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The map label for this gene is fur [H]

Identifier: 158335267

GI number: 158335267

Start: 2098221

End: 2098670

Strand: Direct

Name: fur [H]

Synonym: AM1_2111

Alternate gene names: 158335267

Gene position: 2098221-2098670 (Clockwise)

Preceding gene: 158335266

Following gene: 158335272

Centisome position: 32.26

GC content: 41.78

Gene sequence:

>450_bases
ATGTACAGTGCTAACTCACTTAAAGCAGAACTCAACGATCGAGGGTGGCGTCTTACACCTCAACGAGAAACAATCCTCAA
TGTGTTTCAAAACCTGCAAAAAGGGAAGCATTTAAGCGCTGAAGATTTATACAATCTCTTGGAAGAACAGGGTGAGCCTA
TTAGTTTATCCACGATTTATAGAACGGTAAAATTAATGGCTCGCATGGGGATTTTGCGAGAGTTAGAATTCGCTGAAGGT
CATAAACACTATGAACTAAATCAGCCCTATCCCTACCATCATCACCACCTGATTTGCGTTAAATGCAACAAAACCATTGA
GTTTAAAAGTGACTCTGTTTTGAAGATTGGCTCAAAGACAGCGAAAAAGTCAGGCTTCCATTTATTGGACTGTCAACTGT
CGATTCATGCCATTTGCCCTCAATGCCAGCGGTCTTTACTGCCCACCTGA

Upstream 100 bases:

>100_bases
TCCAAGCCCTCGCTTTACTTTTCTCAATAGAATCTTCTTGTTGCCAAAGGATCCATCATTCGTTAGACTTTCAATAAGCT
CATGTTCTTGAGAAAAGACT

Downstream 100 bases:

>100_bases
TCCAGGGTGTGACAATGTTGAATCATGTCTGGGAAAAATTGCGCAAAGTCCTGGGCAACAGTGGGGTAGTGGGTCAACCA
ATCTTCAATAGCAGGGCATA

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MYSANSLKAELNDRGWRLTPQRETILNVFQNLQKGKHLSAEDLYNLLEEQGEPISLSTIYRTVKLMARMGILRELEFAEG
HKHYELNQPYPYHHHHLICVKCNKTIEFKSDSVLKIGSKTAKKSGFHLLDCQLSIHAICPQCQRSLLPT

Sequences:

>Translated_149_residues
MYSANSLKAELNDRGWRLTPQRETILNVFQNLQKGKHLSAEDLYNLLEEQGEPISLSTIYRTVKLMARMGILRELEFAEG
HKHYELNQPYPYHHHHLICVKCNKTIEFKSDSVLKIGSKTAKKSGFHLLDCQLSIHAICPQCQRSLLPT
>Mature_149_residues
MYSANSLKAELNDRGWRLTPQRETILNVFQNLQKGKHLSAEDLYNLLEEQGEPISLSTIYRTVKLMARMGILRELEFAEG
HKHYELNQPYPYHHHHLICVKCNKTIEFKSDSVLKIGSKTAKKSGFHLLDCQLSIHAICPQCQRSLLPT

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates genes involved in iron scavenging or photosynthetic electron transport [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=131, Percent_Identity=37.4045801526718, Blast_Score=80, Evalue=4e-17,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 17188; Mature: 17188

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSANSLKAELNDRGWRLTPQRETILNVFQNLQKGKHLSAEDLYNLLEEQGEPISLSTIY
CCCCCCCCEEECCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHH
RTVKLMARMGILRELEFAEGHKHYELNQPYPYHHHHLICVKCNKTIEFKSDSVLKIGSKT
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEEECCEEEECCCCEEECCCCH
AKKSGFHLLDCQLSIHAICPQCQRSLLPT
HHCCCCEEEEEEHHHHHHCHHHHHHCCCC
>Mature Secondary Structure
MYSANSLKAELNDRGWRLTPQRETILNVFQNLQKGKHLSAEDLYNLLEEQGEPISLSTIY
CCCCCCCCEEECCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHH
RTVKLMARMGILRELEFAEGHKHYELNQPYPYHHHHLICVKCNKTIEFKSDSVLKIGSKT
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEEECCEEEECCCCEEECCCCH
AKKSGFHLLDCQLSIHAICPQCQRSLLPT
HHCCCCEEEEEEHHHHHHCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8704986 [H]