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The map label for this gene is tktA [H]

Identifier: 158335563

GI number: 158335563

Start: 2418068

End: 2419969

Strand: Reverse

Name: tktA [H]

Synonym: AM1_2413

Alternate gene names: 158335563

Gene position: 2419969-2418068 (Counterclockwise)

Preceding gene: 158335564

Following gene: 158335562

Centisome position: 37.21

GC content: 52.0

Gene sequence:

>1902_bases
ATGACAACATTCCCGATTGATTTAAAGGCCTATAAACCGCTTACCCTGGACGCTAGCAATCCCACCCTCACCCCGGAGCA
ACGGGAGACCCTCAAATCGAATATTCAGCTTTGCCGTGATGCCATTGTCTTTTTTACCGCCACGGGGGCAGCCCGAGGTG
TGGGTGGACATACCGGTGGCCCCTACGACACGGTTCCCGAAGTGATGATTTTGGATGCGCTCTTTCGGGGCAGTGCTGAC
AAGTATGTTCCGATCTTTTTTGACGAAGCTGGGCACCGAGTCGCGACGCAATACTTGATGTCTACTCTAGAAGGCTCCTT
ACCTGCCGAGCAGTTGATGAGTTATCGGGCTGCCAACTCCACCTTGCCTGGTCACCCCGAACTGGGTCTCACCCCTGGGG
TTAAGTTCAGCTCCGGTCGTTTGGGACATATGTGGCCCTATGTGAATGGCGTTGCCCTCGCAAATCCTGGTAAAACAGCC
TTCTGTCTTGGGTCTGATGGTTCTCAGCAAGAAGGAAATGATGCAGAAGCGGCCCGCCTAGCCGTTGCCCAGCAGATTAA
CGTCAAGCTGCTGATTGATGATAATGACATCACCATTGCCGGTAGCCCTTCTGACTATCTACCTGGCTTTAGTGTCAAAA
AGACTTTGGAAGGTCATGGCCTCAAAGTTCTAGAAGGCGATGGCGAAGATATTGATGGCCTCTACGCTCGCATTTGTGAA
GCGATTAACACCCCCGGTCCCGTGGCCGTTATCAACAAGCGGGCCATGTGTGTGGGGATCGACGGTCTAGAAGGATCTAA
CCATGGTCATGACGTGATCTCTGTGGATGCCGCCCTTAAGTATCTAGAGGCTCGCGGTCATTCTGATGCGGTTTCCAATC
TGAAGAGTGTGGTTAAGCCTAGCCAGGACTATACGTTCCTCGGGGCTTCTGAGAAGTACGACTCCAACCGGAACGTCTTC
GGTGATGCGGTGGTAGAAGTCCTCAGCGGCATGAGCGAAGCCGACCGTAAGGCTAAGGTGCTCGTCGTGGATAGCGACCT
GGAAGGCTCCTGTGGTCTCCATAAAATTCGAGCTGCTAATCCTGAAATTTTTATCAGTGGTGGGATTCAAGAGCGAGGCA
ACCTGTCTGCTGCTGCTGGTTTCGGCATGGCTGCAGGCAAGCAGGGCATCTTTGCCACCTTTAGTGCCTTTTTGGAGATG
TGTATCTCTGAGATCACCATGGCTCGCTTGAACAAGTCCAACTTGCTCTGTCACTTCTCCCATGCGGGCATTGACGATAT
GGCCGATAACACCTGCCACTTCGGTATTAACAATATGTTTGCCGATAATGGCTTGGATGATGGTTATGAGACTCGCCTCT
ATTTCCCTGCCGATGCCAACCAAATGAAGGCCTGTGTAAAGTCGGTTTTCGATAATTCGGGTCTCCGGTTTATCTTCTCT
ACTCGCTCTAAGGTACCCCTCCTGACAGACGCTAATGGCGGTGAGCTGTATGCAGGCAATTACACCTTTACCCCTGGCAA
GGACGAAGTGGTACGAGAAGGAACAGCAGGCTATATTGTCAGCTTTGGTGAAGCCCTCTATCGGTCTTTGGATGCGGTTG
AGCGTCTGAAGAAGGAAGGCATTGATGTGGGTCTCATCAACAAGTCCACCCTCAATGTCGTCGACGAAGACATGATGAAG
AAGATTGGCGCAGCGCCCTTTGTGGTGGTCGTTGAATCCTTTAACCGTCGGACTGGATTAGGTAGCCGCTTCGGTTCTTG
GCTGCTGGAGCGAGGACTATCTCCTAAGTTTGCTTACTTAGGCACCCATGAAGAAGGCTGCGGCGGTCTTTGGGAGCAAT
TCCCTCATCAAGGGATTGACCCCGTTGGCATTATGAAGACCGTCAAGTCTCTCGCTAGCTAA

Upstream 100 bases:

>100_bases
CGGTACCCAAAAACGTCTGGAGGGCTTCAGACAAAATGGTACGATAGCCAGGCTAGCCCGTTATAACTCTTCACATTGAC
CCATTTAAGGAACAGCTTCT

Downstream 100 bases:

>100_bases
GCTTAATTTGATTAACTCTTGGAATATCTCCCTGACGGATGTTGGGGAGATATTTTTTTCCCTAGGACGTACCGCATATT
TAGAGATTCAAGGATAGATT

Product: transketolase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MTTFPIDLKAYKPLTLDASNPTLTPEQRETLKSNIQLCRDAIVFFTATGAARGVGGHTGGPYDTVPEVMILDALFRGSAD
KYVPIFFDEAGHRVATQYLMSTLEGSLPAEQLMSYRAANSTLPGHPELGLTPGVKFSSGRLGHMWPYVNGVALANPGKTA
FCLGSDGSQQEGNDAEAARLAVAQQINVKLLIDDNDITIAGSPSDYLPGFSVKKTLEGHGLKVLEGDGEDIDGLYARICE
AINTPGPVAVINKRAMCVGIDGLEGSNHGHDVISVDAALKYLEARGHSDAVSNLKSVVKPSQDYTFLGASEKYDSNRNVF
GDAVVEVLSGMSEADRKAKVLVVDSDLEGSCGLHKIRAANPEIFISGGIQERGNLSAAAGFGMAAGKQGIFATFSAFLEM
CISEITMARLNKSNLLCHFSHAGIDDMADNTCHFGINNMFADNGLDDGYETRLYFPADANQMKACVKSVFDNSGLRFIFS
TRSKVPLLTDANGGELYAGNYTFTPGKDEVVREGTAGYIVSFGEALYRSLDAVERLKKEGIDVGLINKSTLNVVDEDMMK
KIGAAPFVVVVESFNRRTGLGSRFGSWLLERGLSPKFAYLGTHEEGCGGLWEQFPHQGIDPVGIMKTVKSLAS

Sequences:

>Translated_633_residues
MTTFPIDLKAYKPLTLDASNPTLTPEQRETLKSNIQLCRDAIVFFTATGAARGVGGHTGGPYDTVPEVMILDALFRGSAD
KYVPIFFDEAGHRVATQYLMSTLEGSLPAEQLMSYRAANSTLPGHPELGLTPGVKFSSGRLGHMWPYVNGVALANPGKTA
FCLGSDGSQQEGNDAEAARLAVAQQINVKLLIDDNDITIAGSPSDYLPGFSVKKTLEGHGLKVLEGDGEDIDGLYARICE
AINTPGPVAVINKRAMCVGIDGLEGSNHGHDVISVDAALKYLEARGHSDAVSNLKSVVKPSQDYTFLGASEKYDSNRNVF
GDAVVEVLSGMSEADRKAKVLVVDSDLEGSCGLHKIRAANPEIFISGGIQERGNLSAAAGFGMAAGKQGIFATFSAFLEM
CISEITMARLNKSNLLCHFSHAGIDDMADNTCHFGINNMFADNGLDDGYETRLYFPADANQMKACVKSVFDNSGLRFIFS
TRSKVPLLTDANGGELYAGNYTFTPGKDEVVREGTAGYIVSFGEALYRSLDAVERLKKEGIDVGLINKSTLNVVDEDMMK
KIGAAPFVVVVESFNRRTGLGSRFGSWLLERGLSPKFAYLGTHEEGCGGLWEQFPHQGIDPVGIMKTVKSLAS
>Mature_632_residues
TTFPIDLKAYKPLTLDASNPTLTPEQRETLKSNIQLCRDAIVFFTATGAARGVGGHTGGPYDTVPEVMILDALFRGSADK
YVPIFFDEAGHRVATQYLMSTLEGSLPAEQLMSYRAANSTLPGHPELGLTPGVKFSSGRLGHMWPYVNGVALANPGKTAF
CLGSDGSQQEGNDAEAARLAVAQQINVKLLIDDNDITIAGSPSDYLPGFSVKKTLEGHGLKVLEGDGEDIDGLYARICEA
INTPGPVAVINKRAMCVGIDGLEGSNHGHDVISVDAALKYLEARGHSDAVSNLKSVVKPSQDYTFLGASEKYDSNRNVFG
DAVVEVLSGMSEADRKAKVLVVDSDLEGSCGLHKIRAANPEIFISGGIQERGNLSAAAGFGMAAGKQGIFATFSAFLEMC
ISEITMARLNKSNLLCHFSHAGIDDMADNTCHFGINNMFADNGLDDGYETRLYFPADANQMKACVKSVFDNSGLRFIFST
RSKVPLLTDANGGELYAGNYTFTPGKDEVVREGTAGYIVSFGEALYRSLDAVERLKKEGIDVGLINKSTLNVVDEDMMKK
IGAAPFVVVVESFNRRTGLGSRFGSWLLERGLSPKFAYLGTHEEGCGGLWEQFPHQGIDPVGIMKTVKSLAS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:
GO:0003824: Transketolase, putative
GO:0008152: Transketolase, putative
GO:0004802: Transketolase
GO:0016740: Transketolase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=501, Percent_Identity=22.1556886227545, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4507521, Length=501, Percent_Identity=22.1556886227545, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI133778974, Length=516, Percent_Identity=22.8682170542636, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI225637459, Length=464, Percent_Identity=21.1206896551724, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI225637463, Length=464, Percent_Identity=21.1206896551724, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI225637461, Length=464, Percent_Identity=21.1206896551724, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=535, Percent_Identity=24.8598130841122, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325331, Length=303, Percent_Identity=30.3630363036304, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666278, Length=622, Percent_Identity=24.4372990353698, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551847, Length=549, Percent_Identity=24.2258652094718, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550715, Length=549, Percent_Identity=24.2258652094718, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645119, Length=549, Percent_Identity=24.2258652094718, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67854; Mature: 67723

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFPIDLKAYKPLTLDASNPTLTPEQRETLKSNIQLCRDAIVFFTATGAARGVGGHTGG
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
PYDTVPEVMILDALFRGSADKYVPIFFDEAGHRVATQYLMSTLEGSLPAEQLMSYRAANS
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TLPGHPELGLTPGVKFSSGRLGHMWPYVNGVALANPGKTAFCLGSDGSQQEGNDAEAARL
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHH
AVAQQINVKLLIDDNDITIAGSPSDYLPGFSVKKTLEGHGLKVLEGDGEDIDGLYARICE
HHHHCCCEEEEEECCCEEEECCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHH
AINTPGPVAVINKRAMCVGIDGLEGSNHGHDVISVDAALKYLEARGHSDAVSNLKSVVKP
HHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCC
SQDYTFLGASEKYDSNRNVFGDAVVEVLSGMSEADRKAKVLVVDSDLEGSCGLHKIRAAN
CCCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCEEEECCC
PEIFISGGIQERGNLSAAAGFGMAAGKQGIFATFSAFLEMCISEITMARLNKSNLLCHFS
CCEEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
HAGIDDMADNTCHFGINNMFADNGLDDGYETRLYFPADANQMKACVKSVFDNSGLRFIFS
CCCCCHHCCCCEECCCCHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEE
TRSKVPLLTDANGGELYAGNYTFTPGKDEVVREGTAGYIVSFGEALYRSLDAVERLKKEG
CCCCCCEEEECCCCEEEECCEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IDVGLINKSTLNVVDEDMMKKIGAAPFVVVVESFNRRTGLGSRFGSWLLERGLSPKFAYL
CCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
GTHEEGCGGLWEQFPHQGIDPVGIMKTVKSLAS
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TTFPIDLKAYKPLTLDASNPTLTPEQRETLKSNIQLCRDAIVFFTATGAARGVGGHTGG
CCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
PYDTVPEVMILDALFRGSADKYVPIFFDEAGHRVATQYLMSTLEGSLPAEQLMSYRAANS
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TLPGHPELGLTPGVKFSSGRLGHMWPYVNGVALANPGKTAFCLGSDGSQQEGNDAEAARL
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHH
AVAQQINVKLLIDDNDITIAGSPSDYLPGFSVKKTLEGHGLKVLEGDGEDIDGLYARICE
HHHHCCCEEEEEECCCEEEECCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHH
AINTPGPVAVINKRAMCVGIDGLEGSNHGHDVISVDAALKYLEARGHSDAVSNLKSVVKP
HHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCC
SQDYTFLGASEKYDSNRNVFGDAVVEVLSGMSEADRKAKVLVVDSDLEGSCGLHKIRAAN
CCCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCEEEECCC
PEIFISGGIQERGNLSAAAGFGMAAGKQGIFATFSAFLEMCISEITMARLNKSNLLCHFS
CCEEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
HAGIDDMADNTCHFGINNMFADNGLDDGYETRLYFPADANQMKACVKSVFDNSGLRFIFS
CCCCCHHCCCCEECCCCHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEE
TRSKVPLLTDANGGELYAGNYTFTPGKDEVVREGTAGYIVSFGEALYRSLDAVERLKKEG
CCCCCCEEEECCCCEEEECCEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IDVGLINKSTLNVVDEDMMKKIGAAPFVVVVESFNRRTGLGSRFGSWLLERGLSPKFAYL
CCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEE
GTHEEGCGGLWEQFPHQGIDPVGIMKTVKSLAS
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA