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The map label for this gene is msrB

Identifier: 158335272

GI number: 158335272

Start: 2105169

End: 2105564

Strand: Direct

Name: msrB

Synonym: AM1_2115

Alternate gene names: 158335272

Gene position: 2105169-2105564 (Clockwise)

Preceding gene: 158335267

Following gene: 158335273

Centisome position: 32.37

GC content: 49.49

Gene sequence:

>396_bases
ATGGAAAAAGTACAGAAAACGGAGCAGGAATGGGAAGCCCAACTCACTCCAGAACAGTTCCGTGTGACCCGTCACCATGG
AACGGAGCGGGCCTTTACCGGGGAATACCATGACCTCAAGGCAGCAGGCACCTACCAATGTGTGTGTTGCGGTACCGAAT
TATTCACATCCGATACCAAATTTGATTCTGGGACGGGCTGGCCTAGCTTTTGGGCACCAGCGGATAAAACCCATGTCGAG
GAAAAGACGGATCGCAGTTTGTTTATGGTTCGAACTGAGGTACTCTGCGCTGTCTGCGATGCCCATCTTGGCCATGTTTT
TAATGATGGTCCAAAACCTACGGGCTTAAGATATTGCATGAACTCTGCTGCCCTCAAATTTGTCCCCAAAAGTTAA

Upstream 100 bases:

>100_bases
TAGAGAAGAGATATCAATAGTTCGCTCAATTGTGGCGGCTGTGAATGTTTCTCCTGATATCGCTTAAGCAATATTGCCCT
TCTGACTCAACACAAGATTT

Downstream 100 bases:

>100_bases
ACGTTGAGTCAATCATGGGGGTTAACCTCAGATTGGGCTATAGCCCAATCTCTGGAACTTATAGGCCCAACAGTGCTCAT
AGTCCTTTAAAGTCTCATCA

Product: methionine-R-sulfoxide reductase

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MEKVQKTEQEWEAQLTPEQFRVTRHHGTERAFTGEYHDLKAAGTYQCVCCGTELFTSDTKFDSGTGWPSFWAPADKTHVE
EKTDRSLFMVRTEVLCAVCDAHLGHVFNDGPKPTGLRYCMNSAALKFVPKS

Sequences:

>Translated_131_residues
MEKVQKTEQEWEAQLTPEQFRVTRHHGTERAFTGEYHDLKAAGTYQCVCCGTELFTSDTKFDSGTGWPSFWAPADKTHVE
EKTDRSLFMVRTEVLCAVCDAHLGHVFNDGPKPTGLRYCMNSAALKFVPKS
>Mature_131_residues
MEKVQKTEQEWEAQLTPEQFRVTRHHGTERAFTGEYHDLKAAGTYQCVCCGTELFTSDTKFDSGTGWPSFWAPADKTHVE
EKTDRSLFMVRTEVLCAVCDAHLGHVFNDGPKPTGLRYCMNSAALKFVPKS

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:
GO:0008113: Methionine-R-sulfoxide reductase, putative
GO:0016491: Methionine-R-sulfoxide reductase, putative
GO:0055114: Methionine-R-sulfoxide reductase, putative

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=127, Percent_Identity=54.3307086614173, Blast_Score=142, Evalue=7e-35,
Organism=Homo sapiens, GI301336162, Length=127, Percent_Identity=54.3307086614173, Blast_Score=142, Evalue=7e-35,
Organism=Homo sapiens, GI73089054, Length=127, Percent_Identity=54.3307086614173, Blast_Score=142, Evalue=7e-35,
Organism=Homo sapiens, GI37620216, Length=127, Percent_Identity=54.3307086614173, Blast_Score=142, Evalue=7e-35,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=53.0769230769231, Blast_Score=141, Evalue=2e-34,
Organism=Homo sapiens, GI7706511, Length=104, Percent_Identity=38.4615384615385, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788077, Length=123, Percent_Identity=49.5934959349593, Blast_Score=130, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17553450, Length=125, Percent_Identity=50.4, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI115532676, Length=125, Percent_Identity=50.4, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319816, Length=129, Percent_Identity=37.984496124031, Blast_Score=94, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24645799, Length=128, Percent_Identity=52.34375, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45553335, Length=128, Percent_Identity=52.34375, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356369, Length=128, Percent_Identity=52.34375, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24645801, Length=139, Percent_Identity=48.2014388489209, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221378664, Length=128, Percent_Identity=50.78125, Blast_Score=133, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645804, Length=139, Percent_Identity=48.2014388489209, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221378662, Length=135, Percent_Identity=48.1481481481481, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_ACAM1 (B0BYW4)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516444.1
- ProteinModelPortal:   B0BYW4
- SMR:   B0BYW4
- GeneID:   5680929
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2115
- HOGENOM:   HBG715255
- OMA:   CINSICL
- BioCyc:   AMAR329726:AM1_2115-MONOMER
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 14807; Mature: 14807

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVQKTEQEWEAQLTPEQFRVTRHHGTERAFTGEYHDLKAAGTYQCVCCGTELFTSDTK
CCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCC
FDSGTGWPSFWAPADKTHVEEKTDRSLFMVRTEVLCAVCDAHLGHVFNDGPKPTGLRYCM
CCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
NSAALKFVPKS
CCHHEEEECCC
>Mature Secondary Structure
MEKVQKTEQEWEAQLTPEQFRVTRHHGTERAFTGEYHDLKAAGTYQCVCCGTELFTSDTK
CCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCC
FDSGTGWPSFWAPADKTHVEEKTDRSLFMVRTEVLCAVCDAHLGHVFNDGPKPTGLRYCM
CCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
NSAALKFVPKS
CCHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA