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The map label for this gene is nuoM [H]

Identifier: 158335283

GI number: 158335283

Start: 2117511

End: 2118983

Strand: Reverse

Name: nuoM [H]

Synonym: AM1_2126

Alternate gene names: 158335283

Gene position: 2118983-2117511 (Counterclockwise)

Preceding gene: 158335284

Following gene: 158335281

Centisome position: 32.58

GC content: 48.88

Gene sequence:

>1473_bases
ATGGCATCTCATCTTTTATCCTTGATAATATTTTCCCCGCTCGTTGGGGCGGTCATAATCCTTTTGCTCCCTAAGGCTCA
AGAAAGCCTTTACAAATGGATATCTTTGGCCAATATGGTCGTGGTGAGTGCGCTTACATTTGCAGCATTCCTCCAATTTG
ACCCGAATCAGACTGGCTTTCAGCTGGTCGAAAAGACCCTCTGGATTCCTCAGCTCAATGTTTATTACTTGCTAGGAACT
GATGGGATTAGCTTCCCGATGGTGGTGTTGACCGCCTTGATTTCTACCCTGGCCAGTATTGGCTCTTTCAGCATCAAGAA
ACGGGAAAAAGAATACTACTGTCTCTACCTGTTTCTCGTCACAGGCATGATGGGCACCTTCTTGGCCCTAGACATGATTC
TGTTCTATGTCTTTTGGGAAGTCGTTCTCGTTCCCATGTATTTCTTGATTGGGATTTGGGGTGGCCCCAGGAAAGAGTAT
GCAGCGATGAAATTCTTCCTGTATACCTTTGCCGGTAGCTTGCTGATGTTGGTGGGCATTTTGGGGATGTACTTTAATTC
CGCTCCCCACACCTTCAATATTATGGAGCTAGTGGCCCAAGACTTTAGCTTTGGATTCCAAAAGATTGTCTTTTTGGCTC
TGTTTGTGGGCTTTGCAGTCAAAGTTCCCACCTTCCCCTTCCATACATGGCTACCCGATGCCCACGTGGAAGCCCCCACT
CCTATCAGCGTGATTCTGGCGGGTGTGTTGCTCAAAATGGGAACTTACGGATTTTTCCGCTTTAGCTTCCCGATTTTGCC
TGAAGCAGCGAACTGGTTCCGGCCTTATCTTGCTGTGTTAGCGGCCATTGGCATTGTCTATGGTGGGTTTATTGCCCTAG
CCCAGACAGACTTCAAAAAGATGGTGGCCTATTCTAGCATCAGTCACATGGGGTTCGTGTTGTTAGGCTTGGCAGCCTTC
TCCACCAATGGCTTTAACGGTGCCATGCTCCAGATGTTTAGCCATGGTGTAATCACTGGAGCCTTGTTCTTACTGGTGGG
CGTCATTTACGACCGGGCTCATACCCGCGATATGAACGCCTTTGGTGGTCTGAATGCTCAACTTCCAGTTTACTCAGGAT
TTTTGGTATTCTTCTCCCTTGCCTCTTTGGGGCTACCGGGCCTCAGCGGCTTTGTCAGTGAGTTTCTGGTCTTACTGGGG
TCCTATGAATACAGCAAGCTCTATACCGCGTTTGCCTGTATGGGCATTCTCTTAGCGGCCTGTTATCTCCTGTTTATGGT
GCGCCGGGTACTGTTGGGACCTGCCAACCCCAAGTGGGAAAGCTTGCCCGATATCAATATGCGTGAGGTGGTCACAGTTG
TTCCGCTCCTGATTATCACCCTAGGAATCGGAATTTATCCTCGCTATCTCCTTAGCTTCTTTATTCCGACACTGCAGGAT
CTGCTCGCTAGCATTGGCGGCACCCTGATGTAG

Upstream 100 bases:

>100_bases
CAATTTTATTTACTGATTACTTGCGTTAGCGTTCTGGCCTTCCTGTCGGTTGAATTAACCTCAGGTTTCCAAGAACTTCC
TTTGCTCAGAGAGGAGTTGT

Downstream 100 bases:

>100_bases
TCTTTTCACTCCTCGCATTAACTCCTCACTCAAAGCCCCCTAGAACGATAGTTCTAGGGGGTTCGATTATGGTCTAGGTT
GTCAATAGTGCTATGAACCC

Product: proton-translocating NAD(P)H-quinone oxidoreductase, chain M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MASHLLSLIIFSPLVGAVIILLLPKAQESLYKWISLANMVVVSALTFAAFLQFDPNQTGFQLVEKTLWIPQLNVYYLLGT
DGISFPMVVLTALISTLASIGSFSIKKREKEYYCLYLFLVTGMMGTFLALDMILFYVFWEVVLVPMYFLIGIWGGPRKEY
AAMKFFLYTFAGSLLMLVGILGMYFNSAPHTFNIMELVAQDFSFGFQKIVFLALFVGFAVKVPTFPFHTWLPDAHVEAPT
PISVILAGVLLKMGTYGFFRFSFPILPEAANWFRPYLAVLAAIGIVYGGFIALAQTDFKKMVAYSSISHMGFVLLGLAAF
STNGFNGAMLQMFSHGVITGALFLLVGVIYDRAHTRDMNAFGGLNAQLPVYSGFLVFFSLASLGLPGLSGFVSEFLVLLG
SYEYSKLYTAFACMGILLAACYLLFMVRRVLLGPANPKWESLPDINMREVVTVVPLLIITLGIGIYPRYLLSFFIPTLQD
LLASIGGTLM

Sequences:

>Translated_490_residues
MASHLLSLIIFSPLVGAVIILLLPKAQESLYKWISLANMVVVSALTFAAFLQFDPNQTGFQLVEKTLWIPQLNVYYLLGT
DGISFPMVVLTALISTLASIGSFSIKKREKEYYCLYLFLVTGMMGTFLALDMILFYVFWEVVLVPMYFLIGIWGGPRKEY
AAMKFFLYTFAGSLLMLVGILGMYFNSAPHTFNIMELVAQDFSFGFQKIVFLALFVGFAVKVPTFPFHTWLPDAHVEAPT
PISVILAGVLLKMGTYGFFRFSFPILPEAANWFRPYLAVLAAIGIVYGGFIALAQTDFKKMVAYSSISHMGFVLLGLAAF
STNGFNGAMLQMFSHGVITGALFLLVGVIYDRAHTRDMNAFGGLNAQLPVYSGFLVFFSLASLGLPGLSGFVSEFLVLLG
SYEYSKLYTAFACMGILLAACYLLFMVRRVLLGPANPKWESLPDINMREVVTVVPLLIITLGIGIYPRYLLSFFIPTLQD
LLASIGGTLM
>Mature_489_residues
ASHLLSLIIFSPLVGAVIILLLPKAQESLYKWISLANMVVVSALTFAAFLQFDPNQTGFQLVEKTLWIPQLNVYYLLGTD
GISFPMVVLTALISTLASIGSFSIKKREKEYYCLYLFLVTGMMGTFLALDMILFYVFWEVVLVPMYFLIGIWGGPRKEYA
AMKFFLYTFAGSLLMLVGILGMYFNSAPHTFNIMELVAQDFSFGFQKIVFLALFVGFAVKVPTFPFHTWLPDAHVEAPTP
ISVILAGVLLKMGTYGFFRFSFPILPEAANWFRPYLAVLAAIGIVYGGFIALAQTDFKKMVAYSSISHMGFVLLGLAAFS
TNGFNGAMLQMFSHGVITGALFLLVGVIYDRAHTRDMNAFGGLNAQLPVYSGFLVFFSLASLGLPGLSGFVSEFLVLLGS
YEYSKLYTAFACMGILLAACYLLFMVRRVLLGPANPKWESLPDINMREVVTVVPLLIITLGIGIYPRYLLSFFIPTLQDL
LASIGGTLM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=324, Percent_Identity=35.1851851851852, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI251831117, Length=347, Percent_Identity=25.9365994236311, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788613, Length=486, Percent_Identity=38.8888888888889, Blast_Score=326, Evalue=3e-90,
Organism=Escherichia coli, GI1788827, Length=288, Percent_Identity=28.8194444444444, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788614, Length=502, Percent_Identity=26.4940239043825, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788831, Length=298, Percent_Identity=29.1946308724832, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788829, Length=403, Percent_Identity=25.3101736972705, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI145693160, Length=309, Percent_Identity=28.1553398058252, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI2367154, Length=237, Percent_Identity=25.3164556962025, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54203; Mature: 54071

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCC
>Mature Secondary Structure 
ASHLLSLIIFSPLVGAVIILLLPKAQESLYKWISLANMVVVSALTFAAFLQFDPNQTGF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH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HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]