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The map label for this gene is umuD [H]

Identifier: 158335678

GI number: 158335678

Start: 2562980

End: 2563225

Strand: Direct

Name: umuD [H]

Synonym: AM1_2528

Alternate gene names: 158335678

Gene position: 2562980-2563225 (Clockwise)

Preceding gene: 158335677

Following gene: 158335679

Centisome position: 39.41

GC content: 50.0

Gene sequence:

>246_bases
ATGGAAGGCTGTGGAATCTTCTCGGGGGATTTATTGATTGTGGATCGCTCCCTAACCCCCGTCGATGGGGCCGTAGTGAT
TGCTGTCTTAAACGGCGAGTTTACGGTGAAACAGCTGCGATTATCGCAAAAAACAATTTTATTAGCTGCCGCCAATGCAG
ACTATACCCCCATCGTCGTCAAAGCCGGAATGGAATTTCAGGTGTGGGGTGTGGTCACCTATGTGGTGCATGGGTTGCAG
GTTTGA

Upstream 100 bases:

>100_bases
TTCCCCAGCCGATGACCATTTACAGAACAATTTGAATCTGCAAGAAGCGCTCATTCCTCGCCCTGCTGCGACGTTTTTGA
TGCGTGTCAAAGGAGATTCG

Downstream 100 bases:

>100_bases
AACAGCGTCTAATCGGGCTGTGTGACTGCAACTCGTTCTATGCCTCCTGTGAAATGGCGCTCAATCCCCACTTGCAACAT
AAGCCGGTTGTGATCGCTTC

Product: SOS mutagenesis protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 81; Mature: 81

Protein sequence:

>81_residues
MEGCGIFSGDLLIVDRSLTPVDGAVVIAVLNGEFTVKQLRLSQKTILLAAANADYTPIVVKAGMEFQVWGVVTYVVHGLQ
V

Sequences:

>Translated_81_residues
MEGCGIFSGDLLIVDRSLTPVDGAVVIAVLNGEFTVKQLRLSQKTILLAAANADYTPIVVKAGMEFQVWGVVTYVVHGLQ
V
>Mature_81_residues
MEGCGIFSGDLLIVDRSLTPVDGAVVIAVLNGEFTVKQLRLSQKTILLAAANADYTPIVVKAGMEFQVWGVVTYVVHGLQ
V

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:
GO:0003677: SOS mutagenesis protein UmuD, putative
GO:0006281: SOS mutagenesis protein UmuD, putative
GO:0006355: SOS mutagenesis protein UmuD, putative
GO:0006974: SOS mutagenesis protein UmuD, putative
GO:0009432: SOS mutagenesis protein UmuD, putative
GO:0016787: SOS mutagenesis protein UmuD, putative

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=76, Percent_Identity=44.7368421052632, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 8647; Mature: 8647

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGCGIFSGDLLIVDRSLTPVDGAVVIAVLNGEFTVKQLRLSQKTILLAAANADYTPIVV
CCCCCEEECCEEEEECCCCCCCCEEEEEEECCCEEEEEEECCCEEEEEEECCCCCCEEEE
KAGMEFQVWGVVTYVVHGLQV
ECCCEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MEGCGIFSGDLLIVDRSLTPVDGAVVIAVLNGEFTVKQLRLSQKTILLAAANADYTPIVV
CCCCCEEECCEEEEECCCCCCCCEEEEEEECCCEEEEEEECCCEEEEEEECCCCCCEEEE
KAGMEFQVWGVVTYVVHGLQV
ECCCEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]