTGGTA
TATGGTCGGCGTACTGGGAGTGCGATCGCAACCTATGTCCAAGATCAATCTCTCCCTAGGGTGAATGAAACCCAGTATCT
CCAAGAAGCTCAACAGCAGATTAAAGCGTTGCTGGCTCAATCTGGAGATATCCGCATTCACGATATTCGCCAGCAAGTCC
AAGATTGCTTAAGTCAACATTGTGGTGTTTTTCGGACCGCCGATATCATCCAAGAAGGCTTAGAACAGCTCCAAACCTAT
AAACAGCAGTATTCAAATATTCGCCTCGATGACAAAGACACCCTTTGGAATACTGAAATTATCGAGGCCCTGGAATTACG
CAACTTAATGGTCGTCGGAGAAGTGATTATGACTGGTGCCCTGCAACGCCAAGAAAGCCGGGGTGCCCATTCTCGTGAAG
ATTTCCCTACCCGCAACGATAATCAATTTTTGCAGCATACCCTAGCTTATTTTTCCACAGCCGGGATTGAGCTAAAATAC
ATGCCCGTTAATTTAAACCAATTTGAGCCTCAAGAGAGAAAATACTGA

Upstream 100 bases:

>100_bases
TGAGGTGAGTATATCACTATTACAAAACCCTGTAGCTAAGGATTCATAAAGAATATGTGCGATAGATTTGGAACGTATTC
GAAGCTGTAAAGAAACTGCC

Downstream 100 bases:

>100_bases
TTTATATCCGCAAAAGTATCTTTCTATTCGATTTAATATTACCCATCATCATTTTTACTTGCGAATAGTTCTTCTCAATA
GCTTTATCTTTAATCTCTTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MLEHDVVIVGGGLAGCRAALEIARKAPELNVAMIAKTHPIRSHSVAAQGGIAATLKNVDDQDSWEAHAFDTIKGSDYLAD
QDAVALLTQEAPDVVIDLEHLGVLFSRLEDGRIAQRAFGGHSHNRTCYAADKTGHAILHELYNNIRRYGITIYDEWYVMR
LILEDNRAKGVVMYHLLDGELQVLRAKAVMFATGGYGRVFNTTSNDFASTGDGLSMTALAGLPLEDMEFVQFHPTGLYPA
GVLISEAVRGEGAYLINSEGDRFMATYAPNKMELAPRDITSRAITTEIRQGRGLNLDGSAGGPFVYLDLRHMGREKIMSR
VPFCWEESHRLAGVDAVTEPIPVRPTAHYSMGGIPVNTDGRVRNSADGLVDNFFAAGECACVSVHGANRLGSNSLLECVV
YGRRTGSAIATYVQDQSLPRVNETQYLQEAQQQIKALLAQSGDIRIHDIRQQVQDCLSQHCGVFRTADIIQEGLEQLQTY
KQQYSNIRLDDKDTLWNTEIIEALELRNLMVVGEVIMTGALQRQESRGAHSREDFPTRNDNQFLQHTLAYFSTAGIELKY
MPVNLNQFEPQERKY

Sequences:

>Translated_575_residues
MLEHDVVIVGGGLAGCRAALEIARKAPELNVAMIAKTHPIRSHSVAAQGGIAATLKNVDDQDSWEAHAFDTIKGSDYLAD
QDAVALLTQEAPDVVIDLEHLGVLFSRLEDGRIAQRAFGGHSHNRTCYAADKTGHAILHELYNNIRRYGITIYDEWYVMR
LILEDNRAKGVVMYHLLDGELQVLRAKAVMFATGGYGRVFNTTSNDFASTGDGLSMTALAGLPLEDMEFVQFHPTGLYPA
GVLISEAVRGEGAYLINSEGDRFMATYAPNKMELAPRDITSRAITTEIRQGRGLNLDGSAGGPFVYLDLRHMGREKIMSR
VPFCWEESHRLAGVDAVTEPIPVRPTAHYSMGGIPVNTDGRVRNSADGLVDNFFAAGECACVSVHGANRLGSNSLLECVV
YGRRTGSAIATYVQDQSLPRVNETQYLQEAQQQIKALLAQSGDIRIHDIRQQVQDCLSQHCGVFRTADIIQEGLEQLQTY
KQQYSNIRLDDKDTLWNTEIIEALELRNLMVVGEVIMTGALQRQESRGAHSREDFPTRNDNQFLQHTLAYFSTAGIELKY
MPVNLNQFEPQERKY
>Mature_575_residues
MLEHDVVIVGGGLAGCRAALEIARKAPELNVAMIAKTHPIRSHSVAAQGGIAATLKNVDDQDSWEAHAFDTIKGSDYLAD
QDAVALLTQEAPDVVIDLEHLGVLFSRLEDGRIAQRAFGGHSHNRTCYAADKTGHAILHELYNNIRRYGITIYDEWYVMR
LILEDNRAKGVVMYHLLDGELQVLRAKAVMFATGGYGRVFNTTSNDFASTGDGLSMTALAGLPLEDMEFVQFHPTGLYPA
GVLISEAVRGEGAYLINSEGDRFMATYAPNKMELAPRDITSRAITTEIRQGRGLNLDGSAGGPFVYLDLRHMGREKIMSR
VPFCWEESHRLAGVDAVTEPIPVRPTAHYSMGGIPVNTDGRVRNSADGLVDNFFAAGECACVSVHGANRLGSNSLLECVV
YGRRTGSAIATYVQDQSLPRVNETQYLQEAQQQIKALLAQSGDIRIHDIRQQVQDCLSQHCGVFRTADIIQEGLEQLQTY
KQQYSNIRLDDKDTLWNTEIIEALELRNLMVVGEVIMTGALQRQESRGAHSREDFPTRNDNQFLQHTLAYFSTAGIELKY
MPVNLNQFEPQERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=566, Percent_Identity=42.5795053003534, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1786942, Length=589, Percent_Identity=43.2937181663837, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1790597, Length=566, Percent_Identity=39.3992932862191, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=33.273381294964, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17550100, Length=528, Percent_Identity=44.6969696969697, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17505833, Length=571, Percent_Identity=41.6812609457093, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71986328, Length=433, Percent_Identity=27.7136258660508, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322416, Length=585, Percent_Identity=42.0512820512821, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322701, Length=558, Percent_Identity=41.2186379928315, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320788, Length=481, Percent_Identity=29.1060291060291, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322511, Length=70, Percent_Identity=48.5714285714286, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137288, Length=527, Percent_Identity=44.022770398482, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24655642, Length=527, Percent_Identity=44.022770398482, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24655647, Length=527, Percent_Identity=44.022770398482, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24663005, Length=529, Percent_Identity=39.6975425330813, Blast_Score=404, Evalue=1e-112,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63719; Mature: 63719

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHDVVIVGGGLAGCRAALEIARKAPELNVAMIAKTHPIRSHSVAAQGGIAATLKNVDD
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCC
QDSWEAHAFDTIKGSDYLADQDAVALLTQEAPDVVIDLEHLGVLFSRLEDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCCCHHEEEECCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHNRTCYAADKTGHAILHELYNNIRRYGITIYDEWYVMRLILEDNRAKGVVMYHLLDGE
CCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECEEEEEEEEECCCCCCEEEEEEECCC
LQVLRAKAVMFATGGYGRVFNTTSNDFASTGDGLSMTALAGLPLEDMEFVQFHPTGLYPA
HHHEEEEEEEEEECCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINSEGDRFMATYAPNKMELAPRDITSRAITTEIRQGRGLNLDGSA
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCC
GGPFVYLDLRHMGREKIMSRVPFCWEESHRLAGVDAVTEPIPVRPTAHYSMGGIPVNTDG
CCCEEEEEHHHCCHHHHHHHCCCCCCCCCCEECCHHHCCCCCCCCCCCCCCCCEEECCCC
RVRNSADGLVDNFFAAGECACVSVHGANRLGSNSLLECVVYGRRTGSAIATYVQDQSLPR
CCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
VNETQYLQEAQQQIKALLAQSGDIRIHDIRQQVQDCLSQHCGVFRTADIIQEGLEQLQTY
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KQQYSNIRLDDKDTLWNTEIIEALELRNLMVVGEVIMTGALQRQESRGAHSREDFPTRND
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NQFLQHTLAYFSTAGIELKYMPVNLNQFEPQERKY
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHCCC
>Mature Secondary Structure
MLEHDVVIVGGGLAGCRAALEIARKAPELNVAMIAKTHPIRSHSVAAQGGIAATLKNVDD
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCC
QDSWEAHAFDTIKGSDYLADQDAVALLTQEAPDVVIDLEHLGVLFSRLEDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCCCHHEEEECCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHNRTCYAADKTGHAILHELYNNIRRYGITIYDEWYVMRLILEDNRAKGVVMYHLLDGE
CCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECEEEEEEEEECCCCCCEEEEEEECCC
LQVLRAKAVMFATGGYGRVFNTTSNDFASTGDGLSMTALAGLPLEDMEFVQFHPTGLYPA
HHHEEEEEEEEEECCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINSEGDRFMATYAPNKMELAPRDITSRAITTEIRQGRGLNLDGSA
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCC
GGPFVYLDLRHMGREKIMSRVPFCWEESHRLAGVDAVTEPIPVRPTAHYSMGGIPVNTDG
CCCEEEEEHHHCCHHHHHHHCCCCCCCCCCEECCHHHCCCCCCCCCCCCCCCCEEECCCC
RVRNSADGLVDNFFAAGECACVSVHGANRLGSNSLLECVVYGRRTGSAIATYVQDQSLPR
CCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
VNETQYLQEAQQQIKALLAQSGDIRIHDIRQQVQDCLSQHCGVFRTADIIQEGLEQLQTY
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KQQYSNIRLDDKDTLWNTEIIEALELRNLMVVGEVIMTGALQRQESRGAHSREDFPTRND
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NQFLQHTLAYFSTAGIELKYMPVNLNQFEPQERKY
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA