Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 158335564

GI number: 158335564

Start: 2420200

End: 2420763

Strand: Reverse

Name: adk [H]

Synonym: AM1_2414

Alternate gene names: 158335564

Gene position: 2420763-2420200 (Counterclockwise)

Preceding gene: 158335566

Following gene: 158335563

Centisome position: 37.22

GC content: 49.65

Gene sequence:

>564_bases
ATGCGACTTGTATTTCTCGGCCCGCCCGGTTCTGGTAAAAGTACACAAGCTCAAGCAGGGGCTGCGCGTTGGCAGATTCC
CAGTATTTCGACAGGTGATTTACTCCGCGATGCGATCGCAACCCAATCTGACTTAGGTAAACAAGCCCAAACTCATGTGG
AAGCGGGTGAACTCGTTCCAGATACCTTAATGGTAGGTTTGATGCGGGAAAGCTTTGGGTCACCCGCCACCCAGAATGGT
TGGATTTTGGATGGTTTTCCCCGGAATCTCGCTCAAACCCAGGCGCTGGATACCTTACTCCAAATTATGGGCCAGCTCTA
TGGGCAAGTCGTGTATTTTGAAACCCCCGAAGATTTATTAATCGAGCGAATGCTGAAGCGAGGTCGGCAGGATGATAGTG
AAGATCTGATCCGACAGCGCTTACAGATTTACAACGACCAAACCACTCCGCTGATTGACTTTTACCGCCGTCGCCAATGT
TTGATTGAAATTGATGGGAGTCGCCCGGAGTCAGAAATTACGGATGAGATCGCATCAGCATTACAACCCTTAGTCAGCGT
TTGA

Upstream 100 bases:

>100_bases
AGAATATGAGACCACATAGCTGTTGAGTTGGTGTATCCCTTTCTTGTGGATGCTGGCTCCTTGGCCATTAGCGACTGTGT
TGTTATTCCCCACTAAAACG

Downstream 100 bases:

>100_bases
ACAACGACCGACTATAATAGGTAAAAATACTTAACTATAAGCGGCAACTTCAAGAATACTGGTTGGCCTCTAACCTTGAT
TCTCGACCTTGAGATCAGCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRLVFLGPPGSGKSTQAQAGAARWQIPSISTGDLLRDAIATQSDLGKQAQTHVEAGELVPDTLMVGLMRESFGSPATQNG
WILDGFPRNLAQTQALDTLLQIMGQLYGQVVYFETPEDLLIERMLKRGRQDDSEDLIRQRLQIYNDQTTPLIDFYRRRQC
LIEIDGSRPESEITDEIASALQPLVSV

Sequences:

>Translated_187_residues
MRLVFLGPPGSGKSTQAQAGAARWQIPSISTGDLLRDAIATQSDLGKQAQTHVEAGELVPDTLMVGLMRESFGSPATQNG
WILDGFPRNLAQTQALDTLLQIMGQLYGQVVYFETPEDLLIERMLKRGRQDDSEDLIRQRLQIYNDQTTPLIDFYRRRQC
LIEIDGSRPESEITDEIASALQPLVSV
>Mature_187_residues
MRLVFLGPPGSGKSTQAQAGAARWQIPSISTGDLLRDAIATQSDLGKQAQTHVEAGELVPDTLMVGLMRESFGSPATQNG
WILDGFPRNLAQTQALDTLLQIMGQLYGQVVYFETPEDLLIERMLKRGRQDDSEDLIRQRLQIYNDQTTPLIDFYRRRQC
LIEIDGSRPESEITDEIASALQPLVSV

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:
GO:0000166: Adenylate kinase 2
GO:0004017: Adenylate kinase 2
GO:0005524: Adenylate kinase 2
GO:0005737: Adenylate kinase 2
GO:0006139: Adenylate kinase 2
GO:0009165: Adenylate kinase 2
GO:0016301: Adenylate kinase 2
GO:0016310: Adenylate kinase 2
GO:0016740: Adenylate kinase 2
GO:0016776: Adenylate kinase 2
GO:0019201: Adenylate kinase 2
GO:0019205: Adenylate kinase 2
GO:0046939: Adenylate kinase 2

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=34.1013824884793, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=34.4339622641509, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502011, Length=192, Percent_Identity=29.1666666666667, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=30.4568527918782, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=30.1075268817204, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=30.9278350515464, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=30.9278350515464, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=30.9278350515464, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=30.9278350515464, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI28144899, Length=192, Percent_Identity=27.0833333333333, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI28144897, Length=192, Percent_Identity=27.0833333333333, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=33.0708661417323, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI209915597, Length=128, Percent_Identity=29.6875, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=32.7188940092166, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=32.2115384615385, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=169, Percent_Identity=33.7278106508876, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=172, Percent_Identity=33.7209302325581, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=30.8108108108108, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=30.9859154929577, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=31.2820512820513, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=31.9047619047619, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=28.1407035175879, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=28.1407035175879, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=30.2702702702703, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=30.2702702702703, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=28.1914893617021, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=28.1914893617021, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20803; Mature: 20803

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVFLGPPGSGKSTQAQAGAARWQIPSISTGDLLRDAIATQSDLGKQAQTHVEAGELVP
CEEEEECCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTLMVGLMRESFGSPATQNGWILDGFPRNLAQTQALDTLLQIMGQLYGQVVYFETPEDLL
HHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHH
IERMLKRGRQDDSEDLIRQRLQIYNDQTTPLIDFYRRRQCLIEIDGSRPESEITDEIASA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
LQPLVSV
HHHHHCC
>Mature Secondary Structure
MRLVFLGPPGSGKSTQAQAGAARWQIPSISTGDLLRDAIATQSDLGKQAQTHVEAGELVP
CEEEEECCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTLMVGLMRESFGSPATQNGWILDGFPRNLAQTQALDTLLQIMGQLYGQVVYFETPEDLL
HHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHH
IERMLKRGRQDDSEDLIRQRLQIYNDQTTPLIDFYRRRQCLIEIDGSRPESEITDEIASA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHH
LQPLVSV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA