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The map label for this gene is clpP [H]

Identifier: 158335482

GI number: 158335482

Start: 2334430

End: 2335026

Strand: Reverse

Name: clpP [H]

Synonym: AM1_2330

Alternate gene names: 158335482

Gene position: 2335026-2334430 (Counterclockwise)

Preceding gene: 158335483

Following gene: 158335478

Centisome position: 35.9

GC content: 46.9

Gene sequence:

>597_bases
ATGCCTATTGGTGTTCCTAGTGTTCCCTACCGTATTCCTGGCAGTCCCTATGAACGCTGGGTGGATATTTATACCCGTTT
GAGCCAAGAAAGAATCATTTTTCTTGGTCAGGAAGTAACGGATGGTCTAGCCAATCAAATTGTGGCTTTTCTCCTGTATT
TGGATTCTGAAGATCCCAGTAAGCCGATTTCCATCTATATCAACTCGCCGGGTGGTTCAGTGACTGCTGGATTGGCTATT
TATGACACCATGCAGCATATTAAGTCAGAAGTCGCGACCATCTGTGTTGGTCTAGCGGCGTCTATGGGCTCGTTTCTACT
GGCTGCGGGCTCTCCTGGTAAGCGTTTGGCGCTTCCCCACTCCCGAATTATGATTCACCAACCCTCTGGTGGAGCCCGTG
GACAAGCTTCTGATATTGAAATCGAAGCGAAAGAAATCATTCGCGTGCGTCGGCAGTTGAATGATATCTATGCCGCGAGA
ACAGCGCAACCCTTGGAAAAAATTGAAAAAGACATGGATCGCGACTTCTTTATGTCTGCCCATGAGGCTTTAGAATATGG
TCTGATTGACCAAGTGATTGAAGAAAGACCTGCTTAA

Upstream 100 bases:

>100_bases
TGATTGATCGCGTGTTGGCTAGCCAAAAAGAATTACCCACGCCAATGCCCGTCTAAGAAATGAGTCAACCTGAGTAGTAG
CAAAAAGAGAGTTATCGACT

Downstream 100 bases:

>100_bases
CCGCATCTCAATCCATTATTTTTGTCGAGTTTGGCAGTATCTAGAAGAGATGAGCTGCCAGATTTTTTAATTAAGACAGG
TATAGCAGCAAGGCTTTTTC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MPIGVPSVPYRIPGSPYERWVDIYTRLSQERIIFLGQEVTDGLANQIVAFLLYLDSEDPSKPISIYINSPGGSVTAGLAI
YDTMQHIKSEVATICVGLAASMGSFLLAAGSPGKRLALPHSRIMIHQPSGGARGQASDIEIEAKEIIRVRRQLNDIYAAR
TAQPLEKIEKDMDRDFFMSAHEALEYGLIDQVIEERPA

Sequences:

>Translated_198_residues
MPIGVPSVPYRIPGSPYERWVDIYTRLSQERIIFLGQEVTDGLANQIVAFLLYLDSEDPSKPISIYINSPGGSVTAGLAI
YDTMQHIKSEVATICVGLAASMGSFLLAAGSPGKRLALPHSRIMIHQPSGGARGQASDIEIEAKEIIRVRRQLNDIYAAR
TAQPLEKIEKDMDRDFFMSAHEALEYGLIDQVIEERPA
>Mature_197_residues
PIGVPSVPYRIPGSPYERWVDIYTRLSQERIIFLGQEVTDGLANQIVAFLLYLDSEDPSKPISIYINSPGGSVTAGLAIY
DTMQHIKSEVATICVGLAASMGSFLLAAGSPGKRLALPHSRIMIHQPSGGARGQASDIEIEAKEIIRVRRQLNDIYAART
AQPLEKIEKDMDRDFFMSAHEALEYGLIDQVIEERPA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:
GO:0000166: ATP-dependent Clp protease proteolytic subunit 2
GO:0004252: ATP-dependent Clp protease proteolytic subunit 2
GO:0005524: ATP-dependent Clp protease proteolytic subunit 2
GO:0005737: ATP-dependent Clp protease proteolytic subunit 2
GO:0006508: ATP-dependent Clp protease proteolytic subunit 2
GO:0008233: ATP-dependent Clp protease proteolytic subunit 2
GO:0008236: ATP-dependent Clp protease proteolytic subunit 2
GO:0016787: ATP-dependent Clp protease proteolytic subunit 2

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=180, Percent_Identity=58.3333333333333, Blast_Score=214, Evalue=4e-56,
Organism=Escherichia coli, GI1786641, Length=179, Percent_Identity=58.659217877095, Blast_Score=227, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17538017, Length=175, Percent_Identity=58.8571428571429, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129427, Length=180, Percent_Identity=57.2222222222222, Blast_Score=213, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21813; Mature: 21682

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGVPSVPYRIPGSPYERWVDIYTRLSQERIIFLGQEVTDGLANQIVAFLLYLDSEDPS
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCC
KPISIYINSPGGSVTAGLAIYDTMQHIKSEVATICVGLAASMGSFLLAAGSPGKRLALPH
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCC
SRIMIHQPSGGARGQASDIEIEAKEIIRVRRQLNDIYAARTAQPLEKIEKDMDRDFFMSA
CEEEEECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
HEALEYGLIDQVIEERPA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIGVPSVPYRIPGSPYERWVDIYTRLSQERIIFLGQEVTDGLANQIVAFLLYLDSEDPS
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCC
KPISIYINSPGGSVTAGLAIYDTMQHIKSEVATICVGLAASMGSFLLAAGSPGKRLALPH
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCC
SRIMIHQPSGGARGQASDIEIEAKEIIRVRRQLNDIYAARTAQPLEKIEKDMDRDFFMSA
CEEEEECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
HEALEYGLIDQVIEERPA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]