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The map label for this gene is gauB [C]

Identifier: 158335029

GI number: 158335029

Start: 1851960

End: 1853123

Strand: Direct

Name: gauB [C]

Synonym: AM1_1867

Alternate gene names: 158335029

Gene position: 1851960-1853123 (Clockwise)

Preceding gene: 158335028

Following gene: 158335030

Centisome position: 28.48

GC content: 51.12

Gene sequence:

>1164_bases
GTGGATATTCAAATTGGCCGTGGCAAAACGGCGCGTAGAGCATATGGAATTGACGAAATTGCCCTTTCACCAGGACAACG
AACCCTAGATCCACAATTGGCAGATACCCAATGGCAAATTGGTGGTATTCAGCGGGAGATTCCCATTCTAGCGAGTGCAA
TGGATGGGGTTGTGGATGTCAAAATGGCCGTTCGTCTATCAGAATTAGGCGCCCTAGGGGTATTGAATTTGGAAGGGATT
CAAACCCGATACAGCGATCCAGAGCCCATTCTGGACAAAATCGCCGGGGTTGATGTGAATGGCTTTGTGCCACTCATGCA
AGAACTCTACGCAGAACCCATCAAACCGGAACTGATTCGCGAGCGCATCACCCAGATCAAGTCTCAAGGAGGCATTGCAG
CGGTGAGTGCAACACCGATCGGGGCTAGTAAATTTGGGCAAGCTGTGGTTGACGCAGGTGCGGATTTATTTTTTATCCAG
GCAACAGTCGTTTCCACGGATCACGTGTCTCCAGAAAGTGTTACCCCTCTTGATCTAGCTAAGTTTTGCCAAGACCTCCC
GATCCCTGTGGTGATGGGAAATTGTGTAACCTATGAAGTTACAAAAAGCTTAATGCAGGCCGGTGCTGCAGCAGTCTTGG
TGGGTATTGGTCCCGGTGCAGCTTGCACAACCCGAGGCGTTTTGGGAGTTGGGGTTCCGCAAGCAACTGCGATCTCAGAC
TGTGCTGCCGCTCGTGATGACCATTTTCGCGAGACTAACCAATATATTCCGATCATTGCGGATGGGGGCCTGATTACTGG
CGGTGATGTGTGCAAATGTATCGCCTGTGGTGCCGACGCAATTATGATGGGCTCGCCCATTGCTAGAGCAGCGGAAGCAC
CAGGACGAGGATTTCACTGGGGAATGGCAACGCCTAGTCCTGTGTTGCCCCGAGGGACACGAATTCGGGTCGGGACAACC
GGTACCCTAGAGCAAATTCTGCGAGGACCAGCTCAGTTAGATGATGGCACCCACAACTTTCTTGGATCCTTGCAAACGAG
CATGGGGACTTTAGGGGCCAAAGATATTAAACAGATGCAGCAAGTAGAGGTAGTGGTTGCTCCATCTCTGCTGACAGAAG
GGAAAGTCTACCAAGCAGCCCAAAAACTAGGCATGGGTAAATAA

Upstream 100 bases:

>100_bases
GCGATATGCCACACCTGCTAATATTCAAGTCTTTGTAAGACTTTGACAGGGCAATTTGGCTTTGTTAGTCTAGCTAAATC
GTTCTGGAATGGTTACTGGT

Downstream 100 bases:

>100_bases
CAAAAATTTGCCAAACTTTACACGTATAGATGCCGATCTTTGCCAAAAAAGGTATGGCAAACGTGAATTGGTTGCCTAGA
ATGGGTATAGCGGAGACGCA

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDIQIGRGKTARRAYGIDEIALSPGQRTLDPQLADTQWQIGGIQREIPILASAMDGVVDVKMAVRLSELGALGVLNLEGI
QTRYSDPEPILDKIAGVDVNGFVPLMQELYAEPIKPELIRERITQIKSQGGIAAVSATPIGASKFGQAVVDAGADLFFIQ
ATVVSTDHVSPESVTPLDLAKFCQDLPIPVVMGNCVTYEVTKSLMQAGAAAVLVGIGPGAACTTRGVLGVGVPQATAISD
CAAARDDHFRETNQYIPIIADGGLITGGDVCKCIACGADAIMMGSPIARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILRGPAQLDDGTHNFLGSLQTSMGTLGAKDIKQMQQVEVVVAPSLLTEGKVYQAAQKLGMGK

Sequences:

>Translated_387_residues
MDIQIGRGKTARRAYGIDEIALSPGQRTLDPQLADTQWQIGGIQREIPILASAMDGVVDVKMAVRLSELGALGVLNLEGI
QTRYSDPEPILDKIAGVDVNGFVPLMQELYAEPIKPELIRERITQIKSQGGIAAVSATPIGASKFGQAVVDAGADLFFIQ
ATVVSTDHVSPESVTPLDLAKFCQDLPIPVVMGNCVTYEVTKSLMQAGAAAVLVGIGPGAACTTRGVLGVGVPQATAISD
CAAARDDHFRETNQYIPIIADGGLITGGDVCKCIACGADAIMMGSPIARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILRGPAQLDDGTHNFLGSLQTSMGTLGAKDIKQMQQVEVVVAPSLLTEGKVYQAAQKLGMGK
>Mature_387_residues
MDIQIGRGKTARRAYGIDEIALSPGQRTLDPQLADTQWQIGGIQREIPILASAMDGVVDVKMAVRLSELGALGVLNLEGI
QTRYSDPEPILDKIAGVDVNGFVPLMQELYAEPIKPELIRERITQIKSQGGIAAVSATPIGASKFGQAVVDAGADLFFIQ
ATVVSTDHVSPESVTPLDLAKFCQDLPIPVVMGNCVTYEVTKSLMQAGAAAVLVGIGPGAACTTRGVLGVGVPQATAISD
CAAARDDHFRETNQYIPIIADGGLITGGDVCKCIACGADAIMMGSPIARAAEAPGRGFHWGMATPSPVLPRGTRIRVGTT
GTLEQILRGPAQLDDGTHNFLGSLQTSMGTLGAKDIKQMQQVEVVVAPSLLTEGKVYQAAQKLGMGK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=223, Percent_Identity=30.0448430493274, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035150, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI217035146, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI217035148, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI34328930, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI34328928, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI156616279, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI217035152, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI50541954, Length=200, Percent_Identity=30, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI50541952, Length=200, Percent_Identity=30, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI50541948, Length=200, Percent_Identity=30, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI50541956, Length=184, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI156104880, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786293, Length=185, Percent_Identity=33.5135135135135, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788855, Length=240, Percent_Identity=32.0833333333333, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994385, Length=239, Percent_Identity=32.6359832635983, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994389, Length=239, Percent_Identity=32.6359832635983, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560440, Length=184, Percent_Identity=30.9782608695652, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322012, Length=155, Percent_Identity=34.1935483870968, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323464, Length=155, Percent_Identity=33.5483870967742, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323585, Length=155, Percent_Identity=33.5483870967742, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571163, Length=197, Percent_Identity=31.9796954314721, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24641071, Length=197, Percent_Identity=31.9796954314721, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24641073, Length=197, Percent_Identity=31.9796954314721, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40481; Mature: 40481

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQIGRGKTARRAYGIDEIALSPGQRTLDPQLADTQWQIGGIQREIPILASAMDGVVDV
CCCCCCCCCCHHHHCCCHHHEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHH
KMAVRLSELGALGVLNLEGIQTRYSDPEPILDKIAGVDVNGFVPLMQELYAEPIKPELIR
HHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHH
ERITQIKSQGGIAAVSATPIGASKFGQAVVDAGADLFFIQATVVSTDHVSPESVTPLDLA
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHH
KFCQDLPIPVVMGNCVTYEVTKSLMQAGAAAVLVGIGPGAACTTRGVLGVGVPQATAISD
HHHHHCCCCEEECCEEHHHHHHHHHHCCCEEEEEECCCCCHHHHCCEEECCCCCHHHHHH
CAAARDDHFRETNQYIPIIADGGLITGGDVCKCIACGADAIMMGSPIARAAEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHCCCCCEECCCCHHHHHCCCCCCEEC
GMATPSPVLPRGTRIRVGTTGTLEQILRGPAQLDDGTHNFLGSLQTSMGTLGAKDIKQMQ
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QVEVVVAPSLLTEGKVYQAAQKLGMGK
HHHEEEECHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MDIQIGRGKTARRAYGIDEIALSPGQRTLDPQLADTQWQIGGIQREIPILASAMDGVVDV
CCCCCCCCCCHHHHCCCHHHEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHH
KMAVRLSELGALGVLNLEGIQTRYSDPEPILDKIAGVDVNGFVPLMQELYAEPIKPELIR
HHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHH
ERITQIKSQGGIAAVSATPIGASKFGQAVVDAGADLFFIQATVVSTDHVSPESVTPLDLA
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHH
KFCQDLPIPVVMGNCVTYEVTKSLMQAGAAAVLVGIGPGAACTTRGVLGVGVPQATAISD
HHHHHCCCCEEECCEEHHHHHHHHHHCCCEEEEEECCCCCHHHHCCEEECCCCCHHHHHH
CAAARDDHFRETNQYIPIIADGGLITGGDVCKCIACGADAIMMGSPIARAAEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECCHHHHHHHCCCCCEECCCCHHHHHCCCCCCEEC
GMATPSPVLPRGTRIRVGTTGTLEQILRGPAQLDDGTHNFLGSLQTSMGTLGAKDIKQMQ
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QVEVVVAPSLLTEGKVYQAAQKLGMGK
HHHEEEECHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA