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The map label for this gene is dnaX [H]

Identifier: 158335444

GI number: 158335444

Start: 2287901

End: 2289967

Strand: Direct

Name: dnaX [H]

Synonym: AM1_2292

Alternate gene names: 158335444

Gene position: 2287901-2289967 (Clockwise)

Preceding gene: 158335443

Following gene: 158335448

Centisome position: 35.18

GC content: 52.35

Gene sequence:

>2067_bases
GTGGCTTACGAACCGCTGCATCATAAATATCGTCCCCAAGTCTTTGCAGATTTAGTGGGACAAGATGCGATCGCAACCAC
GTTAACCAATGCGATCGAGTTCGAGCGGATTGCCCCTGCCTATCTCTTTACCGGCCCTCGGGGGACAGGAAAAACCTCCA
GTGCCCGCATCCTCGCCAAATCCCTCAACTGCCTCAATAGCCAGACACCAACCCAAACCCCCTGCGGGACCTGTTCTGTT
TGCCAGGAAGTGGCCCTAGGCACTTCTCTTGATGTCATCGAAATTGATGCTGCCAGCAATACGGGCGTAGACAATATTCG
CGACTTAATCGAACGGGCTCAATTTGCACCGGTTCAATGCCGATTTAAAATTTACTGCCTGGATGAAGTCCATATGCTCA
GCACGGCAGCTTTTAATGCCTTGCTGAAAACATTAGAAGAGCCCCCAGATCGGGTGGTATTTATCCTCGCGACGACGGAT
CCCCAAAGAGTCTTACCCACCATTATTTCTCGCTGCCAACGGTTTGACTTTCGGCGCATTGCCCTAGATCCGATGATTCA
GCACCTCACCCATATTGCTGAACAGGAATCGATTGCCATTACCCCGACGGCGGTAGAACTGATTGCCCAAGTCGCCCAAG
GCGGGTTACGAGATGCAGAAAGTTTGCTCGATCAGCTCAGCTTACTGTCAGGGGAAATTGATAATACTCAGGTCTGGGAT
TTAGTCGGCTCCGTCCCAGAACAGGCGCTCTTAGCCTTACTACAAGCCATTATTGAGCAACAGCCAGCATTGATGGTTGA
GCGCACCCATGCCTTGCTCGATCGCGGTCGAGAACCGTTAACGGTTCTTCAGAATTTAGCGGGCTTTTATCGAGATTTAC
TGATCGCCAAAACGGCCCCTACCCGCAGAGATTTAGTGGCCATCACGGCCCCGACTTGGACCGATTTGTGCCAGCTCGCT
CAGCAGTTTGAGGTCGATGACATTCTGGCCAAGCAACAGCACCTACGCAATTGTGAAACTCAAATCAAGAATTCTACTCA
GCCTCGCTTATGGCTGGAAGTCTCACTTCTGGGTCTGTTGCCAGGGGCCACTCAGTCTACGGATCCACAGCCGATCCTTA
TTCAGATCACATCCCAGCCCTTAGAAACTGCAACTCAGGCACCGGAGCCAGTATCAGCAGGACCTGCTCACCCCGTTCCC
CCGTCGAAAGCCTCTGCCCCCACTCAACCATCTCCCGTTGTTGATACGCCCCAACCCGCTCCTCAAGGAAGTTTCCAGGC
CCCTCCAGTCCCAGAGCCTCAAGTCATCCCCCAACCAGAAGCCCACTCTCCTGAAGCCGAGGACTTACCCAACCCTCTAG
AAGACTTACCAGAGCCTTTAGAAGACTTACCTACACCTCTAGAAGAAACTCCCGACCCCCTGCCTAGTCTGCAGACAGAC
TCCATTCCACACCCAGCACTACCACAACCCGAACCGACGCCTGCTCCCCTCCCACCCCCTTCAGCCCCTCCTGCCCCTGT
ACAAGTTGATCTAACGGAGGTATGGCAGCAGCTTTTACAAAGCCTTAATTTGCCCAGTCGGGCTTTGCTAAAAGAACATG
GCCAACTCCTCTATTGGCAGGGAAGAGAAGTCCGGATTGGGATTCGCAAAACCTTACTTAGACTGGCTCAAGGCAAAGTC
CAAGAACTAGAAGAGACCTTCGAGAAGTGCTTTAATCGCAAAGTTAAAGTCACCTTAAAAGTCCTAACTGAAGAGCAAAT
GCGAGCCAAACCGGCCTCGCCATCCACGTCTTCTGCTCCACCGTCTGTCTCTGCCCCATCTCCCGTCTCCGCTCCACCGC
CCAATATCGCTGCACCTCAGCCAATCGCAACTCCTCCTGCTCCCATTCAGAATGGTCATGCAGCCCCACAAACTGCTCCA
CAAAAACCCTCTGAAGCTCCACCAACCTGGCAAAGTGAGGATGAAACCACATCCGCAGCCAAGAGTTTTGCCCAATTTTT
TAACGGCGCTTTTGTGGATATTGATCCGAAAGAACCTGAGCAAACAGAAGCGGCTAAATCTAAATAA

Upstream 100 bases:

>100_bases
TTTCTGAGATCTTGCTTGAGAAGCATTAACAGTAGCACCATTCGGAAGCTCATCCACTAGAGTAGAGGTGGACGCCTTTG
CTAATTGATTAGGGTAAGCT

Downstream 100 bases:

>100_bases
CCGATGCTAATCCGTTTGGGGGACCCATACAGAGACGGAGCCAGCCTTACAGGCAAATTCAGCCCAACCCTCGGCATTGG
TCGTGATCGATTCAGAAATA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MAYEPLHHKYRPQVFADLVGQDAIATTLTNAIEFERIAPAYLFTGPRGTGKTSSARILAKSLNCLNSQTPTQTPCGTCSV
CQEVALGTSLDVIEIDAASNTGVDNIRDLIERAQFAPVQCRFKIYCLDEVHMLSTAAFNALLKTLEEPPDRVVFILATTD
PQRVLPTIISRCQRFDFRRIALDPMIQHLTHIAEQESIAITPTAVELIAQVAQGGLRDAESLLDQLSLLSGEIDNTQVWD
LVGSVPEQALLALLQAIIEQQPALMVERTHALLDRGREPLTVLQNLAGFYRDLLIAKTAPTRRDLVAITAPTWTDLCQLA
QQFEVDDILAKQQHLRNCETQIKNSTQPRLWLEVSLLGLLPGATQSTDPQPILIQITSQPLETATQAPEPVSAGPAHPVP
PSKASAPTQPSPVVDTPQPAPQGSFQAPPVPEPQVIPQPEAHSPEAEDLPNPLEDLPEPLEDLPTPLEETPDPLPSLQTD
SIPHPALPQPEPTPAPLPPPSAPPAPVQVDLTEVWQQLLQSLNLPSRALLKEHGQLLYWQGREVRIGIRKTLLRLAQGKV
QELEETFEKCFNRKVKVTLKVLTEEQMRAKPASPSTSSAPPSVSAPSPVSAPPPNIAAPQPIATPPAPIQNGHAAPQTAP
QKPSEAPPTWQSEDETTSAAKSFAQFFNGAFVDIDPKEPEQTEAAKSK

Sequences:

>Translated_688_residues
MAYEPLHHKYRPQVFADLVGQDAIATTLTNAIEFERIAPAYLFTGPRGTGKTSSARILAKSLNCLNSQTPTQTPCGTCSV
CQEVALGTSLDVIEIDAASNTGVDNIRDLIERAQFAPVQCRFKIYCLDEVHMLSTAAFNALLKTLEEPPDRVVFILATTD
PQRVLPTIISRCQRFDFRRIALDPMIQHLTHIAEQESIAITPTAVELIAQVAQGGLRDAESLLDQLSLLSGEIDNTQVWD
LVGSVPEQALLALLQAIIEQQPALMVERTHALLDRGREPLTVLQNLAGFYRDLLIAKTAPTRRDLVAITAPTWTDLCQLA
QQFEVDDILAKQQHLRNCETQIKNSTQPRLWLEVSLLGLLPGATQSTDPQPILIQITSQPLETATQAPEPVSAGPAHPVP
PSKASAPTQPSPVVDTPQPAPQGSFQAPPVPEPQVIPQPEAHSPEAEDLPNPLEDLPEPLEDLPTPLEETPDPLPSLQTD
SIPHPALPQPEPTPAPLPPPSAPPAPVQVDLTEVWQQLLQSLNLPSRALLKEHGQLLYWQGREVRIGIRKTLLRLAQGKV
QELEETFEKCFNRKVKVTLKVLTEEQMRAKPASPSTSSAPPSVSAPSPVSAPPPNIAAPQPIATPPAPIQNGHAAPQTAP
QKPSEAPPTWQSEDETTSAAKSFAQFFNGAFVDIDPKEPEQTEAAKSK
>Mature_687_residues
AYEPLHHKYRPQVFADLVGQDAIATTLTNAIEFERIAPAYLFTGPRGTGKTSSARILAKSLNCLNSQTPTQTPCGTCSVC
QEVALGTSLDVIEIDAASNTGVDNIRDLIERAQFAPVQCRFKIYCLDEVHMLSTAAFNALLKTLEEPPDRVVFILATTDP
QRVLPTIISRCQRFDFRRIALDPMIQHLTHIAEQESIAITPTAVELIAQVAQGGLRDAESLLDQLSLLSGEIDNTQVWDL
VGSVPEQALLALLQAIIEQQPALMVERTHALLDRGREPLTVLQNLAGFYRDLLIAKTAPTRRDLVAITAPTWTDLCQLAQ
QFEVDDILAKQQHLRNCETQIKNSTQPRLWLEVSLLGLLPGATQSTDPQPILIQITSQPLETATQAPEPVSAGPAHPVPP
SKASAPTQPSPVVDTPQPAPQGSFQAPPVPEPQVIPQPEAHSPEAEDLPNPLEDLPEPLEDLPTPLEETPDPLPSLQTDS
IPHPALPQPEPTPAPLPPPSAPPAPVQVDLTEVWQQLLQSLNLPSRALLKEHGQLLYWQGREVRIGIRKTLLRLAQGKVQ
ELEETFEKCFNRKVKVTLKVLTEEQMRAKPASPSTSSAPPSVSAPSPVSAPPPNIAAPQPIATPPAPIQNGHAAPQTAPQ
KPSEAPPTWQSEDETTSAAKSFAQFFNGAFVDIDPKEPEQTEAAKSK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:
GO:0000166: DNA polymerase III gamma and tau subunits
GO:0003677: DNA polymerase III gamma and tau subunits
GO:0003887: DNA polymerase III gamma and tau subunits
GO:0005524: DNA polymerase III gamma and tau subunits
GO:0006260: DNA polymerase III gamma and tau subunits
GO:0009360: DNA polymerase III gamma and tau subunits
GO:0017111: DNA polymerase III gamma and tau subunits

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=263, Percent_Identity=26.9961977186312, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI31881687, Length=263, Percent_Identity=26.9961977186312, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI6677723, Length=239, Percent_Identity=28.0334728033473, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI194306571, Length=239, Percent_Identity=28.0334728033473, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI194306567, Length=239, Percent_Identity=28.0334728033473, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI31563534, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=315, Percent_Identity=44.4444444444444, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71986063, Length=250, Percent_Identity=27.6, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=248, Percent_Identity=27.0161290322581, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=274, Percent_Identity=27.007299270073, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=313, Percent_Identity=24.9201277955272, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324039, Length=264, Percent_Identity=25, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324478, Length=255, Percent_Identity=25.8823529411765, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=264, Percent_Identity=28.030303030303, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921076, Length=256, Percent_Identity=27.734375, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647857, Length=292, Percent_Identity=25.6849315068493, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 74751; Mature: 74619

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEPLHHKYRPQVFADLVGQDAIATTLTNAIEFERIAPAYLFTGPRGTGKTSSARILAK
CCCCCCCHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
SLNCLNSQTPTQTPCGTCSVCQEVALGTSLDVIEIDAASNTGVDNIRDLIERAQFAPVQC
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEE
RFKIYCLDEVHMLSTAAFNALLKTLEEPPDRVVFILATTDPQRVLPTIISRCQRFDFRRI
EEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHH
ALDPMIQHLTHIAEQESIAITPTAVELIAQVAQGGLRDAESLLDQLSLLSGEIDNTQVWD
HHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHH
LVGSVPEQALLALLQAIIEQQPALMVERTHALLDRGREPLTVLQNLAGFYRDLLIAKTAP
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
TRRDLVAITAPTWTDLCQLAQQFEVDDILAKQQHLRNCETQIKNSTQPRLWLEVSLLGLL
CCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHC
PGATQSTDPQPILIQITSQPLETATQAPEPVSAGPAHPVPPSKASAPTQPSPVVDTPQPA
CCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQGSFQAPPVPEPQVIPQPEAHSPEAEDLPNPLEDLPEPLEDLPTPLEETPDPLPSLQTD
CCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
SIPHPALPQPEPTPAPLPPPSAPPAPVQVDLTEVWQQLLQSLNLPSRALLKEHGQLLYWQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCHHHHHHHCCCEEEEC
GREVRIGIRKTLLRLAQGKVQELEETFEKCFNRKVKVTLKVLTEEQMRAKPASPSTSSAP
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCCC
PSVSAPSPVSAPPPNIAAPQPIATPPAPIQNGHAAPQTAPQKPSEAPPTWQSEDETTSAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KSFAQFFNGAFVDIDPKEPEQTEAAKSK
HHHHHHHCCCEEECCCCCCCHHHHHCCC
>Mature Secondary Structure 
AYEPLHHKYRPQVFADLVGQDAIATTLTNAIEFERIAPAYLFTGPRGTGKTSSARILAK
CCCCCCHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
SLNCLNSQTPTQTPCGTCSVCQEVALGTSLDVIEIDAASNTGVDNIRDLIERAQFAPVQC
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEE
RFKIYCLDEVHMLSTAAFNALLKTLEEPPDRVVFILATTDPQRVLPTIISRCQRFDFRRI
EEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHH
ALDPMIQHLTHIAEQESIAITPTAVELIAQVAQGGLRDAESLLDQLSLLSGEIDNTQVWD
HHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHH
LVGSVPEQALLALLQAIIEQQPALMVERTHALLDRGREPLTVLQNLAGFYRDLLIAKTAP
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
TRRDLVAITAPTWTDLCQLAQQFEVDDILAKQQHLRNCETQIKNSTQPRLWLEVSLLGLL
CCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHC
PGATQSTDPQPILIQITSQPLETATQAPEPVSAGPAHPVPPSKASAPTQPSPVVDTPQPA
CCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQGSFQAPPVPEPQVIPQPEAHSPEAEDLPNPLEDLPEPLEDLPTPLEETPDPLPSLQTD
CCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
SIPHPALPQPEPTPAPLPPPSAPPAPVQVDLTEVWQQLLQSLNLPSRALLKEHGQLLYWQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCHHHHHHHCCCEEEEC
GREVRIGIRKTLLRLAQGKVQELEETFEKCFNRKVKVTLKVLTEEQMRAKPASPSTSSAP
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCCCC
PSVSAPSPVSAPPPNIAAPQPIATPPAPIQNGHAAPQTAPQKPSEAPPTWQSEDETTSAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KSFAQFFNGAFVDIDPKEPEQTEAAKSK
HHHHHHHCCCEEECCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]