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The map label for this gene is bioF [C]

Identifier: 158335448

GI number: 158335448

Start: 2294575

End: 2295759

Strand: Direct

Name: bioF [C]

Synonym: AM1_2296

Alternate gene names: 158335448

Gene position: 2294575-2295759 (Clockwise)

Preceding gene: 158335444

Following gene: 158335452

Centisome position: 35.28

GC content: 50.97

Gene sequence:

>1185_bases
ATGGCTGCGTATGATTGGATCGAGTCAGCGTTAGCCACAGTTCACAAAGCGAATTGGTATCGCTCGGTCAAAACCATGAG
CAGCCCAGGTCCAACGGCTGTACTCAATGGACAAACAGTGATCAATTTTGCCAGTAATGATTATCTCGGTTTAGCCGGGG
ATTCAAGGCTAGCTGAAGCTGCGATTGCAGCTATCAATACCTATGGAACCGGCAGTACAGGGTCGCGGTTGCTCAGCGGT
CATCGAATGATTCATGAGCAGTTGGAGCGTGCGATCGCAACCTGGAAACAGACGGAAACGGCTATTGTCTACAGCTCTGG
CTATCTCGCCAATATCGGTACGATTACGGCCCTCGTCAATAAACGGGATTTAATTCTGGCGGATGCCTACAACCATGCCA
GCCTTAAGAATGGGGCGCGGTTGAGTGGAGCCACCATCCATGAATTTGGTCATGCAAATGTCACAGAACTACAAACCCTA
CTAGAAACTCATCGTTCTCACCATCGCCGTTGCCTTTTGGTCACCGATAGCGTCTTTAGTATGGATGGTGATCTATGCCC
GCTGCCAGAACTGATTGCCCTGGCTGAACAGTATGACTGCATGCTTTTGATTGACGAAGCTCACGGGACTGGGGTTTTAG
GAAAAACGGGAGCAGGCTGTGTGGAACATTTTGGCTGTCGCGATGCGGAGCTGATTCAAATGGGGACGCTCAGTAAAGCT
CTCGGCAGTTTAGGGGGCTATGTGGCGGGTTCCGCTAGTTTGATTGATTATCTCCGCAATCGATCTTCAAGCTGGATTTA
TACGACGGGACTATCTCCTGCGGATACGGCGGCGGCGCTAGCGGCAGTGGAAATTATTCGGGAGGGAAGTGAGTTGCGAT
CTCAACTTTGGCAACGGGTCACTCAACTCAAGCAAGCCTTAACCACCCACCTGGCCCCTGAAGACGAACATCAAACCATG
CAGCTCTTACCCTCAGAGTCACCGATTCTCTGTGTGCAAATGCCTACACCTGCAGCCGTTTTGACGGCCAGCCAGCAACT
TCTTGACCAAGGAATTTTTGCCCCAGCCATCCGCCCACCCACTGTTCCTACTAGCCGAATTCGGATTTCGATAATGGCCA
CTCATCAAGCTGTACAAATTGATCAGCTTATTGTTGCCTTAAGCGAGGTAGCTCAGGGCAGTTGA

Upstream 100 bases:

>100_bases
TCACCAAGCGTTACATTTCGCAAAGAGACTCGTTACATTTTGAAAAATATTATGAAGGACTGCTCCGAGTGTTGAACTAC
CTGCTGCAAGAGGGGCTGTA

Downstream 100 bases:

>100_bases
GAACTTTCATACGCAGGCTTACTGATATTTTGAGTGAGATAATTTGCGTATTCTGCTTACAATTCATGATCACTAGGATC
TGCCTCAGGACGCTTGGCGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAAYDWIESALATVHKANWYRSVKTMSSPGPTAVLNGQTVINFASNDYLGLAGDSRLAEAAIAAINTYGTGSTGSRLLSG
HRMIHEQLERAIATWKQTETAIVYSSGYLANIGTITALVNKRDLILADAYNHASLKNGARLSGATIHEFGHANVTELQTL
LETHRSHHRRCLLVTDSVFSMDGDLCPLPELIALAEQYDCMLLIDEAHGTGVLGKTGAGCVEHFGCRDAELIQMGTLSKA
LGSLGGYVAGSASLIDYLRNRSSSWIYTTGLSPADTAAALAAVEIIREGSELRSQLWQRVTQLKQALTTHLAPEDEHQTM
QLLPSESPILCVQMPTPAAVLTASQQLLDQGIFAPAIRPPTVPTSRIRISIMATHQAVQIDQLIVALSEVAQGS

Sequences:

>Translated_394_residues
MAAYDWIESALATVHKANWYRSVKTMSSPGPTAVLNGQTVINFASNDYLGLAGDSRLAEAAIAAINTYGTGSTGSRLLSG
HRMIHEQLERAIATWKQTETAIVYSSGYLANIGTITALVNKRDLILADAYNHASLKNGARLSGATIHEFGHANVTELQTL
LETHRSHHRRCLLVTDSVFSMDGDLCPLPELIALAEQYDCMLLIDEAHGTGVLGKTGAGCVEHFGCRDAELIQMGTLSKA
LGSLGGYVAGSASLIDYLRNRSSSWIYTTGLSPADTAAALAAVEIIREGSELRSQLWQRVTQLKQALTTHLAPEDEHQTM
QLLPSESPILCVQMPTPAAVLTASQQLLDQGIFAPAIRPPTVPTSRIRISIMATHQAVQIDQLIVALSEVAQGS
>Mature_393_residues
AAYDWIESALATVHKANWYRSVKTMSSPGPTAVLNGQTVINFASNDYLGLAGDSRLAEAAIAAINTYGTGSTGSRLLSGH
RMIHEQLERAIATWKQTETAIVYSSGYLANIGTITALVNKRDLILADAYNHASLKNGARLSGATIHEFGHANVTELQTLL
ETHRSHHRRCLLVTDSVFSMDGDLCPLPELIALAEQYDCMLLIDEAHGTGVLGKTGAGCVEHFGCRDAELIQMGTLSKAL
GSLGGYVAGSASLIDYLRNRSSSWIYTTGLSPADTAAALAAVEIIREGSELRSQLWQRVTQLKQALTTHLAPEDEHQTMQ
LLPSESPILCVQMPTPAAVLTASQQLLDQGIFAPAIRPPTVPTSRIRISIMATHQAVQIDQLIVALSEVAQGS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=392, Percent_Identity=33.1632653061224, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI284448556, Length=356, Percent_Identity=34.2696629213483, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4758668, Length=391, Percent_Identity=33.7595907928389, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI119220554, Length=406, Percent_Identity=32.512315270936, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI83977442, Length=352, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977440, Length=352, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977444, Length=352, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4502025, Length=393, Percent_Identity=30.5343511450382, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI40316939, Length=393, Percent_Identity=30.5343511450382, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI5454084, Length=290, Percent_Identity=31.0344827586207, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1790046, Length=395, Percent_Identity=31.1392405063291, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1786993, Length=358, Percent_Identity=34.0782122905028, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=33.6683417085427, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=31.9672131147541, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=386, Percent_Identity=30.3108808290155, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=386, Percent_Identity=30.3108808290155, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=265, Percent_Identity=29.4339622641509, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=265, Percent_Identity=29.4339622641509, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=29.4117647058824, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320438, Length=401, Percent_Identity=30.9226932668329, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323954, Length=312, Percent_Identity=29.8076923076923, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=31.4432989690722, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17137420, Length=356, Percent_Identity=33.7078651685393, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17136286, Length=367, Percent_Identity=28.6103542234332, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24653280, Length=292, Percent_Identity=31.5068493150685, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653276, Length=292, Percent_Identity=31.5068493150685, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653278, Length=292, Percent_Identity=31.5068493150685, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_ACAM1 (B0C205)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516620.1
- ProteinModelPortal:   B0C205
- GeneID:   5681109
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2296
- HOGENOM:   HBG649839
- OMA:   ANWYRSV
- ProtClustDB:   PRK05958
- BioCyc:   AMAR329726:AM1_2296-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 42284; Mature: 42152

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 21-21 BINDING 132-132 BINDING 180-180 BINDING 361-361

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYDWIESALATVHKANWYRSVKTMSSPGPTAVLNGQTVINFASNDYLGLAGDSRLAEA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCCEEEECCCHHHHHH
AIAAINTYGTGSTGSRLLSGHRMIHEQLERAIATWKQTETAIVYSSGYLANIGTITALVN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHC
KRDLILADAYNHASLKNGARLSGATIHEFGHANVTELQTLLETHRSHHRRCLLVTDSVFS
CCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHH
MDGDLCPLPELIALAEQYDCMLLIDEAHGTGVLGKTGAGCVEHFGCRDAELIQMGTLSKA
CCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHH
LGSLGGYVAGSASLIDYLRNRSSSWIYTTGLSPADTAAALAAVEIIREGSELRSQLWQRV
HHHHCCHHCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
TQLKQALTTHLAPEDEHQTMQLLPSESPILCVQMPTPAAVLTASQQLLDQGIFAPAIRPP
HHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
TVPTSRIRISIMATHQAVQIDQLIVALSEVAQGS
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAYDWIESALATVHKANWYRSVKTMSSPGPTAVLNGQTVINFASNDYLGLAGDSRLAEA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCCEEEECCCHHHHHH
AIAAINTYGTGSTGSRLLSGHRMIHEQLERAIATWKQTETAIVYSSGYLANIGTITALVN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHC
KRDLILADAYNHASLKNGARLSGATIHEFGHANVTELQTLLETHRSHHRRCLLVTDSVFS
CCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHH
MDGDLCPLPELIALAEQYDCMLLIDEAHGTGVLGKTGAGCVEHFGCRDAELIQMGTLSKA
CCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHH
LGSLGGYVAGSASLIDYLRNRSSSWIYTTGLSPADTAAALAAVEIIREGSELRSQLWQRV
HHHHCCHHCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
TQLKQALTTHLAPEDEHQTMQLLPSESPILCVQMPTPAAVLTASQQLLDQGIFAPAIRPP
HHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
TVPTSRIRISIMATHQAVQIDQLIVALSEVAQGS
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA