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The map label for this gene is mpg [H]

Identifier: 158335677

GI number: 158335677

Start: 2561374

End: 2562504

Strand: Direct

Name: mpg [H]

Synonym: AM1_2527

Alternate gene names: 158335677

Gene position: 2561374-2562504 (Clockwise)

Preceding gene: 158335676

Following gene: 158335678

Centisome position: 39.38

GC content: 46.33

Gene sequence:

>1131_bases
ATGAAAGCAATGATTTTGGCGGCTGGTAAAGGCACCCGCGTTCGCCCAATAACGTTCACGATTCCCAAGCCCATGATTCC
GATCATGCAGAAACCTGTAATGGAGTTTCTAGTCGATCTACTTCGGCAACATGGTTTTGATGAAATCATGGTGAACGTAA
GCCATTTAGCAGATGAAATTGAAAGCTATTTTAGAGATGGCCAAGGTTTTGGCGTGGATATTGCGTACTCCTTTGAAGGG
CGAATTGAAGACGGCATGCTGATCGGAGATGCCGTTGGTTCAGCAGGAGGGATGAAGCGGATTCAGGACTTTTCGCCATT
TTTTGACGATACCTTTATTGTGCTCTGTGGTGATGCCCTGATTGATCTAGATTTAACGGCTGCAGTGGAATGGCATCGAC
AAAAAGGCTCCATGGCCACCATCATTATGAAAACCGTCGATCCAAATGATGTTTCTAGCTATGGGGTTGTCGTCACGGAT
GAAGAAGGCCGAATCAAATCTTTCCAGGAGAAACCTACGGTTGATGAGGCCCTCAGCAACACCATCAACACAGGTATTTA
TATTTTTGAGCCTGAGATTCTAGATTTGATTCCCTCTGGAGAAGAGTTTGATATTGGGGGGGATCTTTTTCCCAAACTGG
TGTCGATGAATTTACCGTTTTATGGCGTTGCCATGGATTTTCAATGGGTGGATATTGGCAAGGTTCCCGATTATTGGCAT
GCCATTCGTAGCGTATTGAAAGGCGAGGTCAAAAATGTGGCGATTCCAGGTCGTGAAGTGAAGCCTGGTATCTATACTGG
CCTGAACGTTGATGTCAACTGGGATAAGGTCGATATTCAAGGTCCGGTATACATTGGCGGCATGACTCGTATTGATGACG
GGGTAAAAATTATTGGCCCAACCATGATTGGACCGAACTGTCATATTTGTAAGGGCGCAACGGTAGACAACAGCGTGATC
TTCGAGTACTCTCGCCTGGGTCCTGAAGCGAATCTAGTCGATAAGTTGGTGTTTGGACGCTACTGTGTGGATAAAACAGG
TGTATCCCTCGATGTTCGCACAGCCGCTTTGGATTGGCTGATTACGGATGTTCGCCAAGATGCTCATGTTCCCGCACCTG
TGATGATCTAA

Upstream 100 bases:

>100_bases
AATGCCCTAGCAATCCGATAGAAAGCTAGCGCATGAACCTCTGAGAATCTAATGCAATATTTCGATCAGTTACTAGTTCT
CTATACACAAACTATTTGAT

Downstream 100 bases:

>100_bases
GCTGGTACTTCTGCTCACAAAAGGACCAGCACAGTCCTTGGTCTTGATCTTCCTCAGAAGATTTTGACCGAATTTAGAAC
TATCGAGATAATCGCTTGTT

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVDLLRQHGFDEIMVNVSHLADEIESYFRDGQGFGVDIAYSFEG
RIEDGMLIGDAVGSAGGMKRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSMATIIMKTVDPNDVSSYGVVVTD
EEGRIKSFQEKPTVDEALSNTINTGIYIFEPEILDLIPSGEEFDIGGDLFPKLVSMNLPFYGVAMDFQWVDIGKVPDYWH
AIRSVLKGEVKNVAIPGREVKPGIYTGLNVDVNWDKVDIQGPVYIGGMTRIDDGVKIIGPTMIGPNCHICKGATVDNSVI
FEYSRLGPEANLVDKLVFGRYCVDKTGVSLDVRTAALDWLITDVRQDAHVPAPVMI

Sequences:

>Translated_376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVDLLRQHGFDEIMVNVSHLADEIESYFRDGQGFGVDIAYSFEG
RIEDGMLIGDAVGSAGGMKRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSMATIIMKTVDPNDVSSYGVVVTD
EEGRIKSFQEKPTVDEALSNTINTGIYIFEPEILDLIPSGEEFDIGGDLFPKLVSMNLPFYGVAMDFQWVDIGKVPDYWH
AIRSVLKGEVKNVAIPGREVKPGIYTGLNVDVNWDKVDIQGPVYIGGMTRIDDGVKIIGPTMIGPNCHICKGATVDNSVI
FEYSRLGPEANLVDKLVFGRYCVDKTGVSLDVRTAALDWLITDVRQDAHVPAPVMI
>Mature_376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVDLLRQHGFDEIMVNVSHLADEIESYFRDGQGFGVDIAYSFEG
RIEDGMLIGDAVGSAGGMKRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSMATIIMKTVDPNDVSSYGVVVTD
EEGRIKSFQEKPTVDEALSNTINTGIYIFEPEILDLIPSGEEFDIGGDLFPKLVSMNLPFYGVAMDFQWVDIGKVPDYWH
AIRSVLKGEVKNVAIPGREVKPGIYTGLNVDVNWDKVDIQGPVYIGGMTRIDDGVKIIGPTMIGPNCHICKGATVDNSVI
FEYSRLGPEANLVDKLVFGRYCVDKTGVSLDVRTAALDWLITDVRQDAHVPAPVMI

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:
GO:0009058: Mannose-1-phosphate guanylyltransferase
GO:0016740: Mannose-1-phosphate guanylyltransferase
GO:0016779: Mannose-1-phosphate guanylyltransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=362, Percent_Identity=27.6243093922652, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI11761619, Length=362, Percent_Identity=27.6243093922652, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI31881779, Length=356, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI45447090, Length=356, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788351, Length=240, Percent_Identity=27.9166666666667, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789837, Length=268, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790224, Length=245, Percent_Identity=26.530612244898, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=350, Percent_Identity=31.4285714285714, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17509979, Length=356, Percent_Identity=28.0898876404494, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509981, Length=346, Percent_Identity=28.0346820809249, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=350, Percent_Identity=28, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355443, Length=322, Percent_Identity=29.5031055900621, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644084, Length=322, Percent_Identity=29.5031055900621, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653912, Length=208, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 41457; Mature: 41457

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVDLLRQHGFDEIMVNVSHLADEI
CCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHH
ESYFRDGQGFGVDIAYSFEGRIEDGMLIGDAVGSAGGMKRIQDFSPFFDDTFIVLCGDAL
HHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCEEEEEECCEE
IDLDLTAAVEWHRQKGSMATIIMKTVDPNDVSSYGVVVTDEEGRIKSFQEKPTVDEALSN
EEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHCCCCCCCHHHHHHH
TINTGIYIFEPEILDLIPSGEEFDIGGDLFPKLVSMNLPFYGVAMDFQWVDIGKVPDYWH
HHHCCEEEECCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHH
AIRSVLKGEVKNVAIPGREVKPGIYTGLNVDVNWDKVDIQGPVYIGGMTRIDDGVKIIGP
HHHHHHHCCHHEEECCCCCCCCCEEECEEEEECCCEEEECCCEEECCCEECCCCEEEEEC
TMIGPNCHICKGATVDNSVIFEYSRLGPEANLVDKLVFGRYCVDKTGVSLDVRTAALDWL
EEECCCCEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
ITDVRQDAHVPAPVMI
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVDLLRQHGFDEIMVNVSHLADEI
CCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHH
ESYFRDGQGFGVDIAYSFEGRIEDGMLIGDAVGSAGGMKRIQDFSPFFDDTFIVLCGDAL
HHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCEEEEEECCEE
IDLDLTAAVEWHRQKGSMATIIMKTVDPNDVSSYGVVVTDEEGRIKSFQEKPTVDEALSN
EEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHCCCCCCCHHHHHHH
TINTGIYIFEPEILDLIPSGEEFDIGGDLFPKLVSMNLPFYGVAMDFQWVDIGKVPDYWH
HHHCCEEEECCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHH
AIRSVLKGEVKNVAIPGREVKPGIYTGLNVDVNWDKVDIQGPVYIGGMTRIDDGVKIIGP
HHHHHHHCCHHEEECCCCCCCCCEEECEEEEECCCEEEECCCEEECCCEECCCCEEEEEC
TMIGPNCHICKGATVDNSVIFEYSRLGPEANLVDKLVFGRYCVDKTGVSLDVRTAALDWL
EEECCCCEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
ITDVRQDAHVPAPVMI
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]